Spectral, Magnetic and Antimicrobial Studies of Co(II), Ni(II) and Cu(II) Complexes with Bidentate Schiff Base Ligands

Abstract

Prevention of disease by the development of active treatments that control illness with minimum side effect to the human being has become the vital goal of modern health care. The use of antibiotics in medicine has resulted in an increasing number of resistant strains of microorganism, through mutation and gene transfer. Medical research has proved through extensive evidence that most of the diseases are mainly . On the basis of molar conductance data complexes are proposed non-electrolytic in nature. On the basis of physicochemical and spectroscopic studies, the structure of the Co(II), Ni(II) and Cu(II) complexes was proposed octahedral in nature. All the synthesized ligand and complexes have been screened for antimicrobial activity.

Valence Bond Sum (VBS) Analysis on Bis(dithiocarbamato) Nickel (II) and Complexes with NiS4 Chromophore

“…The chemist wishing to estimate an unknown bond length in a molecule or crystal is confronted with an intimidating array of covalent radii, ionic radii, metallic radii etc., from which to choose 1 . The bond valence method [2][3][4] has recently had considerable success in predicting and interpreting bond lengths in 'ionic ORIENTAL JOURNAL OF CHEMISTRY www.orientjchem.org solids'. As it can be applied to estimate the bond lengths, vice-versa the sum of these bond lengths should give information about the valence of the central ion.…”

Synthesis, Physico-chemical, Spectral and Hypoglycemic Activity of Samarium Complex of Glimepiride, An Oral Antidiabetic Drug

“…The Glimepiride metal complex showed a prominent IR absorption band in the region 1706 cm -1 and 1702 cm -1 due to (C=O) carbonyl group [28][29] . The next IR band of structure significance of the ligand appears at 1215 cm -1 which may be assigned to (S=O) which got shifted at 1216 cm -1 in the complex.…”

Synthesis, Characterization and Antidiabetic Study of Nd (III) Complex of 1-(p-(2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)Ethyl) Phenyl)Sulfonyl)-3-(trans-4-methyl Cyclohexyl) Urea Amaryl or Glimepiride, An Oral Antidiabetic Drug

“…The Glimepiride metal complex showed a prominent IR absorption band in the region 1706cm -1 and 1701cm -1 due to (C=O) carbonyl group [28][29] . The next IR band of structure significance of the ligand appears at 1215cm -1 which may be assigned to (S=O) which got shifted at 1216cm -1 in the complex.…”

“…DMSO was used as a solvent. The other features of NMR spectrum were the aromatic proton resonances located and the presence of unresolved multiplet is suggestive of excessive deshielding of aromatic protons [26][27][28][29][30] . The NMR signal of enolic OH group is observed in the ligand while absent in the complex indicates the involvement of enolic OH group in complexation.…”