Spectral analysis of electrograms during ventricular tachycardia in a canine model

Spectral characterisation of ventricular intracardiac potentials in human post-ischaemic bipolar electrograms

“…0–20 Hz) than all the other physiological and pathological types, which, however, gradually decreased when moving towards higher sub-bands. These findings are at least partially in accordance with previous scientific studies on post-ischaemic epicardial EGMs 39 , 40 . In fact, Mor-Avi and Akselrod 39 demonstrated that myocardial ischaemia is responsible for a shift of the major frequency contents below 40 Hz whilst attenuating high-frequency spectral components.…”

“…In fact, Mor-Avi and Akselrod 39 demonstrated that myocardial ischaemia is responsible for a shift of the major frequency contents below 40 Hz whilst attenuating high-frequency spectral components. Sierra et al 40 concluded that most of the signal energy is concentrated below 30 Hz in monomorphic and polymorphic VT recordings. Relative powers of LP2 and EP exhibited significantly greater values from 40 Hz than post-ischaemic physiological potentials, even though statistical significance was not achieved on some spectral ranges (see Table 1 ).…”

“…However, to the best of our knowledge, no spectral characterisation of AVPs and post-ischaemic physiological potentials from intracardiac bipolar recordings has been performed so far. In fact, spectral analysis and time–frequency analysis techniques have been previously exploited on ventricular EGMs only with the goal of identifying short-term frequency content variations induced by myocardial ischaemia 39 , distinguishing monomorphic and polymorphic VTs 40 , local and distant electrical activities 41 and VT EGMs from normal sinus rhythm ones 42 , 43 , or targeting arrhythmogenic sites 36 – 38 , but not to identify peculiar signatures of AVPs in the frequency domain. A study 44 investigating the effect of post-myocardial infarct on the frequency characteristics of ovine unipolar recordings acquired by multi-electrode plunge needles determined the relationship between high-frequency spectral characteristics and arrhythmogenic substrates.…”