Spectral Data Analyses and Structure Elucidation of Hypoglycemic Drug Glipizide

Xin, Ming; Qi, Zheng-chun; Lian, Hong-zhen; Wang, Shaokun

doi:10.1080/10739140802234956

Cited by 1 publication

(2 citation statements)

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“…1 H-NMR analyses of GLP in CDCl3 and d6-DMSO were performed, and signals of the protons of GLP in d6-DMSO were found to be in agreement with the literature (Ming et al, 2008). The protons of GLP taken 1 H-NMR in CDCl3 were accordingly assigned based on their chemical environments.…”

Section: Nmr Analysessupporting

confidence: 63%

“…GLP displays hypoglycemic (Pahwa et al, 2010), anticancer (Qi et al, 2014), and radical scavenging activities (by theoretical approach) (Hussan et al, 2022), and controlled release behaviors (Emami et al, 2014). Besides, a wide range of spectroscopic analyses of GLP has been performed in the literature (Ming et al, 2008;Adhikari et al, 2012;Prasad et al, 2013;Prakash & Iqbal, 2015;Ganesh et al, 2016;Jena et al, 2017;Ambadekar & Keni, 2018;Anwer et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Chloride Anion Binding Properties of Glipizide Drug

MERT

2023

Gazi University Journal of Science Part A: Engineering and Innovation

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This study addresses the anion binding property of Glipizide (GLP), an oral antidiabetic a second-generation drug member of the sulphonylurea (SU) family. GLP effectively interacts with Cl- anion according to 1H-NMR spectroscopic titrations of successive tetrabutylammonium chloride (TBACl) in deuterated chloroform (CDCl3) and dimethyl sulfoxide (d6-DMSO). Upon the addition of TBACl, the change in chemical shift was observed for both N-H protons of SU in CDCl3, whereas it causes a difference in the shift of only one of N-H proton in SU in d6-DMSO. In addition, the data obtained from 1H-NMR spectroscopic titrations was analyzed by DynaFit program to calculate the binding constant (Ka) value between GLP and Cl- anion. It was found that GLP binds Cl- anion in CDCl3 with higher affinity (Ka=77.37 M-1, Fitplot for N-Hh proton at δ=6.47 ppm) than in d6-DMSO (Ka=38.53 M-1, Fitplot for N-Hh proton at δ=6.32 ppm).

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Section: Nmr Analysessupporting

confidence: 63%