Satellite instruments are nowadays a very important source of information. The physical quantities (essential variables) derived from satellites are utilized in a wide field of applications, in particular in atmospheric physics and geoscience. In contrast to ground measurements the physical quantities are not directly measured, but have to be retrieved from satellite observations. Satellites observe hereby the reflection or emission of radiation by the Earth's surface or atmosphere, which enables the retrieval of respective physical quantities (essential variables). The physical basis for the retrieval is the interaction of the radiation with the Earth's atmosphere and surface. This interaction is defined by radiative transfer, which favors the use of radiances and their respective units within retrieval methods.However, the primary measurement quantity (unit) of the sensors consists of voltage or digital counts. Hence, calibration has to be applied in order to relate the digital counts (voltage) given by the sensor to the incoming radiances, consequently, the physical units of interest. The relation between the digital counts and the radiances (calibration coefficients) can be derived by comparison of the sensor signal with an absolute standard reference prior to launch. Nowadays, satellite instruments are usually well designed and calibrated prior to launch. Unfortunately, no matter how sophisticated the instruments are, once in space they degrade with time, e.g., due to thermal, mechanical or electrical effects or exposure to UV radiation. Yet, for the majority of remote sensing retrievals and applications calibrated data are essential. Sensor re-calibration (hereafter referred to as calibration) is therefore the basis of reliable remote sensing and ensuring the quality of the derived variables and products. However, after-launch comparison with reference standards of known accuracy is difficult to manage in terms of metrology. On-board calibration units being interpreted as the reference standard are subject to degradation processes as well, especially in the visible spectra. Moreover, many satellite sensors (especially in the visible spectra) are not adjusted by on-board calibration. Hence, in any case, post launch calibration is quite a challenging task, but is essential for physically defined retrieval of essential variables.