SPECT/CT Imaging of Mycobacterium tuberculosis Infection with [125I]anti-C3d mAb

Foss, Catherine A.; Kulik, Liudmila; Ordoñez, Alvaro A.; Jain, Sanjay; Holers, V. Michael; Thurman, Joshua M.; Pomper, Martin G.

doi:10.1007/s11307-018-1228-5

Cited by 20 publications

(12 citation statements)

References 52 publications

(57 reference statements)

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“…Most cameras produce 2D images, although some can perform tomographic 3D reconstructions. Foss et al [ 87 ] have designed a monoclonal antibody mAb 3d29 that can be used to detect and localize areas of infection with M. tuberculosis non-invasively, on SPECT, 24 h after radiotracer injection.…”

Section: Imaging Methods In Tuberculosismentioning

confidence: 99%

Tuberculosis conundrum - current and future scenarios: A proposed comprehensive approach combining laboratory, imaging, and computing advances

Merchant¹,

Shaikh²,

Nadkarni³

2022

WJR

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Tuberculosis (TB) remains a global threat, with the rise of multiple and extensively drug resistant TB posing additional challenges. The International health community has set various 5-yearly targets for TB elimination: mathematical modelling suggests that a 2050 target is feasible with a strategy combining better diagnostics, drugs, and vaccines to detect and treat both latent and active infection. The availability of rapid and highly sensitive diagnostic tools (Gene-Xpert, TB-Quick) will vastly facilitate population-level identification of TB (including rifampicin resistance and through it, multi-drug-resistant TB). Basic-research advances have illuminated molecular mechanisms in TB, including the protective role of Vitamin D. Also, Mycobacterium tuberculosis impairs the host immune response through epigenetic mechanisms (histone-binding modulation). Imaging will continue to be key, both for initial diagnosis and follow-up. We discuss advances in multiple imaging modalities to evaluate TB tissue changes, such as molecular imaging techniques (including pathogen-specific positron emission tomography imaging agents), non-invasive temporal monitoring, and computing enhancements to improve data acquisition and reduce scan times. Big data analysis and Artificial Intelligence (AI) algorithms, notably in the AI sub-field called “Deep Learning”, can potentially increase the speed and accuracy of diagnosis. Additionally, Federated learning makes multi-institutional/multi-city AI-based collaborations possible without sharing identifiable patient data. More powerful hardware designs - e.g. , Edge and Quantum Computing- will facilitate the role of computing applications in TB. However, “Artificial Intelligence needs real Intelligence to guide it!” To have maximal impact, AI must use a holistic approach that incorporates time tested human wisdom gained over decades from the full gamut of TB, i.e. , key imaging and clinical parameters, including prognostic indicators, plus bacterial and epidemiologic data. We propose a similar holistic approach at the level of national/international policy formulation and implementation, to enable effective culmination of TB’s endgame, summarizing it with the acronym “TB - REVISITED”.

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Section: Imaging Methods In Tuberculosismentioning

confidence: 99%

Tuberculosis conundrum - current and future scenarios: A proposed comprehensive approach combining laboratory, imaging, and computing advances

Merchant¹,

Shaikh²,

Nadkarni³

2022

WJR

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“…A potential future methodology not yet in clinical practice would be to combine non-invasive imaging methods with a complement specific probe, e.g., a neo-epitope specific antibody coupled to a tracer. This method has been applied to antibodies specific for the C3 activation products C3d,g, with a recent example of an animal model of tuberculosis infection (22).…”

Section: Methodsmentioning

confidence: 99%

Current and Future Approaches for Monitoring Responses to Anti-complement Therapeutics

et al. 2019

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Aberrations in complement system functions have been identified as either direct or indirect pathophysiological mechanisms in many diseases and pathological conditions, such as infections, autoimmune diseases, inflammation, malignancies, and allogeneic transplantation. Currently available techniques to study complement include quantification of (a) individual complement components, (b) complement activation products, and (c) molecular mechanisms/function. An emerging area of major interest in translational studies aims to study and monitor patients on complement regulatory drugs for efficacy as well as adverse events. This area is progressing rapidly with several anti-complement therapeutics under development, in clinical trials, or already in clinical use. In this review, we summarized the appropriate indications, techniques, and interpretations of basic complement analyses, exemplified by a number of clinical disorders.

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“…Importantly, 89 Zr-SAC55 uptake at the infected site was also higher than that of the control non-specific antibody, thus demonstrating specificity and selectivity. Foss et al pursued the imaging of M. tuberculosis bacteria whose mostly intracellular location makes it difficult to detect it with the antibodies (44). The strategy used by the authors was to develop an antibody (mAb 3d29) which recognizes the tissue-bound terminal processing fragments iC3b and C3d of C3 complement but not the native circulating C3 or tissue-bound C3b.…”

Section: Imaging Bacterial Infections With Radiolabeled Antibiotics S...mentioning

confidence: 99%

Highlights of the Latest Developments in Radiopharmaceuticals for Infection Imaging and Future Perspectives

Dadachova

Rangel

2022

Front. Med.

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COVID-19 pandemic has heightened the interest toward diagnosis and treatment of infectious diseases. Nuclear medicine with its powerful scintigraphic, single photon emission computer tomography (SPECT) and positron emission tomography (PET) imaging modalities has always played an important role in diagnosis of infections and distinguishing them from the sterile inflammation. In addition to the clinically available radiopharmaceuticals there has been a decades-long effort to develop more specific imaging agents with some examples being radiolabeled antibiotics and antimicrobial peptides for bacterial imaging, radiolabeled anti-fungals for fungal infections imaging, radiolabeled pathogen-specific antibodies and molecular engineered constructs. In this opinion piece, we would like to discuss some examples of the work published in the last decade on developing nuclear imaging agents for bacterial, fungal, and viral infections in order to generate more interest among nuclear medicine community toward conducting clinical trials of these novel probes, as well as toward developing novel radiotracers for imaging infections.

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SPECT/CT Imaging of Mycobacterium tuberculosis Infection with [125I]anti-C3d mAb

Abstract: 3d29 can be used to detect and localize areas of infection with M. tuberculosis non-invasively by 24 h after radiotracer injection and with high contrast.

Cited by 20 publications

References 52 publications

Tuberculosis conundrum - current and future scenarios: A proposed comprehensive approach combining laboratory, imaging, and computing advances

Tuberculosis conundrum - current and future scenarios: A proposed comprehensive approach combining laboratory, imaging, and computing advances

Current and Future Approaches for Monitoring Responses to Anti-complement Therapeutics

Highlights of the Latest Developments in Radiopharmaceuticals for Infection Imaging and Future Perspectives

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