SPECT con ioflupano I-123 en la catalogación de pacientes con síndrome parkinsoniano y vasculopatía cerebral

Vicente, Ana María García; Cano, Julia; Castrejón, Á. Soriano; Delgado, C. Martínez; Rubio, P. Talavera; García, V.M. Poblete; Solís, S. Ruíz; Marina, S. Rodado; Romera, M. Cortés

doi:10.1016/s0212-6982(05)74184-7

Cited by 5 publications

(1 citation statement)

References 44 publications

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“…Regarding the vascular component involved in dementia, the role of nuclear medicine imaging in the diagnosis of vascular Parkinsonism (VP) or VaD has been addressed by only a few studies up to now and with non-definitive results. Some of these suggest normal 123 I-FP-CIT SPECT (Gerschlager et al, 2002 ; Lorberboym et al, 2004 ; García Vicente et al, 2005 ) in VP while others suggest reduced 123 I-FP-CIT binding as well as a lower mean asymmetry index than Parkinson’s disease (Zijlmans et al, 2007 ). In general more studies reported higher percentage of normal FP-CIT SPECT in VP patients (Bouwmans et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

123I-FP-CIT SPECT imaging in early diagnosis of dementia in patients with and without a vascular component

Garriga

Milà

Mir

et al. 2015

Front. Syst. Neurosci.

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Alzheimer’s disease (AD) and vascular dementia (VaD) are the most common cause of dementia. Cerebral ischemia is a major risk factor for development of dementia. 123I-FP-CIT SPECT (DaTScan) is a complementary tool in the differential diagnoses of patients with incomplete or uncertain Parkinsonism. Additional application of DaTScan enables the categorization of Parkinsonian disease with dementia (PDD), and its differentiation from pure AD, and may further contribute to change the therapeutic decision. The aim of this study was to analyze the vascular contribution towards dementia and mild cognitive impairment (MCI). We evaluated the utility of DaTScan for the early diagnosis of dementia in patients with and without a clinical vascular component, and the association between neuropsychological function, vascular component and dopaminergic function on DaTScan. One-hundred and five patients with MCI or the initial phases of dementia were studied prospectively. We developed an initial assessment using neurologic examination, blood tests, cognitive function tests, structural neuroimaging and DaTScan. The vascular component was later quantified in two ways: clinically, according to the Framingham Risk Score (FRS) and by structural neuroimaging using Wahlund Scale Total Score (WSTS). Early diagnosis of dementia was associated with an abnormal DaTScan. A significant association was found between a high WSTS and an abnormal DaTScan (p < 0.01). Mixed AD was the group with the highest vascular component, followed by the VaD group, while MCI and pure AD showed similar WSTS. No significant associations were found between neuropsychological impairment and DaTScan independently of associated vascular component. DaTScan seems to be a good tool to discriminate, in a first clinical assessment, patients with MCI from those with established dementia. There was bigger general vascular affectation observable in MRI or CT in patients with abnormal dopaminergic uptake seen on DaTScan.

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