Spectral-Domain Optical Coherence Tomography in Irvine–gass Syndrome

Minnella, Angelo Maria; Savastano, Maria Cristina; Zinzanella, G.; Mazzone, Giancarlo; Federici, Matteo; Gari, Mariangela; Falsini, Benedetto; Balestrazzi, E.

doi:10.1097/iae.0b013e31821e2225

Cited by 14 publications

(14 citation statements)

References 31 publications

(32 reference statements)

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“…Unfortunately, these patients were excluded from the analysis and the serial macular thickness was not given. Minnella et al gave OCT details of 15 patients with Irvine-Gass syndrome [12]. However they did not mention whether these patients had intraoperative complication during surgery.…”

Section: Discussionmentioning

confidence: 99%

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Spectral-domain optical coherence tomography evaluation of postoperative cystoid macular oedema following phacoemulsification with intraoperative complication

et al. 2014

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BackgroundTo report the rate of cystoid macular oedema (CMO) as detected by spectral-domain optical coherence tomography (SD-OCT) after intraoperative complication during phacoemulsification. The secondary objectives include comparing mean macular thickness and best-corrected visual acuity (BCVA) between those who developed postoperative CMO against those who did not.MethodsThis is a prospective cohort study conducted in a tertiary hospital between July 2009 and June 2010. Serial SD-OCT and BCVA were performed at baseline, 1 week, 6 weeks and 16 weeks postoperatively.ResultsSingle eyes from 47 subjects were analyzed; of these 16 (34%) eyes developed CMO. In the CMO group, mean macular thickness (±SD) increased sharply by 56 μm from 273 ± 24 μm at baseline to 329 ± 31 μm at 16 weeks; whereas in the non-CMO group, macular thickness showed a slight increase of 14 μm from 259 ± 21 μm to 272 ± 20 μm. In the CMO group, mean BCVA (in logarithm of minimum angle of resolution) improved modestly from 0.92 ± 0.66 to 0.66 ± 0.41 at week 16; while in the non-CMO group, mean BCVA improved markedly from 0.98 ± 0.59 to 0.21 ± 0.13. The two groups differed significantly in mean macular thickness (p < 0.001) and mean BCVA (p < 0.001) at 16 weeks.ConclusionAs detection rate of CMO is high, postoperative OCT monitoring for patients with intraoperative complications allows earlier diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

“…This was defined as the presence of hyporeflective intraretinal cystoid changes noted on SD-OCT which was not present preoperatively [12]. It was graded by a single consultant ophthalmologist (VS) who was masked from the patient’s intraoperative complication, visual acuities and treatment approach.…”

Section: Methodsmentioning

confidence: 99%

Spectral-domain optical coherence tomography evaluation of postoperative cystoid macular oedema following phacoemulsification with intraoperative complication

et al. 2014

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“…8,42 The mechanism in Irvine-Gass is thought to involve prostaglandins, whereas uvCME seems to involve T-cell cytokines and CD4 + T-cell immunomodulation. 8,42 The mechanism in Irvine-Gass is thought to involve prostaglandins, whereas uvCME seems to involve T-cell cytokines and CD4 + T-cell immunomodulation.…”

Section: Macular Edema Patternmentioning

confidence: 99%

“…Macular edema in RVO is initially based on stasis, increased hydrostatic pressure, and hypoxia and only secondarily based on increased vascular permeability and cytokine release. 8,42 Longer disease duration in uvCME compared with Irvine-Gass eventually leads to ganglion cell loss, so RNFL atrophy may be another explanation for the difference found between the two diseases. Ischemia and intraretinal hemorrhage may further increase respective RNFL thickness.…”

Section: Retinal Layer Thicknessmentioning

confidence: 99%

“…2,3 A major pathway of ME development is a breakdown of the inner and/or outer blood-retina barriers with increased vascular permeability. 5,8 In retinal vein occlusion (RVO), cytokine release, hypoxia, increased hydrostatic pressure, and vascular stasis may contribute to ME formation. 1,2,[4][5][6][7] In inflammatory MEs such as uveitis and Irvine-Gass, ME is predominantly based on a release of proinflammatory mediators.…”

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Differential Diagnosis of Macular Edema of Different Pathophysiologic Origins by Spectral Domain Optical Coherence Tomography

Munk

Sacu

Huf

et al. 2014

Retina

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Recurrent Vitreomacular Traction in a Patient Treated with Ocriplasmin: A Case Report

Katsanos

Gorgoli²,

Asproudis

et al. 2020

Ophthalmol Ther

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Introduction: To describe a case of recurrent vitreomacular traction and macular edema that appeared both before and after the intravitreal injection of ocriplasmin. Case Report: An 82-year-old monocular man presented with metamorphopsia and reduced vision of 1-week duration. The patient's general medical history was unremarkable. His ophthalmic history was significant for severe ocular trauma in the right eye in childhood that caused phthisis. The left eye had undergone uncomplicated phacoemulsification 3 months earlier and the 1-month postoperative best corrected visual acuity (BCVA) was logarithmic mean angle of resolution (logMAR) 0.0. There was no history of other ocular conditions. At presentation, BCVA was logMAR 0.2 and optical coherence tomography (OCT) revealed the presence of cystoid macular edema caused by vitreomacular traction (VMT). The patient was scheduled for intravitreal ocriplasmin injection. Prior to treatment, the vision improved spontaneously to logMAR 0.1, and no VMT could be detected with spectral domain (SD)-OCT. The ocriplasmin injection was deferred but 3 weeks later the patient presented again with metamorphopsia, while VMT was again evident on SD-OCT. Ocriplasmin was injected and 1 month later the BCVA reached logMAR 0.1 without VMT. However, at 2 months post injection the VMT reappeared and a conservative approach with observation and topical nepafenac administration was decided. At the 3-month post-injection visit there was no VMT. More than 3 years after the ocriplasmin injection there is still no evidence of VMT, the patient is free of metamorphopsia, and his BCVA is log-MAR 0.0. Conclusion: Separation of consecutive layers of the vitreous cortex (vitreoschisis) may account for recurrent VMT.

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Spectral-Domain Optical Coherence Tomography in Irvine–gass Syndrome

Abstract: Spectral-domain optical coherence tomography detects retinal findings, including photoreceptor inner segment/outer segment junction abnormalities that are correlated with visual acuity changes in treated patients with Irvine-Gass syndrome.

Cited by 14 publications

References 31 publications

Spectral-domain optical coherence tomography evaluation of postoperative cystoid macular oedema following phacoemulsification with intraoperative complication

Spectral-domain optical coherence tomography evaluation of postoperative cystoid macular oedema following phacoemulsification with intraoperative complication

Differential Diagnosis of Macular Edema of Different Pathophysiologic Origins by Spectral Domain Optical Coherence Tomography

Recurrent Vitreomacular Traction in a Patient Treated with Ocriplasmin: A Case Report

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