Spectral analysis of heart rate variability for trauma outcome prediction: an analysis of 210 ICU multiple trauma patients

Luo, Xiaomin; Gao, Haijun; Yu, Xingxia; Jiang, Zongping; Yang, Wenchao

doi:10.1007/s00068-019-01175-5

Cited by 6 publications

(10 citation statements)

References 38 publications

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“…This pattern can also be seen in patients with poor prognosis and higher mortality with severe sepsis 29 , postoperative patients with acute respiratory distress syndrome (ARDS) 30 , patients after myocardial infarction 31 , chronic heart failure 32 , left ventricular dysfunction 33 , polytraumatized patients 34 , or in chronic diseases 35 .…”

Section: Discussionmentioning

confidence: 99%

Prospective multicenter study of heart rate variability with ANI monitor as predictor of mortality in critically ill patients with COVID-19

Aragón-Benedí

Caballero-Lozada²,

Pérez-Calatayud³

et al. 2022

Sci Rep

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The purpose of this study is to demonstrate that the most critically ill patients with COVID-19 have greater autonomic nervous system dysregulation and assessing the heart rate variability, allows us to predict severity and 30-day mortality. This was a multicentre, prospective, cohort study. Patients were divided into two groups depending on the 30-day mortality. The heart rate variability and more specifically the relative parasympathetic activity (ANIm), and the SDNN (Energy), were measured. To predict severity and mortality multivariate analyses of ANIm, Energy, SOFA score, and RASS scales were conducted. 112 patients were collected, the survival group (n = 55) and the deceased group (n = 57). The ANIm value was higher (p = 0.013) and the Energy was lower in the deceased group (p = 0.001); Higher Energy was correlated with higher survival days (p = 0.009), and a limit value of 0.31 s predicted mortalities with a sensitivity of 71.9% and a specificity of 74.5%. Autonomic nervous system and heart rate variability monitoring in critically ill patients with COVID-19 allows for predicting survival days and 30-day mortality through the Energy value. Those patients with greater severity and mortality showed higher sympathetic depletion with a predominance of relative parasympathetic activity.

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Section: Discussionmentioning

confidence: 99%

Prospective multicenter study of heart rate variability with ANI monitor as predictor of mortality in critically ill patients with COVID-19

Aragón-Benedí

Caballero-Lozada²,

Pérez-Calatayud³

et al. 2022

Sci Rep

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“…Overall, 113 cohorts from 106 studies using 10 MOF definitions were included. Four scoring systems were used: Denver (three different cutoff values), 4,7,9,18–43 Goris (two different cutoff values), 5,44–53 Marshall (four different cutoff values), 9,19,54–83 and Sequential Organ Failure Assessment (SOFA) (two different cutoff values) 8,10,11,19,84–115 . See Table 1.…”

Section: Systematic Reviewmentioning

confidence: 99%

Incidence of multiple organ failure in adult polytrauma patients: A systematic review and meta-analysis

Ting

Lewis

Yang

et al. 2023

J Trauma Acute Care Surg

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BACKGROUND Postinjury multiple organ failure (MOF) is the leading cause of late death in trauma patients. Although MOF was first described 50 years ago, its definition, epidemiology, and change in incidence over time are poorly understood. We aimed to describe the incidence of MOF in the context of different MOF definitions, study inclusion criteria, and its change over time. METHODS Cochrane Library, EMBASE, MEDLINE, PubMed, and Web of Science databases were searched for articles published between 1977 and 2022 in English and German. Random-effects meta-analysis was performed when applicable. RESULTS The search returned 11,440 results, of which 842 full-text articles were screened. Multiple organ failure incidence was reported in 284 studies that used 11 unique inclusion criteria and 40 MOF definitions. One hundred six studies published from 1992 to 2022 were included. Weighted MOF incidence by publication year fluctuated from 11% to 56% without significant decrease over time. Multiple organ failure was defined using four scoring systems (Denver, Goris, Marshall, Sequential Organ Failure Assessment [SOFA]) and 10 different cutoff values. Overall, 351,942 trauma patients were included, of whom 82,971 (24%) developed MOF. The weighted incidences of MOF from meta-analysis of 30 eligible studies were as follows: 14.7% (95% confidence interval [CI], 12.1–17.2%) in Denver score >3, 12.7% (95% CI, 9.3–16.1%) in Denver score >3 with blunt injuries only, 28.6% (95% CI, 12–45.1%) in Denver score >8, 25.6% (95% CI, 10.4–40.7%) in Goris score >4, 29.9% (95% CI, 14.9–45%) in Marshall score >5, 20.3% (95% CI, 9.4–31.2%) in Marshall score >5 with blunt injuries only, 38.6% (95% CI, 33–44.3%) in SOFA score >3, 55.1% (95% CI, 49.7–60.5%) in SOFA score >3 with blunt injuries only, and 34.8% (95% CI, 28.7–40.8%) in SOFA score >5. CONCLUSION The incidence of postinjury MOF varies largely because of lack of a consensus definition and study population. Until an international consensus is reached, further research will be hindered. LEVEL OF EVIDENCE Systematic Review and Meta-analysis; Level III.

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“…The Axis checklist has 20 questions with response of either a yes (1) or a no (0) [32]. Study quality will be further categorized as low (<10), moderate (10)(11)(12)(13)(14)(15) and high (>15) as previously used [33]. The final quality assessment score of each study will be documented and displayed on the quality appraisal table.…”

Section: Risk Of Bias In Individual Studiesmentioning

confidence: 99%

“…Owing to HRV's ability to indicate somatic tissue damage before the onset of pain and the injury [9], HRV has also been proposed as a new vital sign and triage tool in trauma settings [10][11][12]. In addition to being an objective marker of autonomic function [13], HRV has also been shown to be a robust marker of injury severity and as a predictor of morbidity and mortality in patients with severe traumatic injuries to head, neck, torso, abdomen [14], burns [15], and Traumatic Brain Injury (TBIs) [16].…”

Section: Introductionmentioning

confidence: 99%

Association between non-acute traumatic injury (TI) and heart rate variability (HRV) in adults: A systematic review protocol

et al. 2022

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Heart Rate Variability (HRV) is an indirect measure of autonomic function. Attenuated HRV is linked to worsening health outcomes including Major Adverse Cardiovascular Events (MACE). The relationship between traumatic injury (TI) and HRV has been limitedly studied. This research protocol has been designed to conduct a systematic review of the existing evidence on the association between non-acute TI and HRV in adults. Four electronic bibliographic databases (Web of Science, CINAHL, Medline, and Scopus) will be searched. The studies on non-acute (>7 days post injury) TI and HRV in adults will be included, followed by title-abstract screening by two reviewers independently. The quality and risk of bias of the included studies will be assessed using Axis and a six-item Risk of Bias Assessment tool for of Non-randomized Studies (RoBANS) respectively. Grading of Recommendations Assessment, Development and Evaluation (GRADE) will assess the quality of evidence. The extracted data will be synthesized using narrative syntheses and a Forest plot with or without meta-analysis- whichever permitted by the pooled data. This will be the first systematic review to examine the relationship between generalized TI and HRV in adults. Trial registration: (PROPSERO registration number: CRD: CRD42021298530) https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021298530.

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Spectral analysis of heart rate variability for trauma outcome prediction: an analysis of 210 ICU multiple trauma patients

Cited by 6 publications

References 38 publications

Prospective multicenter study of heart rate variability with ANI monitor as predictor of mortality in critically ill patients with COVID-19

Prospective multicenter study of heart rate variability with ANI monitor as predictor of mortality in critically ill patients with COVID-19

Incidence of multiple organ failure in adult polytrauma patients: A systematic review and meta-analysis

Association between non-acute traumatic injury (TI) and heart rate variability (HRV) in adults: A systematic review protocol

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