Spectro-analytical, antimicrobial and antitumor studies of the first and second generation of cephalosporin combined with ruthenium(III) ion as a drug model

Abstract

Two new ruthenium(III) complexes of 1 st (cefradine) and 2 nd (cefoxitin) generation of cephalosprin drugs have been synthesized and well characterized based on physical (molar conductance), spectral (FTIR & UV-Vis), thermal analysis (TGA & DTA) and analytical data. Both cefradine (ceph-1) and cefoxitin (ceph-2) act as a bidentate ligand and the synthesized complexes [Ru(L)(Cl) 2 (H 2 O) 2 ] where [L=cefradine and cefoxitin] are showing octahedral geometry. The analytical data refer to 1:1 (Ru 3+ /ceph) stoichiometry. FTIR analysis confirmed the coordination through the two oxygen atoms of β-lactam and carboxylate groups. The surface morphology and particle size investigations were evaluated using XRD, SEM and TEM analyses. The antimicrobial effect of ruthenium(III) ion upon complexity with ceph-1 and ceph-2 were assessed against Gram positive (Staphylococcus epidermidis & Staphylococcus aureus) and Gram negative (Klebsiella spp., Escherichia coli) bacterial strains. The potential anticancer properties of Ru 3+ cephalosprin complexes were evaluated in vitro on colorectal adenocarcinoma (Caco-2) and breast cancer (MCF-7) cell lines, indicating that the synthesized Ru(III) complexes are relatively better cytotoxic agents in comparison with cisplatin standard drug.

Complex of Ca(II) with Ceftriaxone: Synthesis, Structure, Spectral and Antibacterial Properties

“…Table 2 shows that the [CaCefTria]•4H 2 O did not have antibacterial activity against Pseudomonas aeruginosa and we observed the growth of bacteria. The increase of antibacterial activity of metal complex of ceftriaxone may play an important role in the inhibition of bacterial growth [39].…”