SPECT neuroimaging in schizophrenia with religious delusions

Puri, Basant K.; Lekh, Sudesh K.; Nijran, K. S.; Bagary, M.; Richardson, Alexandra J.

doi:10.1016/s0167-8760(00)00159-8

Cited by 33 publications

(23 citation statements)

References 18 publications

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“…While a majority of studies pointed towards a role of the temporolimbic cortex in the development of delusions, individual studies reported inconsistent alterations with respect to the increase or decrease in regional cerebral blood flow and the involvement of further brain areas such as the prefrontal and parietal cortex [5,8]. With respect to alterations of regional cerebral blood flow and the manifestation of delusions, several studies pointed to an involvement of the left temporal and frontal cortex as well as the ventral striatum [9,10,11,12]. For example, the degree of suspiciousness (a subscale of the Brief Psychiatric Rating Scale) was associated in one study with altered regional cerebral blood flow in the left inferior temporal gyrus [13].…”

Section: Cortical and Subcortical Alterations And Delusionsmentioning

confidence: 99%

Neurobiological Correlates of Delusion: Beyond the Salience Attribution Hypothesis

et al. 2012

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Dopamine dysfunction is a mainstay of theories aimed to explain the neurobiological correlates of schizophrenia symptoms, particularly positive symptoms such as delusions and passivity phenomena. Based on studies revealing dopamine dysfunction in addiction research, it has been suggested that phasic or chaotic firing of dopaminergic neurons projecting to the (ventral) striatum attribute salience to otherwise irrelevant stimuli and thus contribute to delusional mood and delusion formation. Indeed, several neuroimaging studies revealed that neuronal encoding of usually irrelevant versus relevant stimuli is blunted in unmedicated schizophrenia patients, suggesting that some stimuli that are irrelevant for healthy controls acquire increased salience for psychotic patients. However, salience attribution per se may not suffice to explain anxieties and feelings of threat that often accompany paranoid ideation. Here, we suggest that beyond ventral striatal dysfunction, dopaminergic dysregulation in limbic areas such as the amygdala in interaction with prefrontal and temporal cortex may contribute to the formation of delusions and negative symptoms. Neuroleptic medication, on the other hand, appears to interfere with anticipation of reward in the ventral striatum and can thus contribute to secondary negative symptoms such as apathy and avolition.

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Section: Cortical and Subcortical Alterations And Delusionsmentioning

confidence: 99%

Neurobiological Correlates of Delusion: Beyond the Salience Attribution Hypothesis

et al. 2012

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“…However, attempts to locate the origin of religious delusions in the brain have not revealed findings that are consistent with neuroimaging research described above. The only study to date, to my knowledge, suggested that religious delusions result from a combination of over-activity of the left temporal lobe and under-activity of the left occipital lobe (Puri et al, 2001). Thus, until more research is done, the neuroanatomical origin of religious delusions remains uncertain.…”

Section: Religious Delusionsmentioning

confidence: 96%

Religião, espiritualidade e transtornos psicóticos

Koenig¹

2007

Rev. psiquiatr. clín.

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Background: Religion is often included in the beliefs and experiences of psychotic patients, and therefore becomes the target of psychiatric interventions. Objectives: This article examines religious beliefs and activities among nonpsychotic persons in the United States, Brazil and other areas of the world; discusses historical factors contributing to the wall of separation between religion and psychiatry today; reviews studies on the prevalence of religious delusions in patients with schizophrenia, bipolar disorder, and other severe mental disorders; discusses how clinicians can distinguish pathological from non-pathological religious involvement; explores how persons with severe mental illness use non-pathological religious beliefs to cope with their disorder; examines the effects of religious involvement on disease course, psychotic exacerbations, and hospitalization; and describes religious or spiritual interventions that may assist in treatment. Methods: Literature review. Findings: While about one-third of psychoses have religious delusions, not all religious experiences are psychotic. In fact, they may even have positive effects on the course of severe mental illness, forcing clinicians to make a decision on whether to treat religious beliefs and discourage religious experiences, or to support them. Conclusions: Clinicians should understand the negative and positive roles that religion plays in those with psychotic disorders.

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“…A recent study, using human brain functional imaging technology, reported an association between hyper-activation of the left temporal lobe with occurrence of religious delusions in a single case study of Schizophrenia (Puri et al, 2001).…”

Section: Early and Influential Studiesmentioning

confidence: 99%

From Brain Imaging Religious Experience to Explaining Religion: A Critique

Azari

Slors

2007

Archive for the Psychology of Religion

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Please be advised that this information was generated on 2018-05-09 and may be subject to change. AbstractRecent functional neuroimaging data, acquired in studies of religious experience, have been used to explain and justify religion and its origins. In this paper, we critique the move from describing brain activity associated with self-reported religious states, to explaining why there is religion at all. Toward that end, first we review recent neuroimaging findings on religious experience, and show how those results do not necessarily support a popular notion that religion has a primitive evolutionary origin. Importantly, we call into question an assumption-key to that account of religionconcerning a conceptual relation between 'religion' and 'religious experience' . Th en, we examine the conditions that must be met in order to explain religion on the basis of brain imaging findings. Moreover, we list principled reasons to be sceptical of explanations of religion in terms of the neural underpinnings of experiences. We conclude that the data from neuroimaging studies are not suited for an explanation of religion.

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SPECT neuroimaging in schizophrenia with religious delusions

Cited by 33 publications

References 18 publications

Neurobiological Correlates of Delusion: Beyond the Salience Attribution Hypothesis

Neurobiological Correlates of Delusion: Beyond the Salience Attribution Hypothesis

Religião, espiritualidade e transtornos psicóticos

From Brain Imaging Religious Experience to Explaining Religion: A Critique

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