Spectrophotometric Determination and Cloud Point Extraction of Lamotrigine Drug in Pure Form and Pharmaceutical Preparation

Abstract

A new, simple and sensitive of two spectrophotometric methods for the determination of Lamotrigine drug has been developed. First method is based on diazotization of O-aminobenzoic acid, by sodium nitrite in acidic medium at 5Cº followed by coupling with Lamotrigine in alkaline media to yield orange coloured products with absorption maxima at 424 nm. Beer's law is obeyed from 0.5-18 µg mL -1 with r=0.9997 Sandell's sensitivity were 0.0888 μg•cm -2 , molar absorptivity

Spectrophotometric Determination of Methyl Paraben in Pharmaceutical Formulations by Oxidative Coupling Reaction

“…the volume is completed to(25 ml) in a volumetric flasks with distilled water, the value of the absorption of the colored product remain for not less than (50) min. The results are show on Table (7). The result shown in table (8) indicate that the water is a good medium for reaction and give good absorption value at the wavelength of 600 nm, it used as the best solvent in the subsequent experiments.…”

“…Instance paraben is now used as a preservative in food, pharmaceuticals and cosmetics [5] ,dayily used the productes that continue of methyl paraben may be caused in the future breast cancer [6] . Different analytical method have been used for the determination of MP such as Spectrophotometric method [7] , HPLC [8] , electrochemical method [9] , flowinjection technique [10] , and Detection chemical fluorescence [11] .…”