Spectral-domain OCT with dual illumination and interlaced detection for simultaneous anterior segment and retina imaging

Jeong, Hyun Chul; Lee, Sang-Won; Kim, Beop Min

doi:10.1364/oe.20.019148

Cited by 24 publications

(19 citation statements)

References 38 publications

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“…An approach with two spectrometers or two scanning channels in the OCT system has been demonstrated to be useful in imaging the anterior segment and the retina. 12, 14 Ruggeri et al 15 demonstrated that the full eye could be imaged with a switchable reference arm. These OCT approaches could be used to obtain axial biometry of the entire eye, but only a portion of the eye was imaged (anterior segment and the retina).…”

Section: Discussionmentioning

confidence: 99%

Axial Biometry of the Entire Eye Using Ultra-Long Scan Depth Optical Coherence Tomography

Zhong

Shao²,

Tao³

et al. 2014

American Journal of Ophthalmology

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Purpose To assess the repeatability of axial biometry of the entire eye using ultra-long scan depth optical coherence tomography (ultra-long scan depth-OCT) and to investigate the agreement with IOLMaster. Design Prospective, observational case series. Methods There were 37 adult subjects enrolled in Group 1 and 12 adult subjects in Group 2. Using ultra-long scan depth-OCT, the left eyes of these groups were measured in two separate sessions. The images were processed by a manual method and custom-developed automatic software. A model eye was imaged for verification. The subjects of Group 2 were imaged using ultra-long scan depth-OCT and using the IOLMaster for axial length measurement comparison. Results All measured parameters of the model eye matched the geometric parameters. In Group 1, there were no significant differences in all measured parameters using automatic and manual segmentation methods (paired t-test, P > .05). The CoR% of segments ranged from 0.3% to 3.9%. The corresponding inter-class correlation coefficients (ICC) ranged from 0.946 to 0.999. The correlation between the results using automatic and manual segmentation methods appeared strong (R2 = 0.999, P < .05). In Group 2, the axial length of the eye measured by the IOL Master matched the results obtained by ultra-long scan depth-OCT with the automatic method (R12 = 0.987, P < 0.05) and the manual method (R22 = 0.988, P < .05). Conclusions Automatic axial biometry using ultra-long scan depth-OCT successfully measured each segment of the entire eye with good repeatability. With further development of automatic segmentation, ultra-long scan depth-OCT appeared to be a promising tool in the axial biometry of the entire eye.

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Section: Discussionmentioning

confidence: 99%

Axial Biometry of the Entire Eye Using Ultra-Long Scan Depth Optical Coherence Tomography

Zhong

Shao²,

Tao³

et al. 2014

American Journal of Ophthalmology

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“…Although our combined system is able to image the anterior segment including the ciliary muscle, the need to modify the reference arms for compensating sensitivity drop-off and implementation of the shutter may complicate the imaging approach. Further improvement with one system and alterative scanning channels [56] using the wavelength of 1 µm [18] may simplify the approach. Imaging the muscle apex position and width is important in studying the accommodative response.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous real-time imaging of the ocular anterior segment including the ciliary muscle during accommodation

Shao

Tao

Jiang³

et al. 2013

Biomed. Opt. Express

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We demonstrated a novel approach of imaging the anterior segment including the ciliary muscle using combined and synchronized two spectral domain optical coherence tomography devices (SD-OCT). In one SD-OCT, a Complementary Metal-Oxide-Semiconductor Transistor (CMOS) camera and an alternating reference arm was used to image the anterior segment from the cornea to the lens. Another SD-OCT for imaging the ciliary muscle was equipped with a light source with a center wavelength of 1,310 nm and a bandwidth of 75 nm. Repeated measurements were performed under relaxed and 4.00 D accommodative stimulus states in six eyes from 6 subjects. We also imaged dynamic changes in the anterior segment in one eye during accommodation. The biometry of the anterior segment and the ciliary muscle was obtained. The combined system appeared to be capable to simultaneously real-time image the biometry of the anterior segment, including the ciliary muscle, in vivo during accommodation.

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“…The cornea is not clear due to the 50% attenuation of the reflected light. A single spectrometer with two illumination sources and interlaced detection has been set up to acquire the anterior segment and retinal tomograms simultaneously [3]. The entire lens was not imaged in that system due to the scan depth being nearly 6.0 mm after the complex artifact removal algorithm was employed.…”

Section: Discussionmentioning

confidence: 99%

“…Because we used a 4096 pixel camera instead of one with 2048 pixels, the imaging depth was increased to more than 12.0 mm, which is long enough to image the entire anterior segment. When imaging the cornea and retina simultaneously with dual-channel SD-OCT systems [3,13], the relative motion between the two regions can be estimated. The disadvantage of our system is the retina obtained from the current study was a small plane line due to the telecentric scanning when measuring the axial length.…”

Section: Discussionmentioning

confidence: 99%

Versatile optical coherence tomography for imaging the human eye

Tao

Shao

Zhong

et al. 2013

Biomed. Opt. Express

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We demonstrated the feasibility of a CMOS-based spectral domain OCT (SD-OCT) for versatile ophthalmic applications of imaging the corneal epithelium, limbus, ocular surface, contact lens, crystalline lens, retina, and full eye in vivo. The system was based on a single spectrometer and an alternating reference arm with four mirrors. A galvanometer scanner was used to switch the reference beam among the four mirrors, depending on the imaging application. An axial resolution of 7.7 μm in air, a scan depth of up to 37.7 mm in air, and a scan speed of up to 70,000 A-lines per second were achieved. The approach has the capability to provide high-resolution imaging of the corneal epithelium, contact lens, ocular surface, and tear meniscus. Using two reference mirrors, the zero delay lines were alternatively placed on the front cornea or on the back lens. The entire ocular anterior segment was imaged by registering and overlapping the two images. The full eye through the pupil was measured when the reference arm was switched among the four reference mirrors. After mounting a 60 D lens in the sample arm, this SD-OCT was used to image the retina, including the macula and optical nerve head. This system demonstrates versatility and simplicity for multi-purpose ophthalmic applications.

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Spectral-domain OCT with dual illumination and interlaced detection for simultaneous anterior segment and retina imaging

Cited by 24 publications

References 38 publications

Axial Biometry of the Entire Eye Using Ultra-Long Scan Depth Optical Coherence Tomography

Axial Biometry of the Entire Eye Using Ultra-Long Scan Depth Optical Coherence Tomography

Simultaneous real-time imaging of the ocular anterior segment including the ciliary muscle during accommodation

Versatile optical coherence tomography for imaging the human eye

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