Spectral-domain Optical Coherence Tomography Measurement of Macular Volume for Diagnosing Glaucoma

Abstract

Selective measurement of the GCC layer by SD-OCT improves diagnostic performance of the macular structural analysis for glaucoma diagnosis.

Diagnostic accuracy of nerve fibre layer, macular thickness and optic disc measurements made with the RTVue-100 optical coherence tomograph to detect glaucoma

“…6,11,14,15,[17][18][19][20][21] In such investigations, for the best performing RNFLT and GCC parameters of the RTVue-100 OCT, the area under the receiver operating characteristic curve varied between 0.900 and 0.971. [17][18][19][20][21] Other authors using other Fourier-domain OCT systems reported on similar values. 6,15 These results suggest that under pre-defined circumstances the diagnostic accuracy of Fourier-domain OCT technology is somewhat higher than that of time-domain OCT technology.…”

“…OCT instruments employing the Fourier-domain technology have significantly higher resolution and scan speed, improved image segmentation and better measurement reproducibility compared with the timeFdomain OCT. [1][2][3][4][5][6] Though the technology is new, information on the diagnostic accuracy of the different Fourier-domain OCT instruments to detect glaucoma of different severity, is increasing. 5,6,[13][14][15][16][17][18][19][20][21] The RTVue-100 OCT (Optovue Inc., Fremont, CA, USA) is one of the new commercially available Fourier-domain OCT instruments. [1][2][3][4][17][18][19][20][21] Its axial resolution is approximately 5 mm and the scan speed is 26 000 A-scans per second.…”

“…5,6,[13][14][15][16][17][18][19][20][21] The RTVue-100 OCT (Optovue Inc., Fremont, CA, USA) is one of the new commercially available Fourier-domain OCT instruments. [1][2][3][4][17][18][19][20][21] Its axial resolution is approximately 5 mm and the scan speed is 26 000 A-scans per second. Thus the speed is 65 times higher than that of the Stratus OCT system, and the resolution is about twice as good as such time-domain OCT instruments.…”

Retinal nerve fiber layer and macular inner retina measurements by spectral domain optical coherence tomograph in Indian eyes with early glaucoma

“…SD-OCT by its ability to measure individual layers of the retina may capture these changes in the macula, and a few recent studies with SD-OCT, in fact, have shown that the macular inner retinal (MIR) thickness measurements, which consists of the innermost 3 layers of the retina, namely the nerve fiber layer, ganglion cell layer, and the inner plexiform layer, were as good as the RNFL measurements in detecting glaucoma. [10][11][12][13][14] These studies, however, included glaucoma patients with all severities of visual field damage that might have biased the results, as the estimates of diagnostic accuracy are known to improve with the severity of disease. [15][16][17] In clinical practice, the challenge is to diagnose glaucoma in early stages and there is limited literature on the diagnostic ability of SD-OCT in early glaucoma.…”

Diagnostic utility of RNFL Thickness and Macular GCC Thickness in Primary Open Angle Glaucoma using Spectral Domain Optical Coherence Tomography in South Indian patients

“…In other studies, HL Rao et al, [4] in early POAG eyes and Seong et al, [13] in normal tension glaucoma eyes with early visual field damage, found comparable diagnostic abilities between average RNFL and macular parameters using the Fourier domain RTVue OCT. In few studies, Mori et al [14] , HL Rao et al [4] reported selective measurements of macula inner retinal (MIR) volume by Fourier domain OCT to have better diagnostic performance among macular parameters in early diagnosis of glaucoma. The inconsistencies in the diagnostic capabilities of macular parameters in various studies using SD OCT may be due to the fact that SD OCT can measure the GCC thickness in the centre of macular area (7×6 mm2) only, thus excluding the glaucomatous damage outside this region which might be affected in early glaucoma.…”