Spectral-domain Optical Coherence Tomography Retinal and Choroidal Thickness Metric Repeatability in Age-related Macular Degeneration

Hanumunthadu, Daren; Ilginis, Tomas; Restori, Marie; Sagoo, Mandeep S.; Tufail, Adnan; Balaggan, Kamaljit S.; Patel, Praveen J

doi:10.1016/j.ajo.2016.03.052

Cited by 16 publications

(15 citation statements)

References 29 publications

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“…We hypothesize that the accuracy of CT measurements is more dependent on anatomic factors that may affect light penetration and signal strength at the posterior boundary of the choroid, than the biological process underlying the retinal exudation. Prior reports in eyes with neovascular AMD demonstrated intergrader CR values of 30–36 μm, which were comparable to other reports from normal eyes, 15,22,26 but lower compared to our prior study. Those results may have been confounded by eyes with a thinner choroid, which tends to occur in advanced AMD.…”

Section: Discussionsupporting

confidence: 89%

Macular Fluid Reduces Reproducibility of Choroidal Thickness Measurements on Enhanced Depth Optical Coherence Tomography

Wong

Vuong

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et al. 2017

American Journal of Ophthalmology

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Purpose To determine if different types of retinal fluid in the central macula affect the reproducibility of choroidal thickness (CT) measurements on enhanced depth imaging optical coherence tomography (EDI-OCT) Design retrospective, reliability analysis Methods EDI-OCT images were obtained and the choroidal-scleral junction was analyzed through semi-automated segmentation. CT was measured at the fovea and averaged across the central 3 mm horizontal segment. Demographic data, central macular thickness and type of fluid present were recorded. Intragrader and intergrader repeatability were assessed using the intraclass correlation coefficient (ICC) and coefficient of repeatability (CR). Results Of 124 eyes analyzed, 60 (48.4%) had diabetic macular edema, 32 (25.8%) had neovascular age-related macular degeneration, and 32 (25.8%) had other causes of fluid. Intergrader ICC (CR) were 0.95 (74.1 μm) and 0.96 (63.9 μm) for subfoveal and average CT, respectively. CR were similar across various causes of retinal fluid, but were worst for subretinal fluid compared to intraretinal or sub-retinal pigment epithelial fluid. CR also worsened with increasing choroidal thickness, but was not affected by retinal thickness. Intragrader repeatability was generally greater than intergrader values, and followed the same trend. Conclusions The presence of macular fluid reduces CT measurement reproducibility, particularly in eyes with subretinal fluid and greater choroidal thickness. A difference of 74.1 μm in subfoveal CT or 63.9 μm in average CT may be necessary to detect true clinical change in eyes with macular fluid.

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Section: Discussionsupporting

confidence: 89%

Macular Fluid Reduces Reproducibility of Choroidal Thickness Measurements on Enhanced Depth Optical Coherence Tomography

Wong

Vuong

Cunefare

et al. 2017

American Journal of Ophthalmology

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“…Previous studies have reported a higher level of reproducibility of patients when measured manually in healthy patients, including a study at our institution, which suggested a CR of 34 μm using enhanced depth imaging SD-OCT 27. We note that our previous study investigating SD-OCT (Spectralis, Heidelberg, Heidelberg Engineering) repeatability in AMD reported a CR of 30.6 and 34.7 μm for retinal and choroidal thickness repeatability, respectively 28. This suggests that SD-OCT may be more repeatable than macular thickness measurements taken in eyes with nAMD using SS-OCT.…”

Section: Discussionmentioning

confidence: 52%

Repeatability of swept-source optical coherence tomography retinal and choroidal thickness measurements in neovascular age-related macular degeneration

et al. 2016

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“…This study showed that using a written graph-theory-based software to segment EDI-OCT images produced a repeatability of choroidal thickness measurement of approximately 7 and 10 µm in children wearing SV spectacles and ortho-k lenses, respectively. Previous studies30 34 35 38 have segmented the choroidal thickness manually, while others38 59 have applied algorithm-based software for automatic segmentation and measurement of choroidal thickness. While the CR estimate is useful in setting an assessment tool of minimal detectable change,60 61 our results of a CR of approximately 10 µm indicated that automatic measurement of choroidal thickness was more repeatable than other studies solely using manual segmentation (CR of about 35 µm) 30 34.…”

Section: Discussionmentioning

confidence: 99%

“…In most published studies,28–33 choroidal thickness was determined manually due to the unavailability of built-in functions. It has been shown that the coefficient of repeatability (CR) of the interimage repeatability (in which images were captured consecutively at the same visit) was about 35 µm 30 34. With the help of image processing and analysis software, Boonarpha et al 35 measured choroidal thickness using manually marked boundaries and showed an overall CR of 54 µm in choroids of different contours and shapes.…”

Section: Introductionmentioning

confidence: 99%

Repeatability of choroidal thickness measurements with Spectralis OCT images

et al. 2019

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ObjectiveTo investigate the repeatability of choroidal thickness measurements determined from enhanced depth imaging optical coherence tomography (EDI-OCT) images of eyes after wearing single-vision spectacles (SV) and orthokeratology (ortho-k) lenses.Methods and analysisTwo EDI-OCT images of 40 children (SV: 20, ortho-k: 20) taken at a single visit were analysed twice. Subjects in the ortho-k group had been wearing ortho-k for 1–4 weeks. The choroidal thickness was determined from each image using a graph theory-based software and, where appropriate, manual correction of choroidal boundaries was undertaken by an experienced examiner.ResultsThe mean (±SD) choroidal thickness was 227.3±42.2 µm for the SV subjects and 251.1±54.4 µm for the ortho-k subjects. The interimage differences in choroidal thickness were −0.99±3.54 and −1.14±5.03 µm for the SV and ortho-k subjects, respectively, and the limits of agreement were +5.96 to −7.93 and +8.72 to −11.00 µm, respectively.ConclusionThe coefficients of repeatability of choroidal thickness measurements from two EDI-OCT images taken at a single visit were 7.08 µm (SV) and 10.06 µm (ortho-k), suggesting that a change in choroidal thickness of less than 10 µm may not indicate a real change resulting from ortho-k lens wear.

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Spectral-domain Optical Coherence Tomography Retinal and Choroidal Thickness Metric Repeatability in Age-related Macular Degeneration

Cited by 16 publications

References 29 publications

Macular Fluid Reduces Reproducibility of Choroidal Thickness Measurements on Enhanced Depth Optical Coherence Tomography

Macular Fluid Reduces Reproducibility of Choroidal Thickness Measurements on Enhanced Depth Optical Coherence Tomography

Repeatability of swept-source optical coherence tomography retinal and choroidal thickness measurements in neovascular age-related macular degeneration

Repeatability of choroidal thickness measurements with Spectralis OCT images

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