Spectral characteristics of the cortex EEG for activation of the serotoninergic structures of the neocortex

Mamedov, Z. G.; Ignat’ev, D. A.

doi:10.1007/bf01186019

Cited by 2 publications

(2 citation statements)

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“…They reported that pharmacological stimulation of α 2 receptors suppresses impulsation of NA-ergic neurons and is accompanied by sedative (calming) effects. It is also known that an artificial increase in the serotonin concentration in the rabbit neocortex partially blocks theta EEG rhythm, and this is interpreted as a manifestation of the inhibitory processes [16]. Probably, these data allow one to interpret the results of experiments on rats, where bemitil in the same dose (50 mg/kg) suppressed most behavioral physiological reactions of the animals.…”

Section: Discussionmentioning

confidence: 93%

Effects of Bemitil on the Activity of Noradrenergic and Serotonergic Brainstem Neurons and on EEG of Awake Cats

et al. 2005

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In experiments on five awake cats, we studied the effects of bemitil, a drug possessing psychostimulatory, antidepressive, and actoprotector properties (peroral introduction, 50 mg/kg), on the activity of neurons of the aminergic cerebral systems. Eleven noradrenergic (NA-ergic) neurons of the locus coeruleus (LC) and 11 serotonergic (ST-ergic) neurons of the nuclei raphe (NR) were examined. A control experimental series was carried out on 8 NA-ergic neurons of the LC and 8 ST-ergic neurons of the NR. Bemitil was found to exert opposite effects on the impulse activity of NA-ergic and ST-ergic brainstem neurons; it suppressed impulsation of LC neurons and increased the spiking frequency of NR neurons within certain time intervals after its introduction. Analysis of EEG showed that bemitil decreased the spectral power of the delta and theta activities, which was accompanied by behavioral relaxation.

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Section: Discussionmentioning

confidence: 93%

Effects of Bemitil on the Activity of Noradrenergic and Serotonergic Brainstem Neurons and on EEG of Awake Cats

et al. 2005

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“…The analysis of EEG rhythms recorded upon the action of 150 mg/kg bemitil shows that the somnogenic effect of this preparation is related to an increase in the SPs of the delta and alpha rhythms in a parallel manner with suppression of the theta rhythm. As some authors believe [19], this situation reflects the entry of the animal into a stage of slow-wave sleep that is characterized by highamplitude slow oscillations of the delta range and by alpha spindles. As to the theta activity, the reaction of desynchronization in cats is determined by alternation of the alpha and theta rhythm segments [20]; in this case, the decrease in the theta rhythm SP appears quite natural.…”

Section: Discussionmentioning

confidence: 96%

Effects of Bemitil on Electrical Activity of the Aminergic Systems and Cerebral Cortex in Awake Cats

Kolotilova

Korenyuk

2009

Neurophysiology

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Under conditions of chronic experiments on awake cats, we studied changes in the impulse activity generated by brainstem monoaminergic neurons and also in the background field electrical activity of the neocortex induced by peroral administration of 150 mg/kg bemitil. In supposedly serotonergic neurons of the n. raphe, upon the action of this agent, the frequency of spike generation underwent two-phase modifications. Five to 20 min after administration of bemitil, a decrease (insignificant) in the frequency was followed by an increase (on the 35th min, the frequency began to significantly exceed the initial values, P < 0.05). Beginning from the 5th min of the exposure, discharges of noradrenergic neurons of the locus coeruleus were unidirectionally and significantly (P < 0.05) suppressed. With parallel EEG recording, we observed changes in the spectral powers (SPs) of separate rhythms; the SPs of alpha and delta oscillations increased, while the power of the theta rhythm dropped. We compared the effects of bemitil administered in different doses (50, 100, and 150 mg/kg). Possible mechanisms underlying the effect of bemitil on the functioning of cerebral mechanisms are discussed.

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Spectral characteristics of the cortex EEG for activation of the serotoninergic structures of the neocortex

Cited by 2 publications

References 2 publications

Effects of Bemitil on the Activity of Noradrenergic and Serotonergic Brainstem Neurons and on EEG of Awake Cats

Effects of Bemitil on the Activity of Noradrenergic and Serotonergic Brainstem Neurons and on EEG of Awake Cats

Effects of Bemitil on Electrical Activity of the Aminergic Systems and Cerebral Cortex in Awake Cats

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