Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhoea. Observation of resistant strains of Neisseria gonorrhoeae.

Reyn, Alice; Schmidt, Henning; Trier, Mogens; Bentzon, Michael Weis

doi:10.1136/sti.49.1.54

Cited by 36 publications

(18 citation statements)

References 13 publications

(6 reference statements)

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“…However, the isolation of f8-lactamase-producing (1,4,10) and spectinomycin-resistant (11,18) strains demonstrates the ability of N. gonorrhoeae to develop resistance to therapeutic agents. Therefore, currently available antimicrobial agents should be evaluated for potential therapeutic value against gonococcal infections.…”

mentioning

confidence: 99%

In Vitro Activity of Rosamicin, Josamycin, Erythromycin, and Clindamycin Against β-Lactamase-Negative and β-Lactamase-Positive Strains of Neisseria gonorrhoeae

Biddle

Thornsberry

1979

Antimicrob Agents Chemother

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Randomly selected strains of β-lactamase-negative and β-lactamase-positive Neisseria gonorrhoeae were tested by an agar dilution method for susceptibility to rosamicin, josamycin, erythromycin, clindamycin, and penicillin G. Rosamicin was more active than erythromycin, which was more active than josamycin or clindamycin; the latter two were similar in their activity. The susceptibility to the macrolide antibiotics and clindamycin was independent of β-lactamase production, but the penicillin minimal inhibitory concentrations were higher in the β-lactamase-positive group because of the enzyme.

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mentioning

confidence: 99%

In Vitro Activity of Rosamicin, Josamycin, Erythromycin, and Clindamycin Against β-Lactamase-Negative and β-Lactamase-Positive Strains of Neisseria gonorrhoeae

Biddle

Thornsberry

1979

Antimicrob Agents Chemother

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“…We consider spectinomycin hydrochloride to be the drug of choice for the treatment of uncomplicated gonococcal infections in patients (6). Careful surveillance will have to be maintained for the appearance of highly resistant isolates in other areas.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Spectinomycin Hydrochloride and Aqueous Procaine Penicillin G in the Treatment of Uncomplicated Gonorrhea

Duancic

Fiumara

Alpert

et al. 1974

Antimicrob Agents Chemother

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Men and women with uncomplicated gonorrhea were randomly assigned to receive aqueous procaine penicillin G (2,400,000 U for men; 2,400,000 U daily for 2 days for women) or spectinomycin hydrochloride (2.0 g for men; 4.0 g for women). Among men who returned for post-treatment evaluation within 10 days, treatment failures were noted among 16 (20.3%) of 79 men who received penicillin and 8 (9.5%) of 84 men who received spectinomycin (P < 0.1). Similarly, 6 (13.3%) of 45 women who received penicillin and 3 (6.5%) of 46 women who received spectinomycin had positive endocervical cultures for Neisseria gonorrhoeae at the time of the post-treatment examination (P = not significant).

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“…Besides N. gonorrhoeae can rapidly develop resistance of high-level resistance by a single mutation, it was documented in the U.S., Korea and United Kingdom (Reyn, 1973;Ashford, 1981;Barry, 2009). …”

Section: Spectinomycinmentioning

confidence: 99%

Gonorrhea in Men Sex Men and Heterosexual Men

Famiglietti¹,

García²

2012

Sexually Transmitted Infections

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Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhoea. Observation of resistant strains of Neisseria gonorrhoeae.

Cited by 36 publications

References 13 publications

In Vitro Activity of Rosamicin, Josamycin, Erythromycin, and Clindamycin Against β-Lactamase-Negative and β-Lactamase-Positive Strains of Neisseria gonorrhoeae

In Vitro Activity of Rosamicin, Josamycin, Erythromycin, and Clindamycin Against β-Lactamase-Negative and β-Lactamase-Positive Strains of Neisseria gonorrhoeae

Comparison of Spectinomycin Hydrochloride and Aqueous Procaine Penicillin G in the Treatment of Uncomplicated Gonorrhea

Gonorrhea in Men Sex Men and Heterosexual Men

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