Speckle tracking echocardiography in systemic sclerosis: how far have we arrived and where can we go

Stronati, Giulia; Guerra, Federico; Gabrielli, Armando; Capucci, Alessandro

doi:10.1007/s10067-019-04774-0

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…The duplicate records (66) were excluded. Additionally, articles that did not provide useful data were excluded, including conference abstracts (119), reviews (19), basic research studies (1), case reports, editorials, notes and surveys (11), non-relevant records (30), as well as studies not written in English language (2). The remaining 48 studies were further evaluated based on fulltext articles, of which 17 articles were excluded due to insufficient data.…”

Section: Literature Search and Study Selectionmentioning

confidence: 99%

“…STE is also increasingly used to detect myocardial impairment in patients with SSc based on myocardial strain 10. However, results from studies are controversial, especially for the entire heart including ventricles and atria 11 12. The purpose of the present study was to conduct a meta-analysis to characterise cardiac involvement in patients with SSc compared with healthy controls using STE.…”

Section: Introductionmentioning

confidence: 99%

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Cardiac involvement assessment in systemic sclerosis using speckle tracking echocardiography: a systematic review and meta-analysis

Qiao

Wang

et al. 2023

BMJ Open

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ObjectivesCardiac involvement in patients with systemic sclerosis (SSc) is associated with poor prognosis. Early detection of myocardial impairment is essential for treatment. The present study aimed to systematically review the value of detecting subclinical myocardial impairment in SSc patients using myocardial strain obtained from speckle tracking echocardiography (STE).DesignA systematic review and meta-analysis.Data sourcesThe PubMed, Embase and Cochrane library databases were searched in the period from the earliest available indexing date to 30 September 2022.Eligibility criteria for selecting studiesStudies evaluating myocardial function in SSc patients comparison with healthy controls based on myocardial strain data obtained from STE were included.Data extraction and synthesisVentricle and atrium data on myocardial strain were extracted to assessing the mean difference (MD).ResultsA total of 31 studies were included in the analysis. Left ventricular global longitudinal strain (MD: −2.31, 95% CI −2.85 to –1.76), left ventricular global circumferential strain (MD: −2.93, 95% CI −4.02 to –1.84) and left ventricular global radial strain (MD: −3.80, 95% CI −5.83 to –1.77) was significantly lower in SSc patients than in healthy controls. Right ventricular global wall strain (MD: −2.75, 95% CI −3.25 to –2.25) was also decreased in SSc patients. STE revealed significant differences in several atrial parameters including left atrial reservoir strain (MD: −6.72, 95% CI −10.09 to –3.34) and left atrial conduit strain (MD: −3.26, 95% CI −6.50 to –0.03), as well as right atrial reservoir strain (MD: −7.37, 95% CI −11.20 to –3.53) and right atrial conduit strain (MD: −5.44, 95% CI −9.15 to –1.73). There were no differences in left atrial contractile strain (MD: −1.51, 95% CI −5.34 to 2.33).ConclusionSSc patients have a lower strain than healthy controls for the majority of STE parameters, indicating the presence of an impaired myocardium involving both the ventricle and atrium.

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Section: Literature Search and Study Selectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cardiac involvement assessment in systemic sclerosis using speckle tracking echocardiography: a systematic review and meta-analysis

Qiao

Wang

et al. 2023

BMJ Open

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“…STE is robust, reproducible and angle-independent and thus less liable to the intra-and interobserver variability. 14 This technique has shown a great promise in the evaluation of the cardiac performance in various clinical situations such as systemic lupus erythematosus, 15 rheumatic heart disease, 16 hereditary hemochromatosis, 17 systemic sclerosis, 18 and cancer chemotherapy. 19 To our knowledge, the current prospective study is the first to evaluate the effects of calcium and vitamin D supplementations on LV systolic functions in hypocalcemic infants using two-dimensional STE (2D-STE).…”

Section: Introductionmentioning

confidence: 99%

“…STE is robust, reproducible and angle‐independent and thus less liable to the intra‐ and inter‐observer variability 14 . This technique has shown a great promise in the evaluation of the cardiac performance in various clinical situations such as systemic lupus erythematosus, 15 rheumatic heart disease, 16 hereditary hemochromatosis, 17 systemic sclerosis, 18 and cancer chemotherapy 19 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of the left ventricular systolic strain in hypocalcemic infants with two‐dimensional speckle tracking echocardiography

et al. 2022

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Introduction: Speckle tracking echocardiography (STE) is a new emerging method for evaluation of the cardiac systolic performance. We characterized left ventricular (LV) systolic functions of hypocalcemic infants, and assessed the effects of calcium and vitamin D supplementations on LV systolic functions using two‐dimensional STE. Patients and Methods: A prospective controlled study was conducted in Mansoura University Children's Hospital, Egypt from 2015 to 2018 including 88 hypocalcemic infants (patient group) and 30 healthy controls. We subdivided the patient group into vitamin D deficiency group (n = 32) and normal vitamin D group (n = 56). All infants were investigated for serum phosphorus, alkaline phosphatase and 25‐hydroxy vitamin D levels. Both patients and controls were initially evaluated for LV systolic functions using two‐dimensional STE. After correction of hypocalcemia and vitamin D deficiency, reevaluation of LV systolic functions was done for the patient group. Results: LV systolic strains were lower in the patient group than controls (p < .001). After recovery of hypocalcemia of the patients, we reported significant improvement of strains and significant reductions of the end‐diastolic and end‐systolic volumes of the left ventricle (p < .001). Global longitudinal and circumferential strains were lower in patients with vitamin D deficiency than patients with normal vitamin D levels (p < .001). The LV systolic strain improved after correction of vitamin D deficiency and hypocalcemia (p < .001). Conclusion: Two‐dimensional STE could detect and follow up early LV systolic dysfunction in infants with hypocalcemia and vitamin D deficiency.

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Speckle-tracking global longitudinal strain predicts death and cardiovascular events in patients with systemic sclerosis

Stronati,

Guerra,

Benfaremo

et al. 2024

European Heart Journal Open

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Aims Albeit often asymptomatic, heart involvement in systemic sclerosis (SSc) represents a negative prognostic factor, accounting for nearly one-fourth of all deaths. Global longitudinal strain (GLS) is accurate in detecting heart involvement in patients with SSc and no overt cardiac disease and allows early detection and longitudinal monitoring, but its association with clinical endpoints has not been tested so far. The primary outcome was the association between left and right GLS and mortality for all causes. The secondary outcome was the association between left and right GLS and hospitalizations. Methods and results prospective longitudinal study enrolling all consecutive SSc patients without structural heart disease or previous cardiovascular event. A total of 164 patients were enrolled, of which 19 (11.5%) died during follow-up, while 48 (29.3%) were hospitalized. Both left and right ventricle GLS at enrolment were independently associated with an increased risk of death for all causes and hospitalizations. Patients with biventricular GLS impairment respectively had a 4.2-fold, 4.9-fold, and 13.9-fold increased risk of death when compared with patients with only LV, only RV, or no impairment (p<0.001). Incidence of hospitalization in patients with biventricular GLS impairment was nearly four times higher when compared with patients with only LV or only RV impairment, and nine times higher when compared with normal biventricular GLS (p<0.001). Conclusion Biventricular GLS is associated with an increased risk of death and hospitalization in patients with SSc during a median of 3-year follow-up, acting as a reliable and accurate prognostic tool in everyday practice.

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Speckle tracking echocardiography in systemic sclerosis: how far have we arrived and where can we go

Cited by 3 publications

References 6 publications

Cardiac involvement assessment in systemic sclerosis using speckle tracking echocardiography: a systematic review and meta-analysis

Cardiac involvement assessment in systemic sclerosis using speckle tracking echocardiography: a systematic review and meta-analysis

Evaluation of the left ventricular systolic strain in hypocalcemic infants with two‐dimensional speckle tracking echocardiography

Speckle-tracking global longitudinal strain predicts death and cardiovascular events in patients with systemic sclerosis

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