Spectral Analysis of Heart Rate Variability: An Emerging Tool for Assessing Stability During Transition to Extrauterine Life

Verklan, M. Terese; Padhye, Nikhil

doi:10.1177/0884217504263301

Cited by 35 publications

(39 citation statements)

References 37 publications

(36 reference statements)

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“…Specifically, injury to the right cerebral cortex (corresponding to the cortical region supplied by the middle cerebral artery [MCA]) and the right cerebellar hemisphere was related to a decreased LF/HF ratio, a ratio reflecting sympathovagal balance [1,3], whereas injuries to the same areas on the left were associated with an increased LF/HF ratio. Spectral power of the individual LF and HF components of HRV did not show a significant independent association with the location of cerebral injury.…”

Section: Discussionmentioning

confidence: 99%

“…Mediation of cardiovascular and respiratory coordination is an important ANS function. Heart rate variability (HRV) indices and spectral HRV analysis are an established method to assess autonomic function as they reflect the ANS's components (e.g., parasympathetic and sympathetic function) and their different contributions to the overall heart-rate patterns [1,3,4]. Specifically, variability in the high frequency (HF) range represents parasympathetic activity and low frequency (LF) range variability is attributed to mainly sympathetic activity (with parasympathetic contribution).…”

Section: Introductionmentioning

confidence: 99%

“…The autonomic nervous system (ANS) is critical for fetal adaptation to stress, successful transition from fetal to extrauterine life, and appropriate neonatal responses to internal and external environmental signals [1,2]. Mediation of cardiovascular and respiratory coordination is an important ANS function.…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, variability in the high frequency (HF) range represents parasympathetic activity and low frequency (LF) range variability is attributed to mainly sympathetic activity (with parasympathetic contribution). The LF/HF ratio thus serves as an indicator of sympathovagal balance [1,3].…”

Section: Introductionmentioning

confidence: 99%

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Effects of regional brain injury on the newborn autonomic nervous system

Sender

Govindan

Sulemanji

et al. 2014

Early Human Development

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of regional brain injury on the newborn autonomic nervous system

Sender

Govindan

Sulemanji

et al. 2014

Early Human Development

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“…We also analyzed temperatureinduced changes in heart rate variability (HRV), hypothesized to be an indicator of stress in newborns and a predictor of a wide range of adverse health outcomes [10][11][12] . To our knowledge, there are no reports of the effects of cooling and rewarming on HRV in newborns.…”

mentioning

confidence: 99%

Changes in the PQRST Intervals and Heart Rate Variability Associated with Rewarming in Two Newborns Undergoing Hypothermia Therapy

et al. 2009

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Background: Little is known about the effects of hypothermia therapy and subsequent rewarming on the PQRST intervals and heart rate variability (HRV) in term newborns with hypoxic-ischemic encephalopathy (HIE). Objectives: This study describes the changes in the PQRST intervals and HRV during rewarming to normal core body temperature of 2 newborns with HIE after hypothermia therapy. Methods: Within 6 h after birth, 2 newborns with HIE were cooled to a core body temperature of 33.5°C for 72 h using a cooling blanket, followed by gradual rewarming (0.5°C per hour) until the body temperature reached 36.5°C. Custom instrumentation recorded the electrocardiogram from the leads used for clinical monitoring of vital signs. Generalized linear mixed models were calculated to estimate temperature-related changes in PQRST intervals and HRV. Results: For every 1°C increase in body temperature, the heart rate increased by 9.2 bpm (95% CI 6.8–11.6), the QTc interval decreased by 21.6 ms (95% CI 17.3–25.9), and low and high frequency HRV decreased by 0.480 dB (95% CI 0.052–0.907) and 0.938 dB (95% CI 0.460–1.416), respectively. Conclusions: Hypothermia-induced changes in the electrocardiogram should be monitored carefully in future studies.

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