Speckle-tracking strain echocardiography for detecting cardiac dyssynchrony in a canine model of dyssynchrony and heart failure

Abstract

Multiple echocardiographic criteria have been proposed to diagnose mechanical dyssynchrony in patients with heart failure without being validated against a model of cardiac dyssynchrony with heart failure. This study examines which of these methods can detect dyssynchrony in a canine model. Adult mongrel dogs underwent His-bundle ablation and right-ventricular pacing for 4 wk at either 110 bpm to induce dyssynchrony without heart failure (D group, n = 12) or 170 bpm to induce dyssynchrony with heart failure (DHF group, n = 9). To induce heart failure with narrow QRS, atria were paced at 190 bpm for 4 wk (HF group, n = 8). Tissue Doppler imaging (TDI) and two-dimensional echocardiography were performed at baseline and at end of study. Standard deviation of time to peak systolic velocity (color-coded TDI), time to peak S wave on pulse-wave TDI, time to peak radial and circumferential strain by speckle-tracking analysis (E(rr) and E(cc), respectively), and septal-to-posterior wall motion delay on M mode were obtained. In D group, only E(rr) and E(cc) were increased by dyssynchrony. In contrast, all the echocardiographic parameters of dyssynchrony appeared significantly augmented in the DHF group. Receiver-operator curve analysis showed good sensitivity of E(rr) (90%) and E(cc) (100%) to detected dyssynchrony without heart failure and excellent sensitivity and specificity of E(rr) and E(cc) to detect dyssynchrony with heart failure. Radial strain by speckle tracking is more accurate than TDI velocity to detect cardiac dyssynchrony in a canine model of dyssynchrony with or without heart failure.

High-frequency speckle tracking echocardiography in the assessment of left ventricular function and remodeling after murine myocardial infarction

“…To our knowledge, this is the first study to use a commercially available software package designed for small animal imaging to assess LV dyssynchrony in mice. Other studies have reported on LV dyssynchrony measured with a commercially available system in a canine model (1). We show that assessment of LV dyssynchrony with the current system is straightforward in mice although additional studies are required to assess the reliability of such data in more detail.…”

Left Ventricular Radial and Circumferential Wall Motion Analysis in Horses Using Strain, Strain Rate, and Displacement by 2D Speckle Tracking

“…24,25,[27][28][29] Derivation of these indices often requires some subjective assessment of which peaks to measure, a task that is not always objective and straightforward.…”

Echocardiographic strain and strain rate imaging — Clinical applications

“…The accuracy of speckle tracking 2D-strain echocardiography in the detection and quantification of cardiac dyssynchrony was validated experimentally in canine and sheep models [87,88]. In a canine model of dyssynchrony with and without heart failure, Arita et al found radial strain by speckle tracking to be more accurate than TDI velocity to detect cardiac dyssynchrony [88].…”