Spectrin (βSpIIΣ1) is an essential component of synaptic transmission

Sikorski, Aleksander F.; Sangerman, Jose; Goodman, Steven R.; Critz, Stuart D.

doi:10.1016/s0006-8993(99)02253-2

Cited by 56 publications

(47 citation statements)

References 21 publications

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“…Interestingly the six Ankyrin G in vivo O-GlcNAc-modified peptides identified in this study cluster in the middle of the serine/threonine-rich domain, a region implicated in axonal membrane targeting (46). A known O-GlcNAc-modified peptide from brain-specific Spectrin ␤2 (18), which links the cytoskeleton to synaptic vesicle release (47), was also identified here, and the exact site of O-GlcNAc modification on the peptide HDTSASTQSTPAS(S-OGlcNAc)R was determined in ECD MS analysis. Synaptopodin, linked with formation of dendritic spine apparatus and long term potentiation (48), was reported previously as OGlcNAc-modified (18).…”

Section: O-glcnac Modification Of Proteins From Mouse Postsynaptic Dementioning

confidence: 89%

O-Linked N-Acetylglucosamine Proteomics of Postsynaptic Density Preparations Using Lectin Weak Affinity Chromatography and Mass Spectrometry

Vosseller

Trinidad

Chalkley

et al. 2006

Molecular & Cellular Proteomics

316

335

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O-GlcNAc is a widespread dynamic carbohydrate modification of cytosolic and nuclear proteins with features analogous to phosphorylation. O-GlcNAc acts critically in many cellular processes, including signal transduction, protein degradation, and regulation of gene expression. However, the study of its specific regulatory functions has been limited by difficulties in mapping sites of O-GlcNAc modification. We report methods for direct enrichment and identification of in vivo O-GlcNAc-modified peptides through lectin weak affinity chromatography (

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Section: O-glcnac Modification Of Proteins From Mouse Postsynaptic Dementioning

confidence: 89%

O-Linked N-Acetylglucosamine Proteomics of Postsynaptic Density Preparations Using Lectin Weak Affinity Chromatography and Mass Spectrometry

Vosseller

Trinidad

Chalkley

et al. 2006

Molecular & Cellular Proteomics

316

335

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“…ELF could play a direct role in these processes of brain development through its involvement in cytoskeletal architecture, based on the appearance of the labeled cells. These observations are supported by the fact that spectrin comprises approximately 2.4% of total structural protein in mammalian brain homogenates (Davis and Bennett, 1983) is involved in the organization of presynaptic vesicles (Sikorski et al, 1991(Sikorski et al, , 2000, as well as in axonal transport (Levine and Willard, 1981).…”

Section: Elf Expression In Developing Mouse Brain Tissuesmentioning

confidence: 94%

ELF a β-spectrin is a neuronal precursor cell marker in developing mammalian brain; structure and organization of the elf/β-G spectrin gene

et al. 2002

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“…These observations are supported by the fact that spectrin comprises approximately 2.4% of total structural protein in mammalian brain homogenates (Davis and Bennett, 1983) and is involved in the organization of presynaptic vesicles (Sikorski and Goodman, 1991;Sikorski et al, 2000), as well as in axonal transport (Levine and Willard, 1981).…”

Section: Tgf-b and Elf (A B-spectrin)mentioning

confidence: 95%

TGF-β, Neuronal Stem Cells and Glioblastoma

Golestaneh

Mishra

2005

Oncogene

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Transforming growth factor beta (TGF-b) signaling leads to a number of biological end points involving cell growth, differentiation, and morphogenesis. Typically, the cellular effect accompanies an induction of mesodermal cell fate and inhibition of neural cell differentiation. However, during pathological conditions, these defined effects of TGF-b can be reversed; for example, the growthinhibitory effect is replaced with its tumor promoting ability. A multitude of factors and cross-signaling pathways have been reported to be involved in modulating the dual effects of TGF-b. In this review, we focus on the potential role of TGF-b signal transduction during development of neural progenitor cells and its relation to glioblastoma development from neural stem cells.

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Spectrin (βSpIIΣ1) is an essential component of synaptic transmission

Cited by 56 publications

References 21 publications

O-Linked N-Acetylglucosamine Proteomics of Postsynaptic Density Preparations Using Lectin Weak Affinity Chromatography and Mass Spectrometry

O-Linked N-Acetylglucosamine Proteomics of Postsynaptic Density Preparations Using Lectin Weak Affinity Chromatography and Mass Spectrometry

ELF a β-spectrin is a neuronal precursor cell marker in developing mammalian brain; structure and organization of the elf/β-G spectrin gene

TGF-β, Neuronal Stem Cells and Glioblastoma

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