Spectral Characterization and Antibacterial Activities of Benzyloxybenzaldehydethiosemicarbazone, 3,4‐Dihydroxybenzaldehydeisonicotinoylhydrazone and their Transitional Metal Complexes

Abstract

The synthesis and spectral characterization of benzyloxy-benzaldehydethiosemicarbazone (BBTSC) and the study of antibacterial activity of ligands BBTSC, 3,4-dihydroxybenzaldehydeisoni- cotinoylhydrazone (3,4-DHBINH) and their transition metal complexes was studied. The composition of the metal complexes was also evaluated by using Job’s method, molar-ratio method and Asmus’ method. The antibacterial activities of BBTSC, 3,4-DHBINH and their complexesi.e., Cu(II)-BBTSC, Pd(II)-BBTSC, Cr(VI)- 3,4-DHBINH, Ti(IV)- 3,4-DHBINH and Pd(II)-3,4-DHBINH were studied against two gram positive bacteria and two gram negative bacteria. Antibacterial activities were evaluated by agar cup well method with the help of Luria Bertoni plates.

Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines

“…It has been shown that the α -(N)-heterocyclic carbaldehyde thiosemicarbazones act as chelating agents of the transition metals and some of them exhibit antitumor activity by inhibiting the biosynthesis of DNA, possibly by blocking the enzyme ribonucleotide diphosphate reductase [ 23 – 25 ]. On the other hand, the ligand 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) and its complexes [Zn(HmpETSC)Cl 2 ] and [Pd(mpETSC)Cl] exhibit antineoplastic activity against colon cancer human cell lines (HCT 116) with IC 50 values of 14.59, 16.96, and 20.65 μ M, respectively [ 26 ].…”

Physico-Chemical Optimization and Structure-Activity Relationship Studies of Aldehyde-Derived N-Acylhydrazones: Towards the Improvement of Moderate Metal Chelators as a Strategy Against Metal-Enhanced Aggregopathies

“…Another important band is seen at 3215 cm -1 , corresponding to the stretching of the N-H bond. Taken together, these data confirm the identity of the solid obtained, and these attributions are also in accordance to the literature (Suvarapu et al, 2011).…”

Synthesis and biological evaluation of novel tetranuclear cyclopalladated complex bearing thiosemicarbazone scaffold ligand: Interactions with double‐strand DNA, coronavirus, and molecular modeling studies

“…The anticancer activity of thiosemicarbazones stems from their chelating ability with transition metal ions by bonding through the sulfur and the azomethinic nitrogen atoms to inhibit the biosynthesis of DNA, possibly by blocking the enzyme ribonucleotide diphosphate reductase. [25,26] Notably, chelating ligands have been used to overcome this high lability, forming thermodynamically stable and kinetically inert cyclopalladated complexes. [27,28] Demertzi et al reported Pd(II) complexes of N 4 -alkyl-2-acetylpyridine thiosemicarbazones inhibits the activity of DNA synthesized in L1210 and P388 cell cultures.…”