SPECT patterns in probable Alzheimer's disease

Müller, Horst; Möller, H.-J.; Stippel, A.; Fric, Milan; Grünwald, Frank; Laux, Georg; Klemm, E.; Biersack, H. J.

doi:10.1007/s004060050086

Cited by 17 publications

(19 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the same time, the medical community accepted that AD initially affects mainly the posterior regions and then with time shifts -visible with SPECT imaging -to affect the anterior association regions. For example, in some recent studies it was still noticed that in AD 'a wide variety of patterns was found' [7] or that 'there are no individual patterns which can be considered "typical"' [34]. Our results contradict these data.…”

Section: Discussioncontrasting

confidence: 57%

See 1 more Smart Citation

Is There a Typical Pattern of Brain SPECT Imaging in Alzheimer’s Disease?

Steinling

Defebvre

Duhamel

et al. 2001

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

The identification of new nosological forms such as Lewy body disease (LBD) requires a re-evaluation of the patterns observed in brain functional imaging in the various forms of dementia. We studied 60 demented patients, divided into three groups and fulfilling the clinical criteria for Alzheimer’s disease (AD), LBD and frontotemporal dementia (FTD), using Tc-HMPAO and a brain-dedicated SPECT system. After normalisation we applied a cut-off at two levels according to previously established criteria. We reaffirmed the already established data concerning FTD (mainly a bilateral frontal decrease) and for LBD (a severe diffuse decrease in the frontal regions and also in the posterior association cortex). In contrast, the decrease in AD was strictly limited to the parieto-occipital cortex, irrespective of the severity of the cognitive decline. We hypothesise that the major simplification concerning the pattern observed in AD can be explained by the fact that patients suffering from LBD have previously been included in the groups of AD patients.

show abstract

Section: Discussioncontrasting

confidence: 57%

“…Later, and especially after the first publication by Derouesné et al [2], ideas changed, and the dominant concept became that of the heterogeneity of all aspects of AD, including functional imaging [3][4][5][6][7]. This abundance of observable aspects in AD casts doubt on the real practical uses of functional imaging as a diagnostic aid.…”

Section: Introductionmentioning

confidence: 99%

Is There a Typical Pattern of Brain SPECT Imaging in Alzheimer’s Disease?

Steinling

Defebvre

Duhamel

et al. 2001

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…Neuropsychological studies revealed that DLB patients have prominent functional deficits in attention, visual perception, working memory, and frontal executive function compared to AD [65-67]. The occipital dominant impairment observed in DLB patients could explain the deficits in visual attention and visual perception because visual information flows from the occipital cortex to higher cognitive areas such as the VAN and DAN [68]. In support of this argument, there is a previous finding that the administration of AchEI, which increases Ach in the brain, recovered global cognitive function and occipital hypoperfusion in DLB patients [69, 70].…”

Section: Discussionmentioning

confidence: 99%

EEG Resting-State Networks in Dementia with Lewy Bodies Associated with Clinical Symptoms

et al. 2019

View full text Add to dashboard Cite

Background: Dementia with Lewy bodies (DLB) is characterized by progressive cognitive decline, fluctuating cognition, visual hallucinations, rapid eye movement sleep behavior disorder, and parkinsonism. DLB is the second most common type of degenerative dementia of all dementia cases. However, DLB, particularly in the early stage, is underdiagnosed and sometimes misdiagnosed with other types of dementia. Thus, it is of great interest investigating neurophysiological markers of DLB. Method: We introduced exact low-resolution brain electromagnetic tomography (eLORETA)-independent component analysis (ICA) to assess activities of 5 electroencephalography (EEG) resting-state networks (RSNs) in 41 drug-free DLB patients. Results: Compared to 80 healthy controls, DLB patients had significantly decreased activities in occipital visual and sensorimotor networks, where DLB patients and healthy controls showed no age dependences in all EEG-RSN activities. Also, we found correlations between all EEG-RSN activities and DLB symptoms. Specifically, decreased occipital α activity showed correlations with worse brain functions related to attention/concentration, visuospatial discrimination, and global cognition. Enhanced visual perception network activity correlated with milder levels of depression and anxiety. Enhanced self-referential network activity correlated with milder levels of depression. Enhanced memory perception network activity correlated with better semantic memory, visuospatial discrimination function, and global cognitive function as well as with severer visual hallucination. In addition, decreased sensorimotor network activity correlated with a better semantic memory. Conclusion: These results indicate that eLORETA-ICA can detect EEG-RSN activity alterations in DLB related to symptoms. Therefore, eLORETA-ICA with EEG data can be a useful noninvasive tool for sensitive detection of EEG-RSN activity changes characteristic of DLB and for understanding the neurophysiological mechanisms underlying this disease.

show abstract

“…Z score of 2 or more was used as a cut-off value to determine the abnormal pixels. First, a template region-of-interest (ROI) map of stereotactic extraction estimation (SEE) (Nihon Medi-Physics Co Ltd, Tokyo, Japan) [29] was adopted based on Talairach's brain atlas [25] and four regions of the superior and inferior parietal lobule, as well as of the precuneus and posterior cingulate gyrus were selected, where significant hypoperfusion has been reported in AD [7][8][9][10][11]. Next, the number of pixels showing abnormal Z scores in selected regions was summed.…”

Section: Development Of a Fully Automatic Diagnostic Systemmentioning

confidence: 99%

“…Brain perfusion single-photon emission computed tomography (SPECT) is used for to diagnose AD, and characteristically shows regional hypoperfusion in the parietotemporal lobe, precuneus and posterior cingulate gyrus [7][8][9][10][11]. Although the results of brain perfusion SPECT are usually evaluated by visual inspection, its performance and reproducibility largely depend on the physician's clinical experience.…”

Section: Introductionmentioning

confidence: 99%