Spectral Transmission of the Human Crystalline Lens in Adult and Elderly Persons: Color and Total Transmission of Visible Light

Artigas, José María Gatell; Felipe, Adelina; Navea, Amparo; Fandiño, Adriana; Artigas, Cristina

doi:10.1167/iovs.12-9471

Cited by 128 publications

(152 citation statements)

References 21 publications

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“…In this study, pupillary constriction responses to blue light were not selectively reduced in aging or in the presence of cataract, even though it is well established that more blue light is absorbed by the lens in older individuals613141516. Our findings are consistent with a recent study in which the magnitude of sustained pupillary constriction responses to blue light and green light stimuli (480 nm and 550 nm; 12.8, 13.5, or 14.0 log photons cm −2 s −1 ) did not differ between young and older subjects (18–30 years versus ≥55 years)17.…”

Section: Discussionmentioning

confidence: 53%

Pupillary responses to short-wavelength light are preserved in aging

Rukmini

Miléa

Aung

et al. 2017

Sci Rep

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With aging, less blue light reaches the retina due to gradual yellowing of the lens. This could result in reduced activation of blue light-sensitive melanopsin-containing retinal ganglion cells, which mediate non-visual light responses (e.g., the pupillary light reflex, melatonin suppression, and circadian resetting). Herein, we tested the hypothesis that older individuals show greater impairment of pupillary responses to blue light relative to red light. Dose-response curves for pupillary constriction to 469-nm blue light and 631-nm red light were compared between young normal adults aged 21–30 years (n = 60) and older adults aged ≥50 years (normal, n = 54; mild cataract, n = 107; severe cataract, n = 18). Irrespective of wavelength, pupillary responses were reduced in older individuals and further attenuated by severe, but not mild, cataract. The reduction in pupillary responses was comparable in response to blue light and red light, suggesting that lens yellowing did not selectively reduce melanopsin-dependent light responses. Compensatory mechanisms likely occur in aging that ensure relative constancy of pupillary responses to blue light despite changes in lens transmission.

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Section: Discussionmentioning

confidence: 53%

Pupillary responses to short-wavelength light are preserved in aging

Rukmini

Miléa

Aung

et al. 2017

Sci Rep

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“…4 In terms of the IOL color, a clear lens has greater light transmittance than a yellow-colored IOL and thus the effect on circadian rhythm synchronization may be stronger. [43][44][45] Sleep quality is affected by many physiological and mental factors, as is photo-entrainment calculated from the IOL spectral transmission.…”

Section: Discussionmentioning

confidence: 99%

Rejuvenation Effects of Cataract Surgery with Ultraviolet Blocking Intra-Ocular Lens on Circadian Rhythm and Gait Speed

Ayaki

Negishi

Tsubota

2014

Rejuvenation Research

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Background: Previously, we reported improvements in sleep quality and gait speed after implantation of a yellow-colored, blue light-blocking intra-ocular lens (IOL). This study evaluated systemic health parameters for 7 months after cataract surgery with implantation of a clear, ultraviolet (UV)-blocking IOL. Methods: A total of consecutive 71 patients (average age 74.1 years) underwent cataract surgery with the implantation of a clear, UV-blocking IOL. Participants were evaluated using the Pittsburgh Sleep Quality Index (PSQI) and the National Eye Institute Visual Function Questionnaire (VFQ-25) before and at 2 and 7 months after surgery. Four-meter gait speed was also determined. The metabolic parameters of serum glycated hemoglobin (HbA1c), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were tested. Results: The pre-operative and post-operative (2 and 7 months after surgery) results were 66.4 -16.5, 79.5 -12.6, and 81.0 -13.0 for VFQ-25 score, 5.7 -3.5, 5.1 -3.1, and 4.8 -2.9 for PSQI, and 0.90 -0.22, 0.91 -0.22, and 0.92 -0.22 meters/sec for gait speed. Significant improvements following surgery were noted in the VFQ-25 score for all cases and in the PSQI for poor sleepers (preoperative PSQI > 5.5) (P < 0.05, paired t-test). The gait speed and metabolic parameters showed no significant changes. Conclusions: Cataract surgery with implantation of an UV-blocking clear IOL has the potential for improving circadian rhythm and systemic health parameters.

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“…With increasing age and in the presence of systemic or ocular disease, media transmission is invariably altered (Wuerger 2013, Sakanishi et al 2012, Artigas et al 2012, Bron et al, 2000, Polo et al, 1996. This change in ocular media transparency and scattering effect (light diffusion) produced by a cataract can affect both spectral transmission and morphology.…”

Section: Introductionmentioning

confidence: 99%

The effect of simulated cataract light scatter on retinal vessel oximetry

Patel

Hudson

Flanagan

et al. 2013

Experimental Eye Research

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To assess the impact of light scatter, similar to that introduced by cataract on retinal vessel blood oxygen saturation measurements using poly-bead solutions of varying concentrations.Eight healthy, young, non-smoking individuals were enrolled for this study. All subjects underwent digital blood pressure measurements, assessment of non-contact intraocular pressure, pupil dilation and retinal vessel oximetry using dual wavelength photography (Oxymetry Modul, Imedos Systems, Germany). To simulate light scatter, cells comprising a plastic collar and two plano lenses were filled with solutions of differing concentrations (0.001, 0.002 and 0.004%) of polystyrene microspheres (Polysciences Inc., USA). The adopted light scatter model showed an artifactual increase in venous optical density ratio (p=0.036), with the 0.004% condition producing significantly higher venous optical density ratio values when compared to images without a cell in place. Spectrophotometric analysis, and thus retinal vessel oximetry of the retinal vessels, is altered by artificial light scatter.

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Spectral Transmission of the Human Crystalline Lens in Adult and Elderly Persons: Color and Total Transmission of Visible Light

Cited by 128 publications

References 21 publications

Pupillary responses to short-wavelength light are preserved in aging

Pupillary responses to short-wavelength light are preserved in aging

Rejuvenation Effects of Cataract Surgery with Ultraviolet Blocking Intra-Ocular Lens on Circadian Rhythm and Gait Speed

The effect of simulated cataract light scatter on retinal vessel oximetry

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