Spectral and spatial distribution of subthalamic beta peak activity in Parkinson's disease patients

Darcy, Natasha; Lofredi, Roxanne; Al‐Fatly, Bassam; Neumann, Wolf‐Julian; Hübl, Julius; Brücke, Christof; Krause, Patricia; Schneider, Gerd‐Helge; Kühn, Andrea A.

doi:10.1016/j.expneurol.2022.114150

Cited by 45 publications

(43 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, we could replicate recurring findings from the literature that used elevated activity within the beta band to guide postoperative contact selection [ 3 , 4 , 5 , 14 , 15 , 16 ] and showed that the distribution of peak beta activity followed a distinct anatomical pattern, similar to previously identified sweet spots [ 26 , 27 ]. As hypothesized, based on elevated beta activity, we could identify effective monopolar contacts.…”

Section: Discussionsupporting

confidence: 80%

“…This is in accordance with the notion that LFPs cover a spatial extent of several hundred microns around the electrode contact [ 24 ]. All coordinates and data points of the right hemisphere were non-linearly flipped onto the left hemisphere, and vice versa, and were finally pooled across hemispheres to enhance the number of data points for analysis [ 25 , 26 ]. This resulted in a point cloud corresponding to the distribution of beta activity values in anatomical space.…”

Section: Methodsmentioning

confidence: 99%

“…For visualization purposes, a linear interpolant was calculated to estimate activity values in the empty space between coordinates. To validate the feasibility of the algorithm we calculated the distance between the coordinates and previously identified anatomical [ 27 ] and electrophysiological [ 26 ] sweet spots. The center of gravity (left hemisphere) as reported by the authors was used for calculation (anatomical sweet spot: x = −12.5, y = −12.72, z = −5.38; electrophysiological sweet spot: x = −12.2, y = −12.5, z = −6.4).…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Local Field Potential-Guided Contact Selection Using Chronically Implanted Sensing Devices for Deep Brain Stimulation in Parkinson’s Disease

et al. 2022

View full text Add to dashboard Cite

Intra- and perioperatively recorded local field potential (LFP) activity of the nucleus subthalamicus (STN) has been suggested to guide contact selection in patients undergoing deep brain stimulation (DBS) for Parkinson’s disease (PD). Despite the invention of sensing capacities in chronically implanted devices, a comprehensible algorithm that enables contact selection using such recordings is still lacking. We evaluated a fully automated algorithm that uses the weighted average of bipolar recordings to determine effective monopolar contacts based on elevated activity in the beta band. LFPs from 14 hemispheres in seven PD patients with newly implanted directional DBS leads of the STN were recorded. First, the algorithm determined the stimulation level with the highest beta activity. Based on the prior determined level, the directional contact with the highest beta activity was chosen in the second step. The mean clinical efficacy of the contacts chosen using the algorithm did not statistically differ from the mean clinical efficacy of standard contact selection as performed in clinical routine. All recording sites were projected into MNI standard space to investigate the feasibility of the algorithm with respect to the anatomical boundaries of the STN. We conclude that the proposed algorithm is a first step towards LFP-based contact selection in STN-DBS for PD using chronically implanted devices.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Local Field Potential-Guided Contact Selection Using Chronically Implanted Sensing Devices for Deep Brain Stimulation in Parkinson’s Disease

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Most DBS centers, however, do not have access to high-field MRI, and even with such imaging facilities the definitive location and orientation of the DBS lead implant can only be confirmed, as shown in this study, with post-mortem histology. Previous studies have also shown that resting-state local field potentials filtered in the beta-band (12-30 Hz) can be useful for intra-operative targeting of DBS lead implants in the dorsolateral ‘motor’ STN, but again the exact location of the spectral feature can vary be several millimeters, especially considering the necessity to use bipolar electrode montages [31]. In this way, the ECAP approach may be a valuable complement for clinicians to use with current methods.…”

Section: Discussionmentioning

confidence: 99%

Classification of electrically-evoked compound action potentials in the parkinsonian subthalamic nucleus region

Rosing

Doyle

Brinda

et al. 2022

Preprint

View full text Add to dashboard Cite

BackgroundElectrically evoked compound action potentials (ECAPs) generated in the subthalamic nucleus (STN) contain features that may be useful for titrating deep brain stimulation (DBS) therapy for Parkinson’s disease. While previous studies have leveraged macroscale DBS electrodes, directional DBS leads with split-band contacts are thought to enable sampling ECAPs at a higher spatial resolution both within and adjacent to the STN.ObjectiveIn this study, we investigated the spatiotemporal features of ECAPs in and around the STN across parameter sweeps of stimulation current amplitude, pulse width, and electrode configuration.MethodsFour non-human primates were implanted unilaterally with either a directional (n=3) or non-directional (n=1) DBS lead targeting the sensorimotor STN. Resting-state ECAPs were recorded before and after rendering the subjects parkinsonian with MPTP treatments.ResultsECAP responses were characterized by primary features (within 1.6ms after a stimulus pulse) and secondary features (between 1.6-7.4ms after a stimulus pulse). Using these ECAP features, a linear classifier was able to differentiate electrodes within and dorsal to the STN in all four subjects.ConclusionECAP responses varied systematically with recording and stimulating electrode location, which may provide utility in efficiently defining DBS electrode configurations to target pathways in and around the STN for treating symptoms of Parkinson’s disease.

show abstract

“…Most DBS centers, however, do not have access to high-eld MRI, and even with such imaging facilities the de nitive location and orientation of the DBS lead implant can only be con rmed, as shown in this study, with post-mortem histology. Previous studies have also shown that resting-state local eld potentials ltered in the beta-band (12-30 Hz) can be useful for intraoperative targeting of DBS lead implants in the dorsolateral 'motor' STN, but again the exact location of the spectral feature can vary be several millimeters, especially considering the necessity to use bipolar electrode montages [31]. In this way, the ECAP approach may be a valuable complement for clinicians to use with current methods.…”

Section: Discussionmentioning

confidence: 99%

Classification of electrically-evoked compound action potentials in the parkinsonian subthalamic nucleus region

Rosing

Doyle

Brinda

et al. 2022

Preprint

View full text Add to dashboard Cite

Electrically evoked compound action potentials (ECAPs) generated in the subthalamic nucleus (STN) contain features that may be useful for titrating deep brain stimulation (DBS) therapy for Parkinson’s disease. Delivering a strong therapeutic effect with DBS therapies, however, relies on selectively targeting neural pathways to avoid inducing side effects. In this study, we investigated the spatiotemporal features of ECAPs in and around the STN across parameter sweeps of stimulation current amplitude, pulse width, and electrode configuration, and used a linear classifier of ECAP responses to predict electrode location. Four non-human primates were implanted unilaterally with either a directional (n = 3) or non-directional (n = 1) DBS lead targeting the sensorimotor STN. ECAP responses were characterized by primary features (within 1.6 ms after a stimulus pulse) and secondary features (between 1.6–7.4 ms after a stimulus pulse). Using these ECAP features, a linear classifier was able to accurately differentiate electrodes within the STN versus dorsal to the STN in all four subjects. ECAP responses varied systematically with recording and stimulating electrode locations, which provides a subject-specific neuroanatomical basis for selecting electrode configurations in the treatment of Parkinson’s disease with DBS therapy.

show abstract

Spectral and spatial distribution of subthalamic beta peak activity in Parkinson's disease patients

Cited by 45 publications

References 64 publications

Local Field Potential-Guided Contact Selection Using Chronically Implanted Sensing Devices for Deep Brain Stimulation in Parkinson’s Disease

Local Field Potential-Guided Contact Selection Using Chronically Implanted Sensing Devices for Deep Brain Stimulation in Parkinson’s Disease

Classification of electrically-evoked compound action potentials in the parkinsonian subthalamic nucleus region

Classification of electrically-evoked compound action potentials in the parkinsonian subthalamic nucleus region

Contact Info

Product

Resources

About