SPECT/CT imaging of temperature-sensitive liposomes for MR-image guided drug delivery with high intensity focused ultrasound

Smet, Mariska de; Langereis, Sander; Bosch, Sandra van den; Bitter, Katrin; Hijnen, Nicole M; Heijman, Edwin; Grüll, Holger

doi:10.1016/j.jconrel.2013.04.005

Cited by 74 publications

(56 citation statements)

References 55 publications

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“…[1][2][3] The modalities of MI technologies are currently used in optical imaging, 4 ultrasound, 5 magnetic resonance imaging, 6 computed tomography (CT), 7 and positron-emission tomography. 8 As one of the most commonly used MI technologies, CT offers more spatial anatomic details with high resolution than other imaging modalities.…”

Section: Introductionmentioning

confidence: 99%

Engineering iodine-doped carbon dots as dual-modal probes for fluorescence and X-ray CT imaging

Zhang¹,

Ju²,

Zhang³

et al. 2015

IJN

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X-ray computed tomography (CT) is the most commonly used imaging technique for noninvasive diagnosis of disease. In order to improve tissue specificity and prevent adverse effects, we report the design and synthesis of iodine-doped carbon dots (I-doped CDs) as efficient CT contrast agents and fluorescence probe by a facile bottom-up hydrothermal carbonization process. The as-prepared I-doped CDs are monodispersed spherical nanoparticles (a diameter of ~2.7 nm) with favorable dispersibility and colloidal stability in water. The aqueous solution of I-doped CDs showed wavelength-dependent excitation and stable photoluminescence similar to traditional carbon quantum dots. Importantly, I-doped CDs displayed superior X-ray attenuation properties in vitro and excellent biocompatibility. After intravenous injection, I-doped CDs were distributed throughout the body and excreted by renal clearance. These findings validated that I-doped CDs with high X-ray attenuation potency and favorable photoluminescence show great promise for biomedical research and disease diagnosis.

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Section: Introductionmentioning

confidence: 99%

Engineering iodine-doped carbon dots as dual-modal probes for fluorescence and X-ray CT imaging

Zhang¹,

Ju²,

Zhang³

et al. 2015

IJN

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“…The types of stimuli include light, 39 pH, 13,14 enzymatic degradation 40 and gain or loss of heat. 12,41,42 Previous approaches to generate pH-sensitive liposomes using CHEM in conjunction with various lipids have been reported. At physiological pH, the lipid combinations such as egg PC/dimethyldioctadecylammonium bromide/ CHEM, 18 egg PC/oleyl alcohol/CHEM 19 and diolein/CHEM 25 conferred net negative charges to liposomal particles and maintained a stable bilayer.…”

mentioning

confidence: 99%

Formulation, characterization and tissue distribution of a novel pH-sensitive long-circulating liposome-based theranostic suitable for molecular imaging and drug delivery

Duan

Wei²,

Petryk³

et al. 2016

IJN

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“…99 This strategy allows a higher amount of contrast agent and drug to be encapsulated whilst avoiding osmotic effects. 86 The second strategy is to coencapsulate both drug and contrast agent in the same TSL, [54][55][56][57]82,83,97 which limits the amount of both components in each TSL. Nevertheless, for both strategies, it has to be ensured that the temperature-dependent drug release rate and MRI signal change are correlated.…”

Section: Applicationsmentioning

confidence: 99%

“…Hijnen et al addressed this concern in a rat model, but could not detect dissociation of gadolinium-DTPA in high intensity focused ultrasound ablation therapy. 100 De Smet et al investigated the blood kinetics and biodistribution of 111 In-labeled TTSL with coencapsulated doxorubicin and gadolinium-(HPDO 3 A)(H 2 O) in Fisher rats, 57 and found significant clearance with #0.3% of the injected dose in all analyzed organs one month after injection. Nevertheless, before application in humans, further investigation of the risks associated with this strategy seems necessary.…”

Section: Applicationsmentioning

confidence: 99%

“…53 A traditional temperature-sensitive liposome (TTSL) formulation with coencapsulated doxorubicin and a gadolinium-based contrast agent for MRI-guided delivery of doxorubicin is currently under investigation. [54][55][56][57] The TTSL formulation has been used in these studies because of its higher stability when compared with lysolipidcontaining low temperature-sensitive liposome (LTSL) formulations. 54 …”

mentioning

confidence: 99%

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Thermosensitive liposomal drug delivery systems: state of the art review

Kneidl¹,

Peller²,

Winter³

et al. 2014

IJN

145

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Thermosensitive liposomes are a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like PEGylated liposomal doxorubicin. Up to March 2014, the Web of Science listed 371 original papers in this field, with 45 in 2013 alone. Several formulations have been developed since 1978, with lysolipid-containing, low temperature-sensitive liposomes currently under clinical investigation. This review summarizes the historical development and effects of particular phospholipids and surfactants on the biophysical properties and in vivo efficacy of thermosensitive liposome formulations. Further, treatment strategies for solid tumors are discussed. Here we focus on temperature-triggered intravascular and interstitial drug release. Drug delivery guided by magnetic resonance imaging further adds the possibility of performing online monitoring of a heating focus to calculate locally released drug concentrations and to externally control drug release by steering the heating volume and power. The combination of external targeting with thermosensitive liposomes and magnetic resonance-guided drug delivery will be the unique characteristic of this nanotechnology approach in medicine.

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SPECT/CT imaging of temperature-sensitive liposomes for MR-image guided drug delivery with high intensity focused ultrasound

Cited by 74 publications

References 55 publications

Engineering iodine-doped carbon dots as dual-modal probes for fluorescence and X-ray CT imaging

Engineering iodine-doped carbon dots as dual-modal probes for fluorescence and X-ray CT imaging

Formulation, characterization and tissue distribution of a novel pH-sensitive long-circulating liposome-based theranostic suitable for molecular imaging and drug delivery

Thermosensitive liposomal drug delivery systems: state of the art review

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