Spectrophotometric and Principal Component Regression Chemometric Method for Simultaneous Determination of Hypertension Drug's in Commercial Pharmaceutical
Abstract:In this study, the simultaneous determination of Lisinopril (LIS) and Hydrochlorothiazide (HCT) in drug samples by chemometric approaches using UV spectrophotometry has been reported as a simple alternative to using separate models for each component. Spectra of LIS and HCT were recorded at several concentrations within their ranges and were used to compute the calibration mixture between wavelengths 200 and 350 nm at an interval of 5 nm was used for data acquisition. Principal component regression was used fo… Show more
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