Spectral methods to estimate the strength of intermolecular interactions in liquids

Dimitriu, Mihaela; Babusca, Daniela; Angheluta, Ecaterina; Dorohoi, Dana Ortansa; Dimitriu, Dan Gheorghe

doi:10.1080/15421406.2022.2066796

Cited by 1 publication

(2 citation statements)

References 19 publications

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“…The phenomena of solvatochromism was discovered in the action of pharmacological solutions; the name solvatochromism is employed to describe the claimed shift in wave length and absorbance of a UVvisible absorption band owing to a change in medium polarity. When absorption spectrum in various solutions were studied, it was observed that the type of the solvent affected not only the wave length of the absorption peak but also its intensity and, in some cases, its shape [20].…”

Section: Methodsmentioning

confidence: 99%

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Determination of Free Chemical Potential for Finasteride Diffusion through SDS Micelle Suggested as Alternative Living Membrane System

Hatem

Obaid

2022

IJMST

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As an alternative living cell membrane, sodium dodecyl sulfide (SDS) has been investigated at this study, spectroscopic assessment of Finasteride diffusion through the alternate model of the cell membrane in two distinct polar solutions, buffer phosphate solution pH 7.4 and Cyclohexane(Non-polar solution), has been studied. Finasteride in buffer phosphate solution showed a definite ?max at 253 nm, which was consistent with the default values. The results also reveal that the non-polar medium has a lower attenuation coefficient and a shorter maximum wavelength than the polar medium. The pH 7.4 finasteride solution demonstrated remarkable stability over time. Diffusion rate of Finasteride was investigated using Sodium Dodecyl Sulfate (SDS) as an alternative cell membrane model. The chemical potential was determined to be - 6294.76 J mol-1, showing the spontaneity of the compound's diffusion process. The results indicated that Finasteride may diffuse (at a rate constant of 51.11 min-1) from the aqueous media and other identified components to the inner micelle; the equilibrium constant for diffusion was calculated to be 11.5. Keywords: Finasteride, Diffusion, Chemical potential, SDS, Alternative model, Cell membrane.

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Section: Methodsmentioning

confidence: 99%

“…The sensitivity to the solvent polarity could be used to understand spectrum shifts in systems without an intermolecular hydrogen bond. As a result, raising the polarity of the solvent causes a bathochromic shifting of the bands (π-π*) in many molecules [20,23].…”

Section: Spectroscopic Study Of Finasteridementioning

confidence: 99%

Determination of Free Chemical Potential for Finasteride Diffusion through SDS Micelle Suggested as Alternative Living Membrane System

Hatem

Obaid

2022

IJMST

View full text Add to dashboard Cite

show abstract

Spectral methods to estimate the strength of intermolecular interactions in liquids

Cited by 1 publication

References 19 publications

Determination of Free Chemical Potential for Finasteride Diffusion through SDS Micelle Suggested as Alternative Living Membrane System

Determination of Free Chemical Potential for Finasteride Diffusion through SDS Micelle Suggested as Alternative Living Membrane System

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