Spectral domain-optical coherence tomography analysis of choroidal osteoma

Abstract

This study revealed that SD-OCT provided deeper and higher resolution images of choroidal osteoma when compared with previous studies using time domain-OCT. These findings offer new insights into the pathophysiology and diagnosis of choroidal osteoma.

Seven-year Follow-up of Clinical Course of Choroidal Osteoma: A Case Report

“…In our case visual acuity was good as the fovea was spared of decalcification as per documentation on the OCT. 9 Aurélien Freton et al noted isoreflectivity of osteoma in SD OCT in 7 cases, hyper-reflectivity in two and hyporeflectivity in two of their 11 cases. 11 In our case we noted hyper-reflectivity of the osteoma with scattered deposits all over the space between RPE and sensory retina. Through the FA, Stratus and SD OCT, we documented the course of the disease treated with bevacizumab.…”

Bone Remodeling in Choroidal Osteoma Monitored by Fundus Photography and Spectral-Domain Optical Coherence Tomography

“…This is supported by the histopathological findings of osteocytes, osteoclasts and osteoblasts by Williams et al [14] in enucleated eyes with choroidal osteoma. SD-OCT findings of cavernous or sponge-like features with variable internal reflectivity [9,10] corroborate the presence of bony trabeculae and are suggestive of the various stages of the bone formation process occurring in choroidal osteomas. A common SD-OCT finding in choroidal osteoma is tumor elevation into the vitreous cavity [10,11,12,15].…”

“…Diagnosis, by convention, is made by clinical examination and fundus angiography, and confirmed by the presence of choroidal calcification on ultrasonography or other modes of imaging such as computed tomography. Spectral-domain optical coherence tomography (SD-OCT) has provided high-resolution cross-sectional images of the tumor and overlying retina [9,10,11], as well as a 3-dimensional view of the tumor [12]. Remodeling of the tumor has been suggested to explain the varying degrees of tumor reflectivity found on SD-OCT [10].…”

Fundus Autofluorescence Findings of Choroidal Osteoma

“…Fundus autofluorescence decreased drastically in funduscopically white areas of total decalcification that were associated with choriocapillaris and RPE atrophy on SD-OCT. In our series, decreased FAF because of decalcification and increased FAF because of lipofuscin accumulation were observed in the center of osteoma lesions, where the thickest portion of the tumor compressed the choriocapillaris on SD-OCT. 14,15 The likelihood and degree of FAF alterations overlying osteoma lesions did not directly correlate with patient age, although increased chronicity of choroidal osteoma lesions has been associated with a greater likelihood of growth, decalcification, and CNV. 5 The length of follow-up for patients in our series was not sufficient to evaluate this.…”