Spectral Range Optimization to Enhance the Effectiveness of Phototherapy for Neonatal Hyperbilirubinemia

Plavskiĭ, V. Yu.; Микулич, А. В.; Leusenko, I. A.; Tret’yakova, A. I.; Plavskaya, L. G.; Serdyuchenko, N. S.; Gao, Jing; Xiong, Daxi; Wu, Xiaodong

doi:10.1007/s10812-017-0433-3

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…Установлено, что расширение спектрального диапазона излучения (рис. 6) за счет добавления к свету синего диапазона с λ max ≈ 462 нм зеленой компоненты с λ max ≈ 505 нм (в условиях одинаковой интегральной плотности мощности) приводит к повышению эффективности снижения уровня общего билирубина в крови новорожденных детей [18].…”

Section: зависимость терапевтического действия светодиодных источникоunclassified

“…Наблюдаемый эффект обусловлен гетерогенностью спектральных характеристик билирубина в условиях различного микроокружения, а также зависимостью оптимальной длины волны излучения для фотоизомеризации пигмента от глубины залегания кровеносных сосудов, являющихся местом протекания реакций фототрансформации билирубина. Причинами гетерогенности спектральных характеристик билирубина являются: локализация билирубина в 2-3 различных сайтах молекулы альбумина, способного к тому же находиться в различном агрегатном состоянии как в сосудистом, так и внесосудистом руслах; существенное влияние жирных кислот и лекарств, связанных с альбумином, на структуру билирубина [18]. Кроме того, расширение спектрального диапазона воздействующего излучения за счет добавления зеленой компоненты приводит к увеличению облучаемых объемов крови, в которых инициируются реакции фотоизомеризации с повышенным квантовым выходом люмирубина, лежащие в основе терапевтического действия света при лечении гипербилирубинемии.…”

Section: зависимость терапевтического действия светодиодных источникоunclassified

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New approaches to improve efficacy and reduce side effects of phototherapy for neonatal hyperbilirubinemia using led and laser sources

2019

Photobiology and Photomedicine

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The article discusses the new opportunities for improving technology of phototherapy for neonatal jaundice using LED and laser sources in order to reduce the level of bilirubin in the blood of infants. It has been shown that several types of LEDs with emission spectrum corresponding to the long-wavelength slope of bilirubin absorption band can be used for therapeutic purposes. At the same time, the efficacy of phototherapy depend on not only from the position of the maximum in emission spectrum of the LEDs within bilirubin absorption band, but also on the spectral width of acting radiation. Based on the study of regularities of infl of optical radiation on the survival of animal cells in culture sensitized with bilirubin it has been concluded that the damaging eff cts are signifi ly reduced upon transition from quasi-monochromatic LED sources to lasers, emitting in the same spectral range. It allows to consider the modern semiconductor lasers emitting in blue and blue-green spectral regions as promising sources for development of phototherapeutic equipment for treating neonatal hyperbilirubinemia.

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Section: зависимость терапевтического действия светодиодных источникоunclassified

New approaches to improve efficacy and reduce side effects of phototherapy for neonatal hyperbilirubinemia using led and laser sources

2019

Photobiology and Photomedicine

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Evaluation of a new calibration method for bilirubinometers measurements

Faramawy

2023

Review of Scientific Instruments

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Although bilirubin meters are still continuously widely used to screen neonatal jaundice worldwide, they still need a metrological calibration method to evaluate the measurement accuracy of these kinds of devices. In this article, the author describes a new calibration method for evaluation of the bilirubinometers measurements and evaluates the results with one of the most common statistical metrological techniques to establish and evaluate the calibration method; the techniques are x̄ and R control charts. The method mainly depends on establishing a correlation between two units, the bilirubin unit (mg/dl) and one of the metrological standard SI units, the irradiance (W/cm2), experimentally to achieve the calibration method. The study results showed that the estimated correlation coefficient of irradiance response to the bilirubinometer under test was around 0.80, which is a primary indication that the method is a considerably valid technique. In addition, the calibration method was evaluated by the statistical parameters x̄ and R control charts, and the results concluded that the variability calibration process is stable, controlled, and hence could be promisingly utilized to evaluate various bilirubinometers with satisfied accuracy and precision in measurements.

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Study of photobiomodulation effects with violet-blue and red light in experimental oncogenesis

Жукова¹,

Щербатюк

Potapov

et al. 2020

Med. tr. prom. èkol.

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Introduction. There is still an open question about the limits of medical use of low-intensity electromagnetic radiation of the optical range in tumor growth due to the risk of increased proliferation of tumor cells. The conditions under which the tumor process is stimulated, as well as the mechanisms of photobiomodulation in oncological pathology, remain unclear. The aim of the study - in vitro evaluation and comparison of the effect of low-intensity electromagnetic radiation with wavelengths of 400, 460 and 660 nm on the activity of free-radical processes in tumor tissue and blood in normal and growing experimental neoplasia. Materials and methods. The study was conducted on biological material obtained from white non-linear rats intact and with subcutaneously transplanted cholangiocellular cancer MS-1. The sources of low-intensity radiation with wavelengths of 400, 460 and 660 nm were led generators. The content of hemoglobin, the activity of superoxide dismutase and catalase, changes in the overall level of free radical processes and antioxidant activity by induced chemiluminescence, and DNA damage by the method of DNA comets were studied. Data analysis was performed using nonparametric statistics methods. Results. The multidirectional effect of radiation with wavelengths of 400, 460 and 660 nm on free-radical homeostasis indicators at the early and late stages of tumor growth, as well as the dependence of biological effects on the wavelength of radiation, was found. Conclusions. The results obtained allow making a number of assumptions about the mechanisms of action of the optical electromagnetic waves on tumor growth, modulating free radical processes in the tumor-bearing organism.

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Spectral Range Optimization to Enhance the Effectiveness of Phototherapy for Neonatal Hyperbilirubinemia

Cited by 3 publications

References 51 publications

New approaches to improve efficacy and reduce side effects of phototherapy for neonatal hyperbilirubinemia using led and laser sources

New approaches to improve efficacy and reduce side effects of phototherapy for neonatal hyperbilirubinemia using led and laser sources

Evaluation of a new calibration method for bilirubinometers measurements

Study of photobiomodulation effects with violet-blue and red light in experimental oncogenesis

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