SPECT/PET Imaging with Technetium, Gallium, Copper, and Other Metallic Radionuclides

Alberto, Roger; Braband, Henrik

doi:10.1016/b978-0-08-097774-4.00331-4

Cited by 13 publications

(13 citation statements)

References 522 publications

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“…A long series of unstable isotopes exists, including 99 Tc and its nuclear isomer 99m Tc. The metastable 99m Tc is essential in nuclear medicine for imaging, , whereas 99 Tc comes from nuclear waste in bulk amounts as pertechnetate ([ 99 TcO 4 ] − ). The 99 Tc radionuclide is a weak β – emitter ( E max = 293 keV) with a long half-life (∼2 × 10 5 y) .…”

Section: Introductionmentioning

confidence: 99%

Exploring the Coordination Chemistry of N₂ with Technetium PNP Pincer-Type Complexes

et al. 2021

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Dinitrogen (N 2 ) complexes of technetium ( 99 Tc) are rare, and only two examples have been reported. To complement this important class of complexes also for 99 Tc, two different pincer-type complexes of 99 Tc were studied to assess their abilities for coordinating dinitrogen. The reactions of the 99 Tc III complex [ 99 TcCl 3 (PPh 3 ) 2 (NCCH 3 )] with the pincer ligands PNP tBu and Pyr PNP tBu respectively gave [ 99 Tc(PNP tBu )Cl 2 ] and [ 99 Tc( Pyr PNP tBu )Cl 3 ], the first structurally characterized 99 Tc complexes with mer-coordinated pincer ligands. Reductions with [Co(Cp*) 2 ] under N 2 gave the mononuclear bis-dinitrogen complex [ 99 Tc I (PNP tBu )(N 2 ) 2 ] and the dinuclear complex [ 99 Tc I ( Pyr PNP tBu )(N 2 )Cl] 2 (μ-N 2 ) with both a bridging and a terminal N 2 ligand. Spectroscopy and crystal structures confirm their identities. The complexes are stable under a dinitrogen atmosphere, and the N 2 ligands are tightly bound. The results for the complexes with the PNP tBu pincer allow a comparison to its rhenium homologue, which has recently been shown to split the N 2 ligand with the formation of a nitrido complex.

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Section: Introductionmentioning

confidence: 99%

Exploring the Coordination Chemistry of N₂ with Technetium PNP Pincer-Type Complexes

et al. 2021

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“…[9] This is as ignificant gap in our knowledge because rhenium-oxoc orroles are not only potentially important as catalysts, [10] they may also find applicationsi nr adioimaging and -therapy. [11] Furthermore, an efficient route to rheniumc orroles may pave the way to an analogousr oute to technetium corroles. [12] We were delighted to discover that an oxidative metalation protocol, akin to the one used for Os corroles, [4] 10 ]i nr efluxing decalin in af ew hours and in yields of 62-84 %(Scheme 1).…”

mentioning

confidence: 99%

Metal–Ligand Misfits: Facile Access to Rhenium–Oxo Corroles by Oxidative Metalation

Einrem

Gagnon

Alemayehu

et al. 2015

Chemistry A European J

109

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With the exception of a single accidental synthesis, rhenium corroles are unknown, but of great interest as catalysts and potential radiopharmaceuticals. Oxidative metalation of meso-triarylcorroles with [Re2 (CO)10 ] in refluxing decalin has provided a facile and relatively high-yielding route to rhenium(V)-oxo corroles. The complexes synthesized could all be fully characterized by single-crystal X-ray structure analyses.

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“…Technetium-99m (t 1/2 = 6.01 h; IT = 100%) is the most common radionuclide used to develop SPECT radiotracers. 63 In contrast to many other radionuclides described here, the chemistry of 99m Tc is highly diverse. Technetium lies in group 7B of the periodic table, underneath manganese and, as such, exhibits a rich redox chemistry.…”

Section: Technetium-99m Radiolabeled Antibodiesmentioning

confidence: 91%

“…A unique feature of 99m Tc radiochemistry is the concept FIGURE 6 Chemical structures of 99m Tc chelates that incorporate different " 99m Tc-cores" of utilizing different " 99m Tc-cores" with the 3 most common being { 99m Tc=O}, { 99m TcO 3 }, and { 99m Tc(CO) 3 } ( Figure 6). 63 During the mid-1990s to mid-2000s, a number of 99m Tc-mAbs received market approval. 2 For example, 99m Tc-nofetumomab merpentan (Verluma ® ) is a mouse mAb Fab fragment attached to a merpentan chelate and used for imaging the pan-carcinoma glycoprotein antigen EpCAM and/or CD20/MS4A1 in cancers of the lung, gastrointestinal tract, breast, ovary, pancreas, cervix, kidney, and bladder.…”

Section: Technetium-99m Radiolabeled Antibodiesmentioning

confidence: 99%

Chemical aspects of metal ion chelation in the synthesis and application antibody‐based radiotracers

Boros

Holland

2018

Labelled Comp Radiopharmac

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Radiometals are becoming increasingly accessible and are utilized frequently in the design of radiotracers for imaging and therapy. Nuclear properties ranging from the emission of γ-rays and β -particles (imaging) to Auger electron and β and α-particles (therapy) in combination with long half-lives are ideally matched with the relatively long biological half-life of monoclonal antibodies in vivo. Radiometal labeling of antibodies requires the incorporation of a metal chelate onto the monoclonal antibody. This chelate must coordinate the metal under mild conditions required for the handling of antibodies, as well as provide high kinetic, thermodynamic, and metabolic stability once the metal ion is coordinated to prevent release of the radionuclide before the target site is reached in vivo. Herein, we review the role of different radiometals that have found applications of the design of radiolabeled antibodies for imaging and radioimmunotherapy. Each radionuclide is described regarding its nuclear synthesis, coordinative preference, and radiolabeling properties with commonly used and novel chelates, as well as examples of their preclinical and clinical applications. An overview of recent trends in antibody-based radiopharmaceuticals is provided to spur continued development of the chemistry and application of radiometals for imaging and therapy.

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SPECT/PET Imaging with Technetium, Gallium, Copper, and Other Metallic Radionuclides

Cited by 13 publications

References 522 publications

Exploring the Coordination Chemistry of N₂ with Technetium PNP Pincer-Type Complexes

Exploring the Coordination Chemistry of N₂ with Technetium PNP Pincer-Type Complexes

Metal–Ligand Misfits: Facile Access to Rhenium–Oxo Corroles by Oxidative Metalation

Chemical aspects of metal ion chelation in the synthesis and application antibody‐based radiotracers

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SPECT/PET Imaging with Technetium, Gallium, Copper, and Other Metallic Radionuclides

Cited by 13 publications

References 522 publications

Exploring the Coordination Chemistry of N2 with Technetium PNP Pincer-Type Complexes

Exploring the Coordination Chemistry of N2 with Technetium PNP Pincer-Type Complexes

Metal–Ligand Misfits: Facile Access to Rhenium–Oxo Corroles by Oxidative Metalation

Chemical aspects of metal ion chelation in the synthesis and application antibody‐based radiotracers

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Product

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Exploring the Coordination Chemistry of N₂ with Technetium PNP Pincer-Type Complexes

Exploring the Coordination Chemistry of N₂ with Technetium PNP Pincer-Type Complexes