Spectral studies on the structure and monovalent cation binding to poly(1,3-propylene phosphate) ? a synthetic analogue of natural teichoic acids

Ostrowska-Czubenko, Jadwiga

doi:10.1007/bf01410155

Cited by 5 publications

(1 citation statement)

References 16 publications

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“…[25][26][27] It is established that the P@O group of poly (hydroxyalkylene phosphate) participates in hydrogen bonding with PAOH and OH groups. [28][29][30] Besides, poly(hydroxyoxyethylene phosphate)s are biodegradable, biocompatible, water soluble and low toxic polymers. 31 Polyphosphoesters degraded through hydrolysis of the PAOAC ester bonds under acidic or basic conditions [31][32][33] and this can be particularly accelerated in the presence of phosphoesterase.…”

Section: Introductionmentioning

confidence: 99%

Polyphosphoester‐based paclitaxel complexes

Mitova

Hristova

Cherkezova

et al. 2015

J of Applied Polymer Sci

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We demonstrated a feasible approach for the preparation of a biodegradable, water soluble polyphosphoester based paclitaxel complex. Applying poly(hydroxyoxyethylene phosphate) which contains both a strong proton accepting PO group and a proton donating POH group, paclitaxel has been physically immobilized onto the polymer via H‐bonding. The water soluble complex contained 16.7 wt % paclitaxel and more than 4000 times increased drug solubility was achieved. The polymer‐drug complex formed nanosized aggregates that were characterized by dynamic light scattering. Intravenous injection of poly(hydroxyoxyethylene phosphate) in rats at a dose of 1000 mg/kg did not induce any clinical signs or body weight gain reduction. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42772.

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Section: Introductionmentioning

confidence: 99%

Polyphosphoester‐based paclitaxel complexes

Mitova

Hristova

Cherkezova

et al. 2015

J of Applied Polymer Sci

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Preparation and characterization of membranes with positively charged main chain from polyethylenimine

Nagaya

Tanioka

Miyasaka

1993

J of Applied Polymer Sci

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SYNOPSISA membrane, which has positively charged groups in the polymer main chain, was prepared from polyethylenimine by crosslinking and successive alkylation. Dibromoalkane was used as a crosslinking agent. The crosslinked membrane was alkylated using methyl iodide under several conditions. Elemental and ICP emission analyses were introduced to measure the rates of alkylation and quaternization. From the membrane potential measurement, the effective charge density was estimated. The highest value was about 1.0 M, which was obtained by a prolonged alkylation time. This value was larger than that of some commercial ion exchange membranes. The effective charge density, which was obtained by the last alkylation procedure, was 10 times larger than that of the former one, though the rate of quaternizing increased by less than a factor of two. This implies that the activity constant in the membrane increased when the charge density is increased.

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Competitive counterion binding to poly(alkylene phosphate)s related to natural teichoic acids. The Poisson‐Boltzmann approach

Ostrowska-Czubenko

Czubenko

1997

Ber Bunsenges Phys Chem

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The problem of competitive metal ion binding to poly(alkylene phosphate)s, considered as synthetic models of natural teichoic acids, was analysed theoretically applying the Poisson‐Boltzmann (PB) equation to a cylindrical cell model. There were calculated the radial distribution functions as well as the degree of ion binding of mono‐and divalent metal ions to polyphosphate ions in solutions of different concentrations ranging from 10−5 M to 10−2 M and containing different amounts of M⊕ and M2+ counterions. For comparison, analogous calculations were performed also for poly(styrenesulfonate)s. The results indicate the preferential binding of divalent metal ions to polyphosphate ions over monovalent ones. The selectivity for M2+ ions is concentration dependent and increases with decreasing the polymer solution concentration. It results from PB calculations, that condensation of divalent metal ions at the surface of polyion chains seems to be responsible for preferential binding of biologically important metal ions, for example magnesium, to natural teichoic acids and their synthetic analogues.

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Spectral studies on the structure and monovalent cation binding to poly(1,3-propylene phosphate) ? a synthetic analogue of natural teichoic acids

Cited by 5 publications

References 16 publications

Polyphosphoester‐based paclitaxel complexes

Polyphosphoester‐based paclitaxel complexes

Preparation and characterization of membranes with positively charged main chain from polyethylenimine

Competitive counterion binding to poly(alkylene phosphate)s related to natural teichoic acids. The Poisson‐Boltzmann approach

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