Spectral and thermal studies of 4-(1H-pyrazolo {3,4-d} pyrimidin-4-ylazo) benzene-1,3-diol complexes of cobalt(II), nickel(II) and copper(II)

Gaber, Mohamed; El-Baradie, Kamal Y.; El-Sayed, Yusif S.

doi:10.1016/j.saa.2007.05.001

Cited by 30 publications

(18 citation statements)

References 43 publications

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“…In continuation of our previous work concerning metal complexes based on azo compounds, in the work reported here we aimed to synthesis Cu(II) azo complexes with our target ligand. Structural characterization was performed using elemental analysis, magnetic measurements, thermal studies as well as various spectroscopic techniques such as infrared (IR), UV–visible, NMR, mass and electron spin resonance (ESR).…”

Section: Introductionmentioning

confidence: 99%

2,4‐Dihydroxy‐5‐[(5‐mercapto‐1H‐1,2,4‐triazole‐3‐yl)diazenyl]benzaldehyde acetato, chloro and nitrato Cu(II) complexes: Synthesis, structural characterization, DNA binding and anticancer and antimicrobial activity

Gaber

Fathalla

El‐Ghamry

2019

Applied Organom Chemis

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Acetato, chloro and nitrato Cu(II) complexes of a novel azo compound, namely 2,4‐dihydroxy‐5‐[(5‐mercapto‐1H‐1,2,4‐triazole‐3‐yl)diazenyl]benzaldehyde, have been prepared. The stoichiometry, stereochemistry and bonding fashion of these copper chelates were deduced via elemental analyses, spectral methods and conductivity and magnetic measurements. Infrared spectral data confirmed the participation of azo N atom and the deprotonated OH group. UV–visible spectral data and magnetic measurements indicated octahedral stereo‐structure for the acetato and nitrato compounds and square planer for the chloro compound. Thermogravimetric analysis was applied to investigate the thermal degradation of the metal chelates. The thermo‐kinetic parameters were computed. The molecular modeling technique was used to support the predicted geometry of the prepared chelates. The interaction between the Cu(II) complexes and calf thymus DNA was studied using two techniques: absorption and viscosity measurements. The values of binding constant obtained from the absorption spectral method were calculated and found to be 4.23 × 104, 26.93 × 104, 13.01 × 104 and 5.36 × 104 M−1 for ligand and acetato, chloro and nitrato complexes, respectively. The antimicrobial activities were evaluated against various bacterial and fungi strains. The in vitro antitumor efficacy of the synthesized compounds was investigated against the HEPG2 cell line.

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Section: Introductionmentioning

confidence: 99%

2,4‐Dihydroxy‐5‐[(5‐mercapto‐1H‐1,2,4‐triazole‐3‐yl)diazenyl]benzaldehyde acetato, chloro and nitrato Cu(II) complexes: Synthesis, structural characterization, DNA binding and anticancer and antimicrobial activity

Gaber

Fathalla

El‐Ghamry

2019

Applied Organom Chemis

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“…Heterocyclic azo dyes occupy a great position in the growth of coordination chemistry. The prominence of such compounds arises from their biological effectiveness in addition to their analytical applications . On the other hand, derivatives of heterocyclic azo dyes have been utilized to settle the depressed oxidation states of diverse transition metal elements .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structural characterization and DNA binding affinity of new bioactive nano‐sized transition metal complexes with sulfathiazole azo dye for therapeutic applications

Saad

El‐Ghamry

Kassem

2019

Applied Organom Chemis

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The azo dye ligand 4‐(5‐chloro‐2‐hydroxyphenylazo)‐N‐thiazol‐2‐ylbenzenesulfonamide (H2L) formed by the coupling reaction of sulfathiazole and p‐chlorophenol was synthesized and characterized using elemental analysis and Fourier transform infrared (FT‐IR) as well as UV–visible spectra. Nano‐sized divalent Cu, Co, Ni, Mn and Zn complexes of the synthesized azo dye ligand were prepared and investigated using various spectroscopic and analytical techniques. Elemental and thermal analyses indicated the formation of the Cu(II), Ni(II) and Mn(II) complexes in a molar ratio of 1:2 (L:M) while Co(II) and Zn(II) complexes exhibited a 1:1 (M:L) ratio. FT‐IR spectral studies confirmed the coordination of the ligand to the metal ions through the phenolic hydroxyl oxygen, azo nitrogen, sulfonamide oxygen and/or thiazole nitrogen. The geometric arrangements around the central metal ions were investigated applying UV–visible and electron spin resonance spectra, thermogravimetric analysis and molar conductance measurements. X‐ray diffraction patterns revealed crystalline nature of H2L and amorphous nature of all synthesized complexes. Transmission electron microscopy images confirmed nano‐sized particles and their homogeneous distribution over the complex surface. Antibacterial, antifungal and antitumour activities of the investigated complexes were screened compared with familiar standard drugs to confirm their potential therapeutic applications. The Cu(II) complex showed IC50 of 3.47 μg ml−1 (5.53 μM) against hepatocellular carcinoma cells, which means that it is a more potent anticancer drug compared with the standard cisplatin (IC50 = 3.67 μg ml−1 (12.23 μM)). Furthermore, the Co(II), Ni(II), Cu(II) and Zn(II) complexes displayed IC50 greater than that of an applied standard anticancer agent (5‐flurouracil) towards breast carcinoma cells. Hence, these complexes can be considered as promising anticancer drugs. The mode of binding of the complexes with salmon serum DNA was determined through electronic absorption titration and viscosity studies.

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“…Heterocyclic azodyes have been used as chromogenes in spectrophotometric determination of copper (II) ions. These azodyes are 2-amino-5-bromopyridylazo resorcinol [4], 1-[pyridyl 2-azo]-naphthol (PAN) [5,6], and its derivatives are 1-(2-thiazolylazo)-2-naphthol [7], 1-(5 bromo-2-pyridylazo)-2-naphthol-6-sulphonic acid [8], 2,6-bis(4-sulfo-1-hydroxy-2 naphth alazo) pyridine [9], 4-(1H-pyrazolo 3,4-d}pyrimidin-4-ylazo) benzene-1,3-diol [10], 4-(p-Nitrophenylazo)-2-amino-3-pyridinol [11], l-(2-quinolylazo)-2,4,5 trihydroxybenzene [12], bromosulphonazo III [13] and alizarin red S [14]. These dyes are highly sensitive but lack of the selectivity.…”

Section: Introductionmentioning

confidence: 99%

Analytical and Biological Evaluation of Two Schiff?s Bases: Spectrophotometeric Analysis of Copper (II) in Water and Soil Samples

Kumar¹,

Kanchi²

2014

J Environ Anal Chem

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Spectral and thermal studies of 4-(1H-pyrazolo {3,4-d} pyrimidin-4-ylazo) benzene-1,3-diol complexes of cobalt(II), nickel(II) and copper(II)

Cited by 30 publications

References 43 publications

2,4‐Dihydroxy‐5‐[(5‐mercapto‐1H‐1,2,4‐triazole‐3‐yl)diazenyl]benzaldehyde acetato, chloro and nitrato Cu(II) complexes: Synthesis, structural characterization, DNA binding and anticancer and antimicrobial activity

2,4‐Dihydroxy‐5‐[(5‐mercapto‐1H‐1,2,4‐triazole‐3‐yl)diazenyl]benzaldehyde acetato, chloro and nitrato Cu(II) complexes: Synthesis, structural characterization, DNA binding and anticancer and antimicrobial activity

Synthesis, structural characterization and DNA binding affinity of new bioactive nano‐sized transition metal complexes with sulfathiazole azo dye for therapeutic applications

Analytical and Biological Evaluation of Two Schiff?s Bases: Spectrophotometeric Analysis of Copper (II) in Water and Soil Samples

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