Background
Arrhythmia ablation with current techniques is not universally
successful. Inadequate ablation lesion formation may be responsible for some
arrhythmia recurrences. Peri-procedural visualization of ablation lesions
may identify inadequate lesions and gaps to guide further ablation and
reduce risk of arrhythmia recurrence.
Methods
This feasibility study assessed acute post-procedure ablation lesions
by MRI, and correlated these findings with clinical outcomes. Ten pediatric
patients who underwent ventricular tachycardia ablation were transferred
immediately post-ablation to a 1.5T MRI scanner and late gadolinium
enhancement (LGE) imaging was performed to characterize ablation lesions.
Immediate and mid-term arrhythmia recurrences were assessed.
Results
Patient characteristics include median age 14 years (1 – 18
years), median weight 52 kg (11 – 81kg), normal cardiac anatomy (n
= 6), d-transposition of great arteries post arterial switch repair
(n = 2), anomalous coronary artery origin post repair (n =
1), and cardiac rhabdomyoma (n = 1). All patients underwent
radiofrequency catheter ablation of ventricular arrhythmia with acute
procedural success. LGE was identified at the reported ablation site in 9/10
patients, all arrhythmia-free at median 7 months follow-up. LGE was not
visible in 1 patient who had recurrence of frequent premature ventricular
contractions within 2 hours, confirmed on Holter at 1 and 21 months
post-procedure.
Conclusions
Ventricular ablation lesion visibility by MRI in the acute
post-procedure setting is feasible. Lesions identifiable with MRI may
correlate with clinical outcomes. Acute MRI identification of gaps or
inadequate lesions may provide the unique temporal opportunity for
additional ablation therapy to decrease arrhythmia recurrence.