Specificity of noninvasive blood glucose monitoring with optical coherence tomography

Glucose monitoring technology has been used in the management of diabetes for three decades. Traditional devices use enzymatic methods to measure glucose concentration and provide point sample information. More recently continuous glucose monitoring devices have become available providing more detailed data on glucose excursions. In future applications the continuous glucose sensor may become a critical component of the closed loop insulin delivery system and, as such, must be selective, rapid, predictable and acceptable for continuous patient use. Many potential sensing modalities are being pursued including optical and transdermal techniques. This review aims to summarize existing technology, the methods for assessing glucose sensing devices and provide an overview of emergent sensing modalities.

show abstract

“…The OCT signal correlated well with laboratory glucose values ( r = 0.8-0.95) in individual subjects suggesting future potential [44].…”

Section: Optical Coherence Tomographymentioning

confidence: 72%

Glucose sensors: a review of current and emerging technology

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Methods based on fluorescence [7][8][9][10][11][12][13][14][15][16][17], near-infrared (NIR) and mid-infrared (mid-IR) spectroscopic [18][19][20][21][22][23][24][25][26], Raman spectroscopic [22,[27][28][29], photoacoustic [30,31], optical coherence tomography (OCT) [32][33][34][35][36], and other techniques are discussed in this chapter.…”

Section: Introductionmentioning

confidence: 99%

Sensing Glucose and Other Metabolites in Skin

Genina

Larin

Bashkatov

et al. 2012

Handbook of Biophotonics

Self Cite

View full text Add to dashboard Cite

The sections in this article are Introduction Light–Tissue Interaction Fluorescence Measurements IR Spectroscopy Photoacoustic Technique Raman Spectroscopy Occlusion Spectroscopy Reflectance Spectroscopy Polarimetric Technique OCT Technique Conclusion Acknowledgments

show abstract

“…This is achieved by generating slice images of three-dimensional objects [4]. Basically, optical coherence tomography (OCT) utilizes a low coherence Michelson interferometer to obtain high-resolution crosssectional imaging of biological tissues [5][6][7]. By using OCT, the human retinal inner structure, including the cellular tissue layer, has been digitized.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Performance of Spectral Domain Optical Doppler Tomography with High-speed Line Scanning CMOS Camera and Its Application to the Blood Flow Measurement in a Micro-tube

Park

Lee

Lim

et al. 2012

Journal of the Optical Society of Korea

View full text Add to dashboard Cite

In this study, the feasibility of spectral domain optical Doppler tomography for measuring blood flow characteristics in a micro-tube was demonstrated through several experiments. The use of an SD-ODT system in blood flow measurement can provide high resolution images (5 microns resolution). We prepared three capillary tubes to reveal the effect of different concentrations of hematocrit ratio (HR). One tube serves as the control. The two other tubes contained different concentrations of HR (5%, 25%). Three different capillary tube inlet flow velocities were tested in the present study. The Reynolds number (Re) which is based on the capillary tube inner diameter ranges from Re=6 to 48. We calculated a Doppler shift of the power spectrum of the temporal interference fringes with Kasai autocorrelation function to achieve the velocity profile of the flow. As a result, SD-ODT systems could not detect the cell depletion layer in the present study due to the limitation of spatial resolution. Nevertheless, these systems were proven to be capable of observing the RBCs of blood.

show abstract

Specificity of noninvasive blood glucose monitoring with optical coherence tomography

Cited by 23 publications

References 7 publications

Glucose sensors: a review of current and emerging technology

Glucose sensors: a review of current and emerging technology

Sensing Glucose and Other Metabolites in Skin

Investigation of the Performance of Spectral Domain Optical Doppler Tomography with High-speed Line Scanning CMOS Camera and Its Application to the Blood Flow Measurement in a Micro-tube

Contact Info

Product

Resources

About