“…THE course of an experimental investigation of the toxicity of cobalt, the need arose for the determination of submicrogram quantities of this element in the tissues of animals exposed to cobalt metal fume at an air concentration approximating 1 mg. of cobalt per cubic meter. The purpose of the present paper is to present the two spectrochemical methods developed for the determination of cobalt (1) retained by the soft tissues of animals exposed to known concentrations of cobalt metal fume for specific periods of time or (2) deposited in the bones of exposed animals or present normally in the bone and soft tissues of unexposed animals. These methods have shown a high degree of sensitivity and accuracy on analyses of more than 1000 tissue samples from dogs, rabbits, guinea pigs, rats, and mice.…”