Spectral fingerprints of correct vestibular discrimination of the intensity of body accelerations

Ertl, Matthias; Klaus, Manuel Patrick; Mast, Fred W.; Brandt, Thomas; Dieterich, Marianne

doi:10.1016/j.neuroimage.2020.117015

Cited by 10 publications

(19 citation statements)

References 44 publications

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“…The most active areas during vestibular stimulation by means of distributed source localization were area CSv, the posterior opercular-insular region, BA 40, the medial temporal gyrus and the medial frontal gyrus. These results are similar to the estimated generators observed in recent experiments on the same motion platform using short translational accelerations (Ertl et al 2017(Ertl et al , 2020 as well as data acquired by other neuroimaging modalities (Zu Eulenburg et al 2012;Lopez et al 2012). A region of interest analysis of our data revealed that only the signal in a sub-region of BA 40 was modulated by the task.…”

Section: Discussionsupporting

confidence: 91%

“…2b). The first components showed the P1/N1/P2 pattern as described in previous vestibular ERP studies (Todd et al 2016;Ertl et al 2017Ertl et al , 2020. Contrary to our previous experiments, the ERPs elicited by the used stimulation in the current study were, due to different vestibular thresholds, not phase-locked.…”

Section: Event-related Potentials (Erp)supporting

confidence: 45%

“…The excellent temporal resolution of EEG enabled the identification of early, middle and long latency potentials and their association with particular brain structures. Additionally, initial attempts to analyze and interpret vestibular-evoked oscillation patterns have been made (Bertora and Bergmann 1995;Gale et al 2016;Ertl et al 2017Ertl et al , 2020.…”

Section: Introductionmentioning

confidence: 99%

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The role of delta and theta oscillations during ego-motion in healthy adult volunteers

et al. 2021

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The successful cortical processing of multisensory input typically requires the integration of data represented in different reference systems to perform many fundamental tasks, such as bipedal locomotion. Animal studies have provided insights into the integration processes performed by the neocortex and have identified region specific tuning curves for different reference frames during ego-motion. Yet, there remains almost no data on this topic in humans.In this study, an experiment originally performed in animal research with the aim to identify brain regions modulated by the position of the head and eyes relative to a translational ego-motion was adapted for humans. Subjects sitting on a motion platform were accelerated along a translational pathway with either eyes and head aligned or a 20° yaw-plane offset relative to the motion direction while EEG was recorded.Using a distributed source localization approach, it was found that activity in area PFm, a part of Brodmann area 40, was modulated by the congruency of translational motion direction, eye, and head position. In addition, an asymmetry between the hemispheres in the opercular-insular region was observed during the cortical processing of the vestibular input. A frequency specific analysis revealed that low-frequency oscillations in the delta- and theta-band are modulated by vestibular stimulation. Source-localization estimated that the observed low-frequency oscillations are generated by vestibular core-regions, such as the parieto-opercular region and frontal areas like the mid-orbital gyrus and the medial frontal gyrus.

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Section: Discussionsupporting

confidence: 91%

Section: Event-related Potentials (Erp)supporting

confidence: 45%

Section: Introductionmentioning

confidence: 99%

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The role of delta and theta oscillations during ego-motion in healthy adult volunteers

et al. 2021

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“…This is consistent with fMRI studies showing activity in the cingulate cortex following CVS ( 75 , 164 , 165 ) and GVS ( 89 ). Other studies reported positive individual components around 40 ms following whole-body rotations [( 163 ); 38.9 ms] and translations [( 33 , 166 , 167 ); p38.2 ms under parietal electrodes]. More recently, IAS on the left mastoid was also found to evoke n25, p40, and n53 components under Bz, an electrode placed over the cerebellum, two rows below Iz at the midline [( 150 ); following a nomenclature proposed by Heine et al ( 168 )].…”

Section: Middle Latency Vestibular-evoked Potentialsmentioning

confidence: 99%

“…Whole-body translation evoked the n80, a negative component with a peak latency of 80 ms [( 33 , 166 , 167 ); Figure 5B ]. The n80 was most prominent under frontal electrodes, but a weaker occipital positivity was also observed with the same latency.…”

Section: Late Latency Vestibular-evoked Potentialsmentioning

confidence: 99%

Vestibular-Evoked Cerebral Potentials

2021

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The human vestibular cortex has mostly been approached using functional magnetic resonance imaging and positron emission tomography combined with artificial stimulation of the vestibular receptors or nerve. Few studies have used electroencephalography and benefited from its high temporal resolution to describe the spatiotemporal dynamics of vestibular information processing from the first milliseconds following vestibular stimulation. Evoked potentials (EPs) are largely used to describe neural processing of other sensory signals, but they remain poorly developed and standardized in vestibular neuroscience and neuro-otology. Yet, vestibular EPs of brainstem, cerebellar, and cortical origin have been reported as early as the 1960s. This review article summarizes and compares results from studies that have used a large range of vestibular stimulation, including natural vestibular stimulation on rotating chairs and motion platforms, as well as artificial vestibular stimulation (e.g., sounds, impulsive acceleration stimulation, galvanic stimulation). These studies identified vestibular EPs with short latency (<20 ms), middle latency (from 20 to 50 ms), and late latency (>50 ms). Analysis of the generators (source analysis) of these responses offers new insights into the neuroimaging of the vestibular system. Generators were consistently found in the parieto-insular and temporo-parietal junction—the core of the vestibular cortex—as well as in the prefrontal and frontal areas, superior parietal, and temporal areas. We discuss the relevance of vestibular EPs for basic research and clinical neuroscience and highlight their limitations.

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