Spectinomycin hydrochloride in the treatment of uncomplicated gonorrhoea.

Abstract

In 1960 spectinomycin, a new broad spectrum antibiotic, was released for clinical investigation and it was shown that the administration of 2 g. of the sulphate salt was effective therapy in acute gonorrhoea yielding cure rates of approximately 87 to 95 per cent. in males. The cure rate in females was 92 per cent. with a 3 g. dose (Laird and Taylor, 1962; Wilcox, 1963;Tiedemann, Hackney, and Price, 1965;Sparling, Yobs, Billings, and Hackney, 1966 ResultsThe results of this study are summarised in the Table. Of 165 men treated, 108 returned for examination and there were no cases of treatment failure.Of the forty women treated with 2 g. doses, 29 were followed; the only patient from whom a positive culture was obtained admitted exposure to risk of infection during the observation period. If this case is considered to be a re-infection, the cure rate for the remaining 28 cases is 100 per cent.Among the 108 women who received 4 g., 67 of the 71 who returned for examination yielded negative results to cultures. Of the four in whom a positive culture was obtained after treatment, one was judged a re-infection on a history of further intercourse and three were considered to be due to failure of

In Vitro Antibacterial Activity of Spectinomycin

“…Concentrations of antibiotic exhibiting bactericidal activity exceeded the inhibitory concentration by at least fourfold. Regression graphs were plotted for results obtained with 30-, 100-, 200-, and 300-pg spectinomycin discs; tentative interpretative standards are proposed.Spectinomycin hydrochloride, a basic antibiotic prepared from Streptomyces spectabilis, has been found to be highly effective in the therapy of gonorrhea (2,3,5). Because, with the usually recommended dosages, peak concentrations of this agent in the blood may be about 100 jig/ml (9,11) and urinary concentrations may attain 1,000 ,g/ml, this investigation was undertaken to study the activity of spectinomycin against bacteria other than Neisseria gonorrhoeae.…”

“…Spectinomycin hydrochloride, a basic antibiotic prepared from Streptomyces spectabilis, has been found to be highly effective in the therapy of gonorrhea (2,3,5). Because, with the usually recommended dosages, peak concentrations of this agent in the blood may be about 100 jig/ml (9,11) and urinary concentrations may attain 1,000 ,g/ml, this investigation was undertaken to study the activity of spectinomycin against bacteria other than Neisseria gonorrhoeae.…”

Treatment of Gonorrhea with Spectinomycin Hydrochloride: Comparison with Standard Penicillin Schedules

“…Cornelius and Domescik found both 2 and 4 g of spectinomycin hydrochloride effective in 96% of women with uncomplicated gonorrhea (4).…”

“…Spectinomycin hydrochloride is a new parenteral antibiotic prepared from Streptomyces spectabilis which has shown promising results in the treatment of gonorrhea (4). It appears to be remarkably free from side effects and offers an advantage over oral preparations since it is given as a single injection in the clinic.…”

Derivatives of 4-dihydro-4-deoxy-4(R)-amino spectinomycin and their activity against susceptible and resistant Escherichia coli strains

“…Besides this bacteriostatic effect, spectinomycin is bactericidal for gonococci, causing cell lysis due to structural damage of the cytoplasmic membrane (33). Therefore, the antibiotic is currently used in treatment of gonorrhoea (7,9,20), particularly with the increasing penicillin resistance of these pathogens (2,5,31).…”