Spectral homogeneity of human platelets investigated by SERS

Abstract

This paper describes a detailed study of the spectral homogeneity of human platelets using Surface-enhanced Raman spectroscopy (SERS). We used a combined approach based on multivariate methods as principal component analysis and pair correlation algorithms to investigate platelets spectral properties. The correlation coefficients for each sample have been calculated, and the average coefficient of determination has been estimated. The high degree of spectral homogeneity inside one probe and between them has been revealed. The prospects of obtained results usage for pathologies based on platelet conformations during cardiovascular diseases have been demonstrated.

Raman spectra simulation of antiplatelet drug-platelet interaction using DFT

“…All healthy volunteers were divided into 3 groups: 11 subjects without antiplatelet therapy, 8 subjects after taking 100 mg aspirin, and 4 subjects after taking 300 mg clopidogrel. The preparation protocol was based on 11 . Briefly, fresh venous blood samples were taken from healthy volunteers in vacuum tubes containing EDTA (BD Vacutainer® spray-coated K2 EDTA Tubes).…”