Spectral characterization of the bioactive principles and antibacterial properties of cold methanolic extract of Olea europaea from the Hail region of Saudi Arabia

Syed, Rahamat Unissa; Moni, Sivakumar Sivagurunathan; Alfaisal, Raghad Huraid; Alrashidi, Rawan Hamdan; Alrashidi, Nouf Fahad; Wadeed, Khadijah Mansour; Alshammary, Fayha Nafea; Habib, Alshammari Majd; Alharbi, Fai Mutaz; Rehman, Zia ur; Alam, Md Shamsher; Basode, Vinod Kumar

doi:10.1016/j.arabjc.2022.104006

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…This compound is a strong antioxidant, anti-arrhythmia, and cardiovascular drug with a protective effect [ 60 ]. Based on the consulted literature, the pharmacological properties of some other identified major compounds, such as Ethyl 2-nonenoate, 2-(2-Hydroxy-2-phenylethyl)-3,5,6-trimethylpyrazine, 2-(3,4-Dimethoxyphenyl) ethanol and N-acetyltyramine have not been established [ 61 ]. However, in the list of identified minor compounds (Peak area <3.41%), some are known to have antiplasmodial properties, such as β-Sitosterol identified in F. stigmatoloba , which was reported to show a high activity against a chloroquine-sensitive (3D7) strain with an IC 50 value of 5.51 μM [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluating phytochemical constituents and in-vitro antiplasmodial and antioxidant activities of Fadogiella stigmatoloba, Hygrophylla auriculata, Hylodesmum repandum, and Porphyrostemma chevalieri extracts

Manya Mboni,

Faes,

Fraselle

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Evaluating phytochemical constituents and in-vitro antiplasmodial and antioxidant activities of Fadogiella stigmatoloba, Hygrophylla auriculata, Hylodesmum repandum, and Porphyrostemma chevalieri extracts

Manya Mboni,

Faes,

Fraselle

et al. 2023

Heliyon

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“…The possible inhibition of dihydropteroate synthase in the test organisms may suggest that ZPRE has bacteriostatic effect. Also, the antibacterial properties of hexadecanoic acid has been reported (Syed et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, antibacterial and antibiofilm activities of ethanol extract of Zapotecca portoricensis roots

2023

JoSVAS

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This study evaluated the phytochemical composition, antioxidant, antibacterial and antibiofilm activities of ethanol extract of Zapotecca portoricensis root. The extract was prepared via cold maceration method and gas chromatography-mass spectrometry (GC-MS) was used to determine the phytochemical composition of the extract. The antioxidant activity was evaluated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferric reducing antioxidant power (FRAP) procedures. The antibacterial and antibiofilm activities of the extract were evaluated against clinical isolates of Eschericia coli, Staphylococcus aureus and Salmonella typhi using agar well diffusion technique. The GC-MS analysis showed the presence of seven (7) bioactive compounds. The extract produced concentration dependent increase in the antioxidant values in both the DPPH and FRAP assay protocols. The extract produced concentration-dependent increase in the zone of inhibition against the tested organisms. At 62.5 mg/mL and below concentrations, the zones of inhibition of Z. portoricensis root extract against E. coli and S. aureus were significantly (p < 0.05) lower when compared with the zone of inhibition of Z. portoricensis root extract against S. typhi. The minimum inhibitory concentration (MIC) of Z. portoricensis root extract against E. coil, S. aureus and S. typhi were 31.25, 15.63 and 62.50 mg/mL concentration, respectively. The extract produced concentration-dependent increase in antibiofilm activity. At 7.5 mg/kg, the extract produced 28.87, 34.01 and 66.45% inhibition of biofilm production against S. typhi, E. coli and S. aureus, respectively. The extract possess antioxidant, antibacterial and antibiofilm activities which could be linked to the presence ethyl iso allocholate and hexadecanoic acid

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“…Briefly, Muller Hinton agar plates were prepared for conducting the antibacterial study [10]. Bacterial subcultures were prepared from the stock culture, and after 24 h of incubation, the culture was subjected to antibacterial studies.…”

Section: Determination Of Antibacterial Susceptibilitymentioning

confidence: 99%

Formulation and Evaluation of Amikacin Sulfate Loaded Dextran Nanoparticles against Human Pathogenic Bacteria

et al. 2023

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Amikacin sulfate-loaded dextran sulfate sodium nanoparticles were formulated, lyophilized (LADNP), and then analyzed. The LADNP had a −20.9 ± 8.35 mV zeta potential, PDI of 0.256, and % PDI of 67.7. The zeta average nano size of LADNP was 317.9 z. d.nm, while the dimension of an individual particle was 259.3 ± 73.52 nm, and nanoparticle conductivity in colloidal solution was 2.36 mS/cm. LADNP has distinct endothermic peaks at temperatures at 165.77 °C, according to differential scanning calorimetry (DSC). The thermogravimetric analysis (TGA) showed the weight loss of LADNP, which was observed as 95% at 210.78 °C. XRD investigation on LADNP exhibited distinct peaks at 2θ as 9.6°, 10.4°, 11.4°, 18.9°, 20.3°, 24.4°, 28.2°, 33.2°, 38.9°, and 40.4° confirming crystalline structure. The amikacin release kinetics from LADNP revealed zero order kinetics with a linear release showed zero order kinetics with 37% of drug release in 7 h and had an R2 value of 0.99. The antibacterial effect of LADNP showed broad-spectrum activity against tested human pathogenic bacteria. The preset study demonstrated that LADNP is a promising antibacterial agent.

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Spectral characterization of the bioactive principles and antibacterial properties of cold methanolic extract of Olea europaea from the Hail region of Saudi Arabia

Cited by 8 publications

References 28 publications

Evaluating phytochemical constituents and in-vitro antiplasmodial and antioxidant activities of Fadogiella stigmatoloba, Hygrophylla auriculata, Hylodesmum repandum, and Porphyrostemma chevalieri extracts

Evaluating phytochemical constituents and in-vitro antiplasmodial and antioxidant activities of Fadogiella stigmatoloba, Hygrophylla auriculata, Hylodesmum repandum, and Porphyrostemma chevalieri extracts

Antioxidant, antibacterial and antibiofilm activities of ethanol extract of Zapotecca portoricensis roots

Formulation and Evaluation of Amikacin Sulfate Loaded Dextran Nanoparticles against Human Pathogenic Bacteria

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