SPECT in Alzheimer's disease:features associated with bilateral parietotemporal hypoperfusion

Abstract

These findings may be useful in the clinical setting and point to heterogeneity of AD according to age at onset.

Selective Hypoperfusion of Anterior Cingulate Gyrus in Depressed AD Patients: A Brain SPECT Finding by Statistical Parametric Mapping

“…Decreased perfusion over the parieto-temporal region in SPECT images has been well demonstrated in AD patients [8,9], and it has become a part of the diagnostic tool in clinical practice. Plenty of SPECT and positron emission tomography (PET) studies discuss the perfusion differences in AD patients with or without delusion, apathy, or other psychotic symptoms [10][11][12][13][14][15][16][17][18][19][20]; yet only a few studies mention the differences between depressed and nondepressed AD patients [10][11][12][13][14][15].…”

PET e SPECT cerebrais na avaliação dos estados demenciais

“…Duração dos sintomas, tipo de câmara de cintilação ou mesmo radiofármaco empregado não influenciaram os resultados em qualquer sentido. 13 Porém, qual a relevância da indicação de métodos funcionais mais sensíveis de neuroimagem em pacientes com esse tipo de desordem degenerativa cerebral? Mais de duas décadas atrás, não existiam perspectivas de tratamento medicamentoso para esse tipo de desordem orgânica.…”

Neuroimaging in Dementia and Other Amnestic Disorders

“…However, not all patients with AD have Bilateral parietotemporal hypoperfusion. In a study conducted by our group in 104 patients fulfilling NINCDS-ADRDA criteria for probable AD, bilateral parietotemporal hypoperfusion was more frequent in patients with severe AD, in those with early onset of the symptoms, and in men (Nitrini et al, 2000).…”