SPECT study with I-123-Ioflupane (DaTSCAN) in patients with essential tremor. Is there any correlation with Parkinson’s disease?

Gerasimou, George; Costa, Durval C.; Papanastasiou, Emmanouil; Bostanjiopoulou, S.; Arnaoutoglou, Marianthi; Moralidis, Efstratios; Aggelopoulou, T.; Gotzamani-Psarrakou, Anna

doi:10.1007/s12149-012-0577-4

Cited by 44 publications

(31 citation statements)

References 34 publications

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“…Moreover, two studies reported a mild reduction in striatal dopamine transporter binding in 60 ‘pure’ essential tremor patients compared to 59 healthy controls although less severe compared to 80 Parkinson's disease patients (Gerasimou et al, 2012; Isaias et al, 2008). The reduced dopaminergic uptake pattern differed between the studies.…”

Section: Resultsmentioning

confidence: 99%

“…Most scintigraphic studies looking into the basal ganglia found no dopaminergic deficits in essential tremor (Antonini et al, 2001; Asenbaum et al, 1998; Benamer et al, 2000; Breit et al, 2006; Brooks et al, 1992; Doepp et al, 2008; Isaias and Antonini, 2010; Wang et al, 2005) while two studies measured slight abnormalities (Gerasimou et al, 2012; Isaias et al, 2008). One study reported iron accumulation in the basal ganglia (Novellino et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

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Neuroimaging essentials in essential tremor: A systematic review

Sharifi

Nederveen

Booij

et al. 2014

NeuroImage: Clinical

123

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BackgroundEssential tremor is regarded to be a disease of the central nervous system. Neuroimaging is a rapidly growing field with potential benefits to both diagnostics and research. The exact role of imaging techniques with respect to essential tremor in research and clinical practice is not clear. A systematic review of the different imaging techniques in essential tremor is lacking in the literature.MethodsWe performed a systematic literature search combining the terms essential tremor and familial tremor with the following keywords: imaging, MRI, VBM, DWI, fMRI, PET and SPECT, both in abbreviated form as well as in full form. We summarize and discuss the quality and the external validity of each study and place the results in the context of existing knowledge regarding the pathophysiology of essential tremor.ResultsA total of 48 neuroimaging studies met our search criteria, roughly divided into 19 structural and 29 functional and metabolic studies. The quality of the studies varied, especially concerning inclusion criteria. Functional imaging studies indicated cerebellar hyperactivity during rest and during tremor. The studies also pointed to the involvement of the thalamus, the inferior olive and the red nucleus. Structural studies showed less consistent results.Discussion and conclusionNeuroimaging techniques in essential tremor give insight into the pathophysiology of essential tremor indicating the involvement of the cerebellum as the most consistent finding. GABAergic dysfunction might be a major premise in the pathophysiological hypotheses. Inconsistencies between studies can be partly explained by the inclusion of heterogeneous patient groups. Improvement of scientific research requires more stringent inclusion criteria and application of advanced analysis techniques. Also, the use of multimodal neuroimaging techniques is a promising development in movement disorders research. Currently, the role of imaging techniques in essential tremor in daily clinical practice is limited.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neuroimaging essentials in essential tremor: A systematic review

Sharifi

Nederveen

Booij

et al. 2014

NeuroImage: Clinical

123

View full text Add to dashboard Cite

show abstract

“…This finding can help differentiate parkinsonian syndromes (i.e. PD, multiple system atrophy, progressive supranuclear palsy) from essential tremor, or dementia with Lewy bodies (which overlaps diagnosis of PD) from Alzheimer’s disease (Bajaj et al, 2013; Gerasimou et al, 2012; Oliveira et al., 2015; Thiriez et al, 2015). However, it is important to realize that decreased 123 I -FP-CIT identifies the loss of dopaminergic neurons, which is not specific for PD.…”

Section: Neuroimaging Of Pdmentioning

confidence: 99%

Neuroimaging of Parkinson's disease: Expanding views

Weingarten

Sundman

Hickey

et al. 2015

Neuroscience & Biobehavioral Reviews

130

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Advances in molecular and structural and functional neuroimaging are rapidly expanding the complexity of neurobiological understanding of Parkinson’s disease (PD). This review article begins with an introduction to PD neurobiology as a foundation for interpreting neuroimaging findings that may further lead to more integrated and comprehensive understanding of PD. Diverse areas of PD neuroimaging are then reviewed and summarized, including positron emission tomography, single photon emission computed tomography, magnetic resonance spectroscopy and imaging, transcranial sonography, magnetoencephalography, and multimodal imaging, with focus on human studies published over the last five years. These included studies on differential diagnosis, co-morbidity, genetic and prodromal PD, and treatments from L-DOPA to brain stimulation approaches, transplantation and gene therapies. Overall, neuroimaging has shown that PD is a neurodegenerative disorder involving many neurotransmitters, brain regions, structural and functional connections, and neurocognitive systems. A broad neurobiological understanding of PD will be essential for translational efforts to develop better treatments and preventive strategies. Many questions remain and we conclude with some suggestions for future directions of neuroimaging of PD.

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“…These basic observations have been replicated and confirmed by several further studies, including more recent ones. The latter have reported on longer clinical follow-up periods of up to 3 y (47) and have focused on the same basic topic (48).…”

Section: Tremor Syndromesmentioning

confidence: 99%

Nigrostriatal Dopamine Terminal Imaging with Dopamine Transporter SPECT: An Update

Tatsch

Poepperl

2013

J Nucl Med

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Learning Objectives: On successful completion of this activity, participants should be able to describe (1) the radiopharmaceuticals used to evaluate nigrostriatal dopamine imaging; (2) the pattern of uptake of these radiopharmaceuticals in parkinsonian syndromes; and (3) the role of these radiopharmaceuticals in the evaluation of parkinsonian syndromes.Financial Disclosure: Dr. Tatsch is a meeting participant/lecturer for GE Healthcare. The authors of this article have indicated no other relevant relationships that could be perceived as a real or apparent conflict of interest. CME Credit: SNMMI is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing education for physicians. SNMMI designates each JNM continuing education article for a maximum of 2.0 AMA PRA Category 1 Credits. Physicians should claim only credit commensurate with the extent of their participation in the activity. For CE credit, participants can access this activity through the SNMMI Web site (http:// www.snmmi.org/ce_online) through August 2016.This article gives an update on nigrostriatal dopamine terminal imaging, with emphasis on SPECT performed with the presynaptic dopamine transporter (DAT) ligand 123 I-FP-CIT. The paper covers the rational use of this technique in the diagnostic work-up of patients with known or suspected parkinsonian syndromes. In detail, it addresses the impact of the method for the proof or exclusion of neurodegenerative parkinsonism, for its early and preclinical diagnosis, and for the evaluation of disease progression. The importance of normal DAT binding for differentiating symptomatic parkinsonism and relevant tremor syndromes from neurodegeneration is highlighted. Particularly emphasized is the role of DAT SPECT for diagnosing Lewy body dementia and its separation from Alzheimer dementia. Finally, some remarks deal with the economic aspects of the use of these imaging techniques in the clinical setting.

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SPECT study with I-123-Ioflupane (DaTSCAN) in patients with essential tremor. Is there any correlation with Parkinson’s disease?

Cited by 44 publications

References 34 publications

Neuroimaging essentials in essential tremor: A systematic review

Neuroimaging essentials in essential tremor: A systematic review

Neuroimaging of Parkinson's disease: Expanding views

Nigrostriatal Dopamine Terminal Imaging with Dopamine Transporter SPECT: An Update

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