Spectrophotometric and spectrofluorimetric methods for analysis of tramadol, acebutolol and dothiepin in pharmaceutical preparations

Abdellatef, Hisham E.; Elhenawee, Magda; El‐Sayed, Heba M.; Ayad, Magda M.

doi:10.1016/j.saa.2006.02.008

Cited by 59 publications

(32 citation statements)

References 21 publications

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“…A number of assays have been reported for detection of TR in biological and pharmaceutical samples, including chromatographic [5][6][7][8][9][10][11] , mass spectrometric [11][12][13] , spectrophotometric [14][15][16] ,and Capillary electrophoresis 17 . However, chromatography requires the use of organic solvents, expensive instruments, and time-consuming operating steps [5][6][7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Investigated the Supramolecular Interaction of Tramadol Hydrochloride With P-Sulfonated Calix[4,6,8]arene

Zhao

Chen

Pang

et al. 2015

J. Chil. Chem. Soc.

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In this paper, the interaction behavior of p-sulfonated calix[n]arene (SCnA) with tramadol hydrochloride was investigated by fluorescence spectra, 1 H NMR spectra, and theoretical calculations in aqueous solution. At the optimized conditions, the fluorescence intensity of tramadol hydrochloride showed positive correlation to the concentration of SCnA, which led to a validated, simple, and sensitive fluorescence quenching method for the determination of tramadol hydrochloride was established for the first time. Moreover, the interaction based on SCnA superstructure provided has promising potential for therapeutic monitoring and pharmacokinetics and clinical application

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Section: Introductionmentioning

confidence: 99%

Investigated the Supramolecular Interaction of Tramadol Hydrochloride With P-Sulfonated Calix[4,6,8]arene

Zhao

Chen

Pang

et al. 2015

J. Chil. Chem. Soc.

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“…The developed method is more economical as compared to sophisticated International Letters of Natural Sciences Vol. 16chromatographic techniques which make it suitable for routine quality control analysis of TDL.…”

Section: Resultsmentioning

confidence: 99%

“…The results showed that 1.5 mL of International Letters of Natural Sciences Vol. 16MBTH was sufficient to give maximum intensity of the color. Therefore, 1.5 mL of 0.2 % MBTH was chosen for the quantification of TDL by the method A.…”

Section: 6 Effect Of 3-methyl-2-benzothizaolinone Hydrazonementioning

confidence: 99%

“…The literature survey reveals spectrofluorimetry [16], HPLC with DAD detection [17], HPLC with UV detection [18][19][20], HPLC with fluorescence detection [21][22][23][24], LC/PDA-ESI-MS/MS [24], potentiometry [25,26], square-wave voltammetric method with amperometric detection [27], gas chromatography with mass spectrophotometer [28,29], gas chromatography with nitrogen-phosphorus detection [30], HPTLC [31][32][33] have been employed for the quantification of TDL in pharmaceutical preparations and biological fluids.…”

Section: Introductionmentioning

confidence: 99%

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Enzymatic Assay of Opioid Analgesic, Tramadol, Using Horseradish Peroxidase

N¹,

Srilakshmi

Alekya³

et al. 2014

ILNS

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Three novel and sensitive enzymatic methods have been developed for the quantification of tramadol in pharmaceutical dosage forms. The proposed methods are based on the reaction of tramadol with 3-methylbenzothiazoline-2-one hydrazone (method A), aniline (method B) and aminoantipyrine in the presence of hydrogen peroxide and horseradish peroxidase to give colored complexes. The colored complexes obtained with 3-methylbenzothiazoline-2-one hydrazone, aniline and aminoantipyrine exhibit absorption maxima at 480 nm, 550 nm and 530 nm, respectively. Regression analysis of Beer's plots showed good correlation for tramadol in the concentration range (μg/mL) 2-12 for the methods A & B and 4-24 for the method C. The experimental parameters were studied and optimized. The precision and accuracy of the methods were satisfactory. The proposed methods were successfully applied for the quantification of tramadol in 3 brands of commercially available tablet dosage forms. The results were compared satisfactorily with the official method.

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“…Various methods have been reported for the determination of tramadol hydrochloride in biological fluids and in pharmaceutical preparations, including HPLC [6][7][8][9][10][11], HPTLC [12], GC [13,14], capillary electrophoresis(CE) [15,16], spectrophotometry [17][18][19], voltammetry [20] and potentiometry [21]. Each of the above methods had its own merits and disadvantages, for example , some of them were accurate and selective, but involved expensive instrumentation and were time consuming, needed preconcentration before determination because of lacking high sensitive detector; some were inherent simple but have low sensitivity .…”

Section: Introductionmentioning

confidence: 99%

Flow Injection Determination of Tramadol Based on Its Sensitizing Effect on the Chemiluminescent Reaction of Permanganate-Sulfite

Yao¹,

Zhang²,

Li³

2011

AJAC

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In this paper, a novel chemiluminescence (CL) method for the determination of tramadol has been developed by combining the flow injection technique and its sensitizing effect on the weak CL reaction between sulfite and acidic KMnO 4 . A mechanism for the CL reaction has been proposed on the basis of fluorescent and CL spectra. Under the optimized conditions, the proposed method allows the measurement of tramadol hydrochloride over the range of 0.04 -4 g/mLwith a correlation coefficient of 0.9995 (n = 8) and a detection limit of 0.01 g/mL (3σ), and the relative standard deviation for 2.0 g/mL tramadol (n = 11) is 2.1%. The utility of this method was demonstrated by determining tramadol hydrochloride in tablets and injections.

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Spectrophotometric and spectrofluorimetric methods for analysis of tramadol, acebutolol and dothiepin in pharmaceutical preparations

Cited by 59 publications

References 21 publications

Investigated the Supramolecular Interaction of Tramadol Hydrochloride With P-Sulfonated Calix[4,6,8]arene

Investigated the Supramolecular Interaction of Tramadol Hydrochloride With P-Sulfonated Calix[4,6,8]arene

Enzymatic Assay of Opioid Analgesic, Tramadol, Using Horseradish Peroxidase

Flow Injection Determination of Tramadol Based on Its Sensitizing Effect on the Chemiluminescent Reaction of Permanganate-Sulfite

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