Spectrophotometric and atomic absorption spectrometric determination of certain cephalosporins

Ayad, Magda M.; Shalaby, Abdalla; Abdellatef, Hisham E.; Elsaid, Heba M.

doi:10.1016/s0731-7085(98)00106-x

Cited by 47 publications

(17 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In these studies, the Table 6. It is seen from the table that all the solvents chosen for the study affect the color [22][23] formation. This is attributed to changes in the dielectric constant of the medium as well as non aqueous conditions.…”

Section: Effect Of Organic Solventsmentioning

confidence: 99%

Spectrophotometric Determination Studies of Cefotaxime (CFX) and their CFX- Cd (II) and CFX- Cu (II) Complexes

Kondaiah¹,

Chowdary²,

Reddy³

et al. 2017

Orient. J. Chem

View full text Add to dashboard Cite

In this work Cefotoxime (CFX) and its Cd (II) and Cu (II) metal complexes determination were carried out by spectrophotometric method. The following experimental procedures like effect of pH, effect of metal ion concentration, effect of drug concentration, effect of time, effect of organic solvents and the composition of the complex by mole ratio and job's continuous variation method and interference studies were carried out for the determination of metal ions and drug. In this research work, it is clear that Cd forms a stable 1:1 colored complex with CFX in basic medium and Cu forms stable 1:1 colored complex with CFX in acidic medium. Effect of pH was studied for CFX-Cd (II) and CFX-Cu (II) complexes; it is noticed from that at pH 11 CFX-Cd (II) and at pH 5.5 CFX-Cu (II) colored complexes were formed. In these reactions can be found the metal ions in the range 1.12 to 6.74 and 3.812 to 8.895 µg/ml and the drug in the range 0.02 to 0.14 mg/ml respectively for CFX-Cu (II) and CFX-Cu (II) complexes. Effect of time clearly suggest , that the maximum absorbance is obtained only after heating the mixture to 40 o & 60°C respectively for CFX-Cd (II) and CFX-Cu (II) complexes. It has been observed that the absorbance values remain constant thereafter; it indicates the formation of 1:1 stable metal complexes.

show abstract

Section: Effect Of Organic Solventsmentioning

confidence: 99%

Spectrophotometric Determination Studies of Cefotaxime (CFX) and their CFX- Cd (II) and CFX- Cu (II) Complexes

Kondaiah¹,

Chowdary²,

Reddy³

et al. 2017

Orient. J. Chem

View full text Add to dashboard Cite

show abstract

“…10 Cefazolin sodium has some analytical methods described in official compendia such as British, 11 European, 12 Japanese, 13 Portuguese 14 and US 15 pharmacopeias. In the literature, several methods have been described for the qualitative 16 and quantitative analysis of cefazolin sodium, included spectrophotometry, [17][18][19][20][21][22][23][24][25][26][27][28][29] high-performance liquid chromatography [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] and voltammetry. 48 However, most of them were time-consuming and dedicated to sophisticated and expensive analytical instruments.…”

Section: Introductionmentioning

confidence: 99%

New Environmentally Friendly Method for Quantification of Cefazolin Sodium

Rechelo¹,

Fernandes²,

Kogawa³

et al. 2017

ECB

View full text Add to dashboard Cite

Cefazolin sodium, a β-lactam antimicrobial agent belonging to the first generation cephalosporins, has a broad spectrum of action, acting against gram positive and gram negative bacteria. Stands out over other cephalosporins for its ability to also act against some species of Enterobacter, and have a long half-life, thus reducing the frequency of administrations. A simple, fast and reproducible method by visible spectrophotometry was developed and validated for quantification of cefazolin sodium in the lyophilized powder. This technique is widely used in the pharmaceutical industry due to its ease of execution, low cost, safety and high precision and accuracy. It has been employed in the quality control routine of numerous pharmaceuticals in order to identify them and quantify their active principles. The method was capable of detecting and quantifying the cefazolin sodium obtaining satisfactory results regarding selectivity, precision, accuracy and robustness, on linear range of 32.0 to 92.0 µg mL -1 , showing the correlation coefficient of 0.9993 when analyzed at 767 nm. Due to the environmental impacts caused by global economic development, green chemistry has come up with a proposal to minimize and/or eliminate the use of harmful solvents, which generate large amounts of toxic waste to the environment and the health of operators, as well as reducing expenses with costly processes. The proposed method does not use toxic solvent, proving to be effective, low cost, easy to apply and safe for the analyst and environment. *Corresponding AuthorsFax: +55 16 3301 6967 E-Mail: ac_kogawa@yahoo.com.br [a]

show abstract

“…18 Conventional methods used for serum drug assays include gas chromatography, 19 polarography, 20 capillary electrophoresis, 21,22 and ultravioletvisible spectrophotometry. 23,24 However, these analytical methods do not appear to have widespread utility, especially at the industrial level, where simple, cost-effective, and highly specific methods are needed.…”

Section: Introductionmentioning

confidence: 99%

Novel HPLC method for quantitative determination of cefazolin sodium in pharmaceutical formulations

Hasan¹,

Sher²,

Siddiqui³

et al. 2013

RRMC

View full text Add to dashboard Cite

This paper reports a validated high-performance liquid chromatography method which is rapid, highly specific, and accurate for determination of cefazolin sodium in injectable pharmaceutical formulations. Separation was carried out using a Hibar ® µBondapak ® C 18 column with a mobile phase consisting of an acetonitrile to monobasic sodium phosphate buffer ratio of 17:83 and a flow rate of 1.0 mL per minute, and monitoring at a wavelength of 254 nm. The calibration curve was linear, with a correlation coefficient .0.9995 in the range of 5-100 µg/mL. Drug recovery was 98.35%-100.86%, with a limit of detection of 12.92 ng/mL and a limit of quantification of 43.09 ng/mL. The drug was subjected to stress conditions of hydrolysis (acid, base, oxidation, and thermal degradation), where maximum degradation was observed. Forced degradation studies confirmed stability indicating power of this method, which was validated in accordance with International Conference on Harmonization guidelines and used successfully to quantify the amounts of cefazolin sodium in bulk injectable formulations and in physiological fluid.

show abstract

Spectrophotometric and atomic absorption spectrometric determination of certain cephalosporins

Cited by 47 publications

References 21 publications

Spectrophotometric Determination Studies of Cefotaxime (CFX) and their CFX- Cd (II) and CFX- Cu (II) Complexes

Spectrophotometric Determination Studies of Cefotaxime (CFX) and their CFX- Cd (II) and CFX- Cu (II) Complexes

New Environmentally Friendly Method for Quantification of Cefazolin Sodium

Novel HPLC method for quantitative determination of cefazolin sodium in pharmaceutical formulations

Contact Info

Product

Resources

About