SPECT/CT hybrid imaging with <sup>111</sup>In‐pentetreotide in assessment of neuroendocrine tumours

Krausz, Yodphat; Keidar, Zohar; Kogan, Igor Yu.; Even-Sapir, Einat; Bar‐Shalom, Rachel; Engel, Ahuva; Rubinstein, Rina; Sachs, Jonathan; Bocher, Moshe; Agranovicz, Svetlana; Chisin, Roland; Israel, Ora

doi:10.1046/j.1365-2265.2003.01885.x

Cited by 176 publications

(80 citation statements)

References 36 publications

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“…These results agree with those from recent studies demonstrating that hardwarebased SPECT/ CT fusion improves diagnostic accuracy and subsequent management in roughly one third of patients studied compared to SPECT alone [14,16,18,21,22,32]. In particular, Even-Sapir et al [33] could demonstrate that skeletal SPECT/CT had significant bearing on diagnosis and further management of patients with non-oncological disease.…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Skeletal SPECT/CT of the peripheral extremities -interdisciplinary approach in orthopaedic disorders-first clinical results

Wuest

Kuwert

Grunewald³

et al. 2007

Open Medicine

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AbstractBone scintigraphy, although quite sensitive to detect skeletal lesions, has a comparatively low specificity. Hybrid-cameras combining single-photon emission computed tomography (SPECT) and spiral-CT offer the opportunity to correlate scintigraphic information with high-quality visualization of morphology in one session. This may lead to an improvement in diagnostic accuracy and anatomic lesion localization. We present 11 patients, who underwent SPECT/CT of the feet (n=10) and hands (n = 1). The examinations were performed due to pain in foot or hand with the following suspected clinical diagnoses: arthrosis (n=1); fracture (n=3); osteomyelitis (n=4); reflex dystrophia (n=1); and, pain of unclear origin (n=2). All patients underwent SPECT/CT hybrid imaging using a dual-headed SPECT camera integrated with a 2-slice spiral CT scanner in one gantry. SPECT, CT, and SPECT/CT were evaluated independently from each other with respect to main diagnosis, anatomic lesion localization, and detection of a possible additional diagnosis. SPECT/CT improved lesion localization in 8 of 11 patients (73%) in comparison to SPECT alone, and in 4 of 11 patients (36%) in comparison to CT alone. Diagnostic accuracy was improved in 4 of 11 patients (36%) in comparison to either SPECT or CT alone. In conclusion, skeletal SPECT/CT improves diagnostic accuracy and lesion localization of orthopedic disorders in the feet and hands. The obtained results encouraged extensive studies to further investigate the potential gain in diagnostic accuracy brought about by SPECT/spiral-CT hybrid imaging in orthopedic disorders of the peripheral extremities.

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Section: Discussionsupporting

confidence: 82%

“…The clinical impact of SPECT/low-dose CT has been investigated in tumors, but as yet not in orthopedic illness [14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Skeletal SPECT/CT of the peripheral extremities -interdisciplinary approach in orthopaedic disorders-first clinical results

Wuest

Kuwert

Grunewald³

et al. 2007

Open Medicine

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“…Of these, only 2 were 18 F-FDG PET-positive whereas 4 of the 18 F-FDG PET-positive tumors were larger than 3 cm. The overall sensitivities were relatively high in our study (89%, 52%, and 58% for SRS, 123 I-MIBG scintigraphy, and 18 F-FDG PET, respectively), compared with other studies (4), probably because of the addition of SPECT image acquisition and low-dose CT, which has been shown to increase the accuracy of detection and localization of pathologic foci (30,31). However, with the recent introduction of high-resolution CT cameras in combination with PET and g-cameras, the overall diagnostic sensitivity and accuracy are likely to increase further.…”

Section: Discussionmentioning

confidence: 53%

Functional Imaging of Neuroendocrine Tumors: A Head-to-Head Comparison of Somatostatin Receptor Scintigraphy, ¹²³I-MIBG Scintigraphy, and ¹⁸F-FDG PET

Binderup¹,

Knigge²,

Loft³

et al. 2010

J Nucl Med

256

166

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Functional techniques are playing a pivotal role in the imaging of cancer today. Our aim was to compare, on a head-to-head basis, 3 functional imaging techniques in patients with histologically verified neuroendocrine tumors: somatostatin receptor scintigraphy (SRS) with 111 In-diethylenetriaminepentaacetic acidoctreotide, scintigraphy with 123 I-metaiodobenzylguanidine (MIBG), and 18 F-FDG PET. Methods: Ninety-six prospectively enrolled patients with neuroendocrine tumors underwent SRS, 123 I-MIBG scintigraphy, and 18 F-FDG PET on average within 40 d. The functional images were fused with low-dose CT scans for anatomic localization, and the imaging results were compared with the proliferation index as determined by Ki67. Results: The overall sensitivity of SRS, 123 I-MIBG scintigraphy, and 18 F-FDG PET was 89%, 52%, and 58%, respectively. Of the 11 SRS-negative patients, 7 were 18 F-FDG PET-positive, of which 3 were also 123 I-MIBG scintigraphypositive, giving a combined overall sensitivity of 96%. SRS also exceeded 123 I-MIBG scintigraphy and 18 F-FDG PET based on the number of lesions detected (393, 185, and 225, respectively) and tumor subtypes. 123 I-MIBG scintigraphy was superior to 18 F-FDG PET for ileal neuroendocrine tumors, and 18 F-FDG PET was superior to 123 I-MIBG scintigraphy for pancreaticoduodenal neuroendocrine tumors. The sensitivity of 18 F-FDG PET (92%) exceeded that of both SRS (69%) and 123 I-MIBG scintigraphy (46%) for tumors with a proliferation index above 15%. Conclusion: The overall sensitivity of 123 I-MIBG scintigraphy and 18 F-FDG PET was low compared with SRS. However, for tumors with a high proliferation rate, 18 F-FDG PET had the highest sensitivity. The results indicate that, although SRS should still be the routine method, 18 F-FDG PET provides complementary diagnostic information and is of value for neuroendocrine tumor patients with negative SRS findings or a high proliferation index.

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“…The number of publications illustrating the added value of CT coregistration for SSTR planar imaging or SSTR SPECT is limited. The largest study to date evaluated SSTR SPECT/CT in 72 patients with various neuroendocrine tumors, including 45 carcinoid tumors, medullary thyroid carcinoma, or islet cell tumors (54). No additional information beyond that provided by planar imaging or SPECT was achieved for 48 patients, whereas SPECT/CT improved the localization of scintigraphic findings for 23 patients (32%) and changed clinical management for 14% of patients.…”

Section: Spect/ct In Neuroendocrine Tumorsmentioning

confidence: 99%

Spect/Ct

Buck¹,

Nekolla²,

Ziegler³

et al. 2008

J Nucl Med

281

149

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In view of the commercial success of integrated PET/CT scanners, there is an increasing interest in comparable SPECT/CT systems. SPECT in combination with CT enables a direct correlation of anatomic information and functional information, resulting in better localization and definition of scintigraphic findings. Besides anatomic referencing, the added value of CT coregistration is based on the attenuation correction capabilities of CT. The number of clinical studies is limited, but pilot studies have indicated a higher specificity and a significant reduction in indeterminate findings. The superiority of SPECT/CT over planar imaging or SPECT has been demonstrated in bone scintigraphy, somatostatin receptor scintigraphy, parathyroid scintigraphy, and adrenal gland scintigraphy. Also, rates of detection of sentinel nodes by biopsy can be increased with SPECT/CT. This review highlights recent technical developments in integrated SPECT/CT systems and summarizes the current literature on potential clinical uses and future directions for SPECT/CT in cardiac, neurologic, and oncologic applications.

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SPECT/CT hybrid imaging with ¹¹¹In‐pentetreotide in assessment of neuroendocrine tumours

Abstract: SPECT/CT affected the diagnostic interpretation of SRS in 32% of the patients and induced changes in management in 14% of the patients.

Cited by 176 publications

References 36 publications

Skeletal SPECT/CT of the peripheral extremities -interdisciplinary approach in orthopaedic disorders-first clinical results

Skeletal SPECT/CT of the peripheral extremities -interdisciplinary approach in orthopaedic disorders-first clinical results

Functional Imaging of Neuroendocrine Tumors: A Head-to-Head Comparison of Somatostatin Receptor Scintigraphy, ¹²³I-MIBG Scintigraphy, and ¹⁸F-FDG PET

Spect/Ct

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SPECT/CT hybrid imaging with 111In‐pentetreotide in assessment of neuroendocrine tumours

Abstract: SPECT/CT affected the diagnostic interpretation of SRS in 32% of the patients and induced changes in management in 14% of the patients.

Cited by 176 publications

References 36 publications

Skeletal SPECT/CT of the peripheral extremities -interdisciplinary approach in orthopaedic disorders-first clinical results

Skeletal SPECT/CT of the peripheral extremities -interdisciplinary approach in orthopaedic disorders-first clinical results

Functional Imaging of Neuroendocrine Tumors: A Head-to-Head Comparison of Somatostatin Receptor Scintigraphy, 123I-MIBG Scintigraphy, and 18F-FDG PET

Spect/Ct

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Product

Resources

About

SPECT/CT hybrid imaging with ¹¹¹In‐pentetreotide in assessment of neuroendocrine tumours

Functional Imaging of Neuroendocrine Tumors: A Head-to-Head Comparison of Somatostatin Receptor Scintigraphy, ¹²³I-MIBG Scintigraphy, and ¹⁸F-FDG PET