Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging

Joo, Chulmin; Akkin, Taner; Cense, Barry; Park, Boris H.; Boer, Johannes F. de

doi:10.1364/ol.30.002131

Cited by 237 publications

(170 citation statements)

References 15 publications

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“…Measurements were acquired utilizing spectral-domain phase microscopy (SDPM), an interferometric technique used previously for dynamic nanoscale measurement in biological and non-biological materials 18,19) . Blocks were secured at their bases in a 3-axis positioning stage (Newport 460A series) with one cusp wall facing the SDPM sample beam.…”

Section: Spectral-domain Phase Microscopymentioning

confidence: 99%

Assessment of cuspal deflection and volumetric shrinkage of different bulk fill composites using non-contact phase microscopy and micro-computed tomography

et al. 2018

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The understanding of cuspal deflection and volumetric shrinkage of resin composites is necessary to assess and improve the placement techniques of resin-based materials. The aim of this study was to investigate the cuspal deflection and its relationship with volumetric polymerization shrinkage of different bulk-fill resin composites. The investigation was conducted using non-contact phase microscopy and micro-computed tomography. Thirty custom-milled aluminum blocks were fabricated for microscopy analysis and thirty-six tooth models with standardized Class I cavities were used for micro-computed tomography analysis. Results showed that high-viscosity composites present higher cuspal deflection compared to bulk-fill composites. The filler loading of resin composites seems to have an effect on cusp deflection, since the higher the filler content percentage, the higher the cusp deflection. On the other hand, it seems to have an opposite effect on volumetric shrinkage, since higher filler loadings produced lower volumetric shrinkage percentages.

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Section: Spectral-domain Phase Microscopymentioning

confidence: 99%

Assessment of cuspal deflection and volumetric shrinkage of different bulk fill composites using non-contact phase microscopy and micro-computed tomography

et al. 2018

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“…The development of FD-OCT enabled the application of common path interferometers, where a partial reflection in the probing beam path is used as reference [94,99]. Typically, a cover slip in front of the sample serves as reference mirror.…”

Section: Phase Sensitive Octmentioning

confidence: 99%

Optical coherence tomography—current technology and applications in clinical and biomedical research

et al. 2011

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Optical coherence tomography (OCT) is a non-invasive imaging technique providing real-time twoand three-dimensional images of scattering samples with micrometer resolution. Mapping the local reflectivity, OCT visualizes the morphology of the sample. In addition, functional properties such as birefringence, motion or the distribution of certain substances can be detected with high spatial resolution. The main field of application is bio-medical imaging and diagnostics. In ophthalmology, OCT is accepted as a clinical standard for diagnosing and monitoring treatment of a number of retinal diseases, and OCT is becoming an important instrument for clinical cardiology. New applications are emerging in various medical fields, e. g. early-stage cancer detection, surgical guidance, and early diagnosis of musculoskeletal diseases. OCT has also proven its value as a tool for developmental biology. The number of companies involved in manufacturing OCT systems has increased substantially during the last years-especially due to its success in opthalmology-and this technology can be expected to continue to spread into various fields of application.

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“…While a number of QPI approaches for visualizing neurons and brain tissues have been introduced, e.g., digital holographic microscopy [10,11], optical coherence phase microscopy [12], diffraction phase microscopy (DPM) [13,14], spatial light interference microscopy [15,16], they all utilize interferometry as the underlying operating principle. From the interferogram, the alteration in optical pathlength due to tissue is obtained with nanoscale sensitivity.…”

Section: Introductionmentioning

confidence: 99%

“…This level of sensitivity is difficult to achieve with any other method. However, QPI has been limited to visualizing cultured neurons and very thin histological section (4-5 microns) [10][11][12][13][14][15][16]. The reason is that the light scattering prevents imaging thick tissues.…”

Section: Introductionmentioning

confidence: 99%

Measurement of multispectral scattering properties in mouse brain tissue

Min

Ban

Wang

et al. 2017

Biomed. Opt. Express

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Abstract:We present the scattering properties of mouse brain using multispectral diffraction phase microscopy. Typical diffraction phase microscopy was incorporated with the broadband light source which offers the measurement of the scattering coefficient and anisotropy in the spectral range of 550-900 nm. The regional analysis was performed for both the myeloarchitecture and cytoarchitecture of the brain tissue. Our results clearly evaluate the multispectral scattering properties in the olfactory bulb and corpus callosum. The scattering coefficient measured in the corpus callosum is about four times higher than in the olfactory bulb. It also indicates that it is feasible to realize the quantitative phase microscope in near infrared region for thick brain tissue imaging.

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Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging

Cited by 237 publications

References 15 publications

Assessment of cuspal deflection and volumetric shrinkage of different bulk fill composites using non-contact phase microscopy and micro-computed tomography

Assessment of cuspal deflection and volumetric shrinkage of different bulk fill composites using non-contact phase microscopy and micro-computed tomography

Optical coherence tomography—current technology and applications in clinical and biomedical research

Measurement of multispectral scattering properties in mouse brain tissue

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