Spectrally selective 3D TSE imaging of phosphocreatine in the human calf muscle at 3 T

Parasoglou, Prodromos; Xia, Ding; Regatte, Ravinder R.

doi:10.1002/mrm.24288

Cited by 20 publications

(33 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The software has been used in more than 50 peer‐reviewed journal articles in diverse areas of NMR research. The applications include dynamic measurement of blood oxygenation and blood velocity , measurement of pulse‐wave velocity , simultaneous T2* and perfusion quantification in the leg , vessel wall imaging , high‐resolution imaging of trabecular bone , sodium imaging at the knee , MR elastography , spectrally selective 3D fast spin echo , dynamic imaging of phosphocreatine recovery kinetics , and solid‐state 1 H and 31 P cortical bone imaging . Despite the commonalities between many of the sequences for these applications, each of the above techniques required individual customization.…”

Section: Resultsmentioning

confidence: 99%

Pulse sequence programming in a dynamic visual environment: SequenceTree

Magland

Langham

et al. 2015

Magnetic Resonance in Med

View full text Add to dashboard Cite

Purpose To describe SequenceTree (ST), an open source. integrated software environment for implementing MRI pulse sequences, and ideally exported them to actual MRI scanners. The software is a user-friendly alternative to vendor-supplied pulse sequence design and editing tools and is suited for non-programmers and programmers alike. Methods The integrated user interface was programmed using the Qt4/C++ toolkit. As parameters and code are modified, the pulse sequence diagram is automatically updated within the user interface. Several aspects of pulse programming are handled automatically allowing users to focus on higher-level aspects of sequence design. Sequences can be simulated using a built-in Bloch equation solver and then exported for use on a Siemens MRI scanner. Ideally other types of scanners will be supported in the future. Results The software has been used for eight years in the authors’ laboratory and elsewhere and has been utilized in more than fifty peer-reviewed publications in areas such as cardiovascular imaging, solid state and non-proton NMR, MR elastography, and high resolution structural imaging. Conclusion ST is an innovative, open source, visual pulse sequence environment for MRI combining simplicity with flexibility and is ideal for both advanced users and those with limited programming experience.

show abstract

Section: Resultsmentioning

confidence: 99%

Pulse sequence programming in a dynamic visual environment: SequenceTree

Magland

Langham

et al. 2015

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

“…A summary of the human studies using PCr imaging techniques is listed in Table 1. Shown in Figure 6 are maps of PCr distribution in human calf muscle acquired at 3T using spectrally selective 3D turbo spin-echo (TSE) method (75). In addition to PCr, maps of P i (154) and PCr-to-ATP ratio (155) can also be acquired.…”

Section: Spectrally Selective Imaging Methodsmentioning

confidence: 99%

“…However, the voxel size is still an order of magnitude larger than that of 1 H-MRI, even at Figure 6 Representative PCr concentration maps of healthy human calf muscle (A) and corresponding 1 H anatomical slices (B) acquired using spectrally selective 3D TSE imaging method. Reproduced with permission from Parasoglou et al (75). TSE, turbo spin-echo.…”

Section: Spectrally Selective Imaging Methodsmentioning

confidence: 99%

“…The accurate estimation of the correction factor requires the measurements of B 1 field map of the 31 P transceiver coil, which is much more time consuming than B 1 mapping in 1 H-MRI. A study on human calf muscle reported >1 hour acquisition time to acquire a B 1 map for a 31 P volume coil (75). Hence, the external reference approach is not always practical.…”

Section: P-mrsmentioning

confidence: 99%

See 1 more Smart Citation

Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review

Liu

2017

Quant. Imaging Med. Surg.

View full text Add to dashboard Cite

Many human diseases are caused by an imbalance between energy production and demand.Magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) provide the unique opportunity for in vivo assessment of several fundamental events in tissue metabolism without the use of ionizing radiation. Of particular interest, phosphate metabolites that are involved in ATP generation and utilization can be quantified noninvasively by phosphorous-31 ( 31 P) MRS/MRI. Furthermore, 31 P magnetization transfer (MT) techniques allow in vivo measurement of metabolic fluxes via creatine kinase (CK) and ATP synthase. However, a major impediment for the clinical applications of 31 P-MRS/MRI is the prohibitively long acquisition time and/or the low spatial resolution that are necessary to achieve adequate signal-to-noise ratio. P-MRS/MRI techniques. Applications of these techniques to the investigation of a specific physiology/pathology will be discussed without detailed description. Interested readers are referred to recent review articles on the applications of 31 P-MRS/MRI in metabolic characterization of skeletal muscle (10-12), heart (13), brain (14), and liver (11), as well as in diseases such as cancer (15), heart failure (16), and obesity and diabetes (17,18). Historical perspectiveThe use of 31 P-MRS for metabolic investigations dates back to 1960. Cohn and Hughes were the first to obtain a high-resolution 31 P spectrum of a solution of ATP (19). In addition, they also observed a dependence of the chemical shifts of the phosphorus nuclei of ATP on the pH of the solution. In parallel to the early development of MRI methods by Lauterbur (20), the entire 1970s also witnessed the rapid advance of 31 P-MRS in metabolic investigation of a broad range of biological systems. In 1973, Moon and Richards performed the first 31 P-MRS study that measured intracellular pH in human red blood cells (21). In the following year, Henderson and colleagues obtained the first 31 P spectrum of ATP from human red blood cells (22). At the same time, the Oxford team led by Radda performed the first experiment to acquire 31 P spectra from an intact organ, i.e., the excised and superfused muscle of rat hindlimb (23). The first in vivo 31 P-MRS study was performed on mouse brain by Chance et al. (24). Within the short span of one decade, organelles including mitochondria (25,26) and chromaffin granules (27), cells including Escherichia coli (28), yeast (29), and hepatocytes (30), and organs including skeletal muscle (31,32), heart (33-35), brain (36), kidney (37), and liver (38,39) have all been studied using 31 P-MRS.It is worth noting that most of these organ studies were performed on excised organs to avoid the need for spatial localization. Although Lauterbur has demonstrated the feasibility of imaging water protons (20), it was considered impractical for 31 P imaging of living systems because of the low sensitivity and difficulties with spectral resolution.The 1980s began with the publication of two important studies that aimed a...

show abstract

“…Also the feasibility of direct 31 P mapping has been demonstrated although the spatial resolution was limited. To overcome the low in vivo SNR per unit time, several approaches were proposed including turbo spin echo (TSE) [15][16][17][18], fast low angle shot (FLASH) [19,20], or balanced steady-state free precession (bSSFP) [21,22] sequences.…”

Section: Introductionmentioning

confidence: 99%