SPECT myocardial blood flow quantitation toward clinical use: a comparative study with 13N-Ammonia PET myocardial blood flow quantitation

Abstract

Quantitation with SPECT technologies can be accurate to measure myocardial blood flow as PET quantitation while comprehensive imaging factors of SPECT to derive the variability between these two approaches were fully addressed and corrected.

Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation

“…The feasibility of this approach has been demonstrated in a large animal model, 155 but at this time SPECT MBF and MFR measurements in humans are very new. While the results have been very encouraging, investigations with both conventional rotating systems 156,157 and non-rotating cardiac cameras 15,17,158,159 have been limited to single-center feasibility studies. While the benefits of PET-based MBF/MFR are clear, [160][161][162][163] no published study has currently evaluated the incremental diagnostic and prognostic value of SPECT MBF and MFR measurements; more investigations are ongoing in this area.…”

Clinical Applications of Coronary Flow Reserve in Patients with Coronary Artery Disease

“…CFR is now available noninvasively on multimodalities such as dynamic CT or MRI perfusion scan (15,16), SPECT (17), and flow velocity on MRI (18). The cold pressor test (CPT) is another method for stress testing in addition to adenosine stress.…”

Novel SPECT Technologies and Approaches in Cardiac Imaging

“…The authors also demonstrated that quantitative flow results are potentially less accurate if these physical corrections are not performed. In another recent study from the same group, 28 patients were studied with conventional SPECT/ CT, and the flow-dependent extraction fraction relationship was determined by the fitting of the SPECT quantification results to the 13N-ammonia results [75]. With this approach, very good correlations were obtained for global and regional MBF and MFR by technetium (99mTc) sestamibi SPECT and 13N-ammonia PET (R2=0.71–0.92).…”

“…The ROC curves comparing the ML algorithm versus expert visual analysis for the detection of obstructive coronary artery disease. With kind permission of Springer: Journal of Nuclear Cardiology, Improved accuracy of myocardial perfusion SPECT for detection of coronary artery disease by machine learning in a large population, Volume 20, 2013, pp 553–562, Arsanjani et al [75]. …”