Spectral Study on the Interactions Among Cu(II), Doxorubicin and CopC

Yunxi, Song; Song, Zilin; Yang, Binsheng

doi:10.1007/s40242-019-8284-5

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…Äàííûé ïðåïàðàò ïðîÿâëÿë âûðàaeåííóþ àíòèñòðåññîâóþ àêòèâíîñòü [27]. Áûëî ïîêàçàíî, ÷òî çà ñ÷åò âûäåëåííûõ ïòåðîêàðïàíîâûõ ãëèêîçèäîâ C. jubata îáëàäàåò ïðîòèâîîïóõîëåâîé àêòèâíîñòüþ â îòíîøåíèè 2 êëåòî÷íûõ ëèíåé îïóõîëåé A549 è P388 [28].…”

Section: ôàðìàêîëîãè÷åñêàÿ àêòèâíîñòü C Jubataunclassified

Потенциальная биологическая активность и химический состав растения <i>Caragana jubata</i> (Pall.) Poir. (обзор)

Какорин¹,

Tereshkina²,

Раменская³

2018

Хим.-фарм. ж.

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Проанализированы данные литературы по вопросу химического состава и биологической активности Caragana jubata (Pall.) Poir. — караганы гривастой семейства Fabaceae (бобовые) — нового потенциально перспективного источника лекарственного растительного сырья, широко применяемого в народной медицине России. Проведены собственные пилотные экспериментальные исследования состава биологически активных веществ и фармакологической активности водного извлечения надземной части C. jubata. На основании анализа литературных данных и результатов собственных экспериментальных исследований можно сделать вывод о том, что доминирующей фракцией биологически активных веществ караганы гривастой являются полифенольные соединения (флавоноиды), преимущественно моно- и дигликозиды, являющиеся производными О-гидроксилированных флавонолов. Согласно литературным данным, карагана гривастая может обладать гепатопротекторной и противовирусной активностью. В результате наших исследований выявлена антиоксидантная активность водного извлечения надземной части C. jubata в условиях in vitro, противовоспалительная и ранозаживляющая активность и отсутствие антибактериальной активности в отношении некоторых фармакопейных штаммов. На основании проведенных информационно-аналитических и экспериментальных исследований C. jubata можно рекомендовать для дальнейшего изучения доклинической и клинической эффективности и безопасности как перспективного лекарственного растения.

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Section: ôàðìàêîëîãè÷åñêàÿ àêòèâíîñòü C Jubataunclassified

Потенциальная биологическая активность и химический состав растения <i>Caragana jubata</i> (Pall.) Poir. (обзор)

Какорин¹,

Tereshkina²,

Раменская³

2018

Хим.-фарм. ж.

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“…The UV spectrum showed absorption maximum at 235, 285, 305 nm, typical absorptions of pterocarpanes. 14 The 1 H-NMR spectrum disclosed signals (Table 1) On the basis of above partial structures, the molecular framework was constructed by the HMBC analysis (Fig. 2).…”

mentioning

confidence: 99%

“…The absolute configuration of 1 was, therefore, determined to be 6aR,11aR-, the same as that of maackiain. 14 The potential GLUT-4 translocation activity of compounds 1-13 was tested against pIRAP-mOrange cDNAs transfected L6 cells . [9][10][11][12] Insulin (100 nM) was used as the positive control.…”

mentioning

confidence: 99%

Chemical constituents from Sophora tonkinensis and their glucose transporter 4 translocation activities

Yang

Deng

et al. 2017

Bioorganic & Medicinal Chemistry Letters

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Bioassay-guided phytochemical investigation of the EtOAc fraction (ST-EtOAc) from the roots of Sophora tonkinensis resulted in the isolation of a new compound 6aR,11aR-1-hydroxy-4-isoprenyl-maackiain (1), along with 12 known compounds (2-13). The structure of the new compound was established by 1D and 2D NMR, MS data and circular dichroism analysis. Polyprenylated flavonoids 6-9 and 11-13 increased GLUT-4 translocation by the range of 1.35-2.75 folds. Sophoranone (8) exerted the strongest activity with 2.75 folds GLUT-4 translocation enhancement at the concentration of 10μM. This is the first report of the GLUT-4 translocation activity of the plant Sophora tonkinensis.

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Acid-Triggered Self-Assembled Egg White Protein-Coated Gold Nanoclusters for Selective Fluorescent Detection of Fe³⁺, NO₂^–, and Cysteine

Wen

Zhao

et al. 2020

ACS Appl. Nano Mater.

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Herein, we present a simple and economical synthesis for the first multianalyte probe able to selectively quantify the concentrations of Fe3+, NO2 –, and cysteine. It comprises H+-triggered self-assembled gold nanoclusters (AuNCs@EW/H+, AuEHs), showing enhanced red fluorescence at 640 nm. The AuEH is a good fluorescent nanosensor for Fe3+ and NO2 – with detection limits of 1.40 and 2.82 nM, respectively. Iron detection, through fluorescence quenching, occurs because of nanocluster aggregation elicited by the complexation of Fe3+ with amino acids on the surface of AuEH; nitrite detection likely proceeds through fluorescence quenching via the disassembly of the nanoclusters following irreversible oxidation by nitrite. This selectivity is good enough that it can be used to quantify the nitrite concentration in commercially available processed meat. Cysteine detection occurs through the restoration of fluorescence of iron-quenched samples; similar molecules including homocysteine and glutathione are unable to restore fluorescence, showing the specificity of the interaction. Applications, including as a detecting ink and as a biocompatible probe, show promise because of the lack of observable toxicity of the AuEHs, demonstrating their promise as specific and sensitive biosensors.

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Spectral Study on the Interactions Among Cu(II), Doxorubicin and CopC

Cited by 3 publications

References 29 publications

Потенциальная биологическая активность и химический состав растения <i>Caragana jubata</i> (Pall.) Poir. (обзор)

Потенциальная биологическая активность и химический состав растения <i>Caragana jubata</i> (Pall.) Poir. (обзор)

Chemical constituents from Sophora tonkinensis and their glucose transporter 4 translocation activities

Acid-Triggered Self-Assembled Egg White Protein-Coated Gold Nanoclusters for Selective Fluorescent Detection of Fe³⁺, NO₂^–, and Cysteine

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Spectral Study on the Interactions Among Cu(II), Doxorubicin and CopC

Cited by 3 publications

References 29 publications

Потенциальная биологическая активность и химический состав растения <i>Caragana jubata</i> (Pall.) Poir. (обзор)

Потенциальная биологическая активность и химический состав растения <i>Caragana jubata</i> (Pall.) Poir. (обзор)

Chemical constituents from Sophora tonkinensis and their glucose transporter 4 translocation activities

Acid-Triggered Self-Assembled Egg White Protein-Coated Gold Nanoclusters for Selective Fluorescent Detection of Fe3+, NO2–, and Cysteine

Contact Info

Product

Resources

About

Acid-Triggered Self-Assembled Egg White Protein-Coated Gold Nanoclusters for Selective Fluorescent Detection of Fe³⁺, NO₂^–, and Cysteine