Specificity of Memory Deficits after Right or Left Temporal Lobectomy

Pillon, B.; Bazin, B.; Deweer, Bernard; Ehrlé, Nathalie; Baulac, Michel; Dubois, Bruno

doi:10.1016/s0010-9452(08)70819-0

Cited by 55 publications

(25 citation statements)

References 68 publications

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“…This interpretation is in agreement with reports showing less efficient encoding in elderly adults (Grady et al, 1995;Stebbins et al, 2002), was however not confirmed in a control study on a different group of subjects (Park et al, 1990). Interestingly, object location memory was shown to be dependent on the MTL region (Nunn et al, 1999;Pillon et al, 1999;Stepankova et al, 2004) or more specifically on the parahippocampal gyrus (Maguire et al, 1998b;Owen et al, 1996). Thus another interpretation of this age dependent object location memory deficit may attribute it to the decline in MTL activity.…”

Section: Spatial Memory and Navigationsupporting

confidence: 78%

Spatial Navigation Impairment in Healthy Aging and Alzheimer’s Disease

Vlček¹

2011

The Clinical Spectrum of Alzheimer's Disease -the Charge Toward Comprehensive Diagnostic and Therapeutic Strategies

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Section: Spatial Memory and Navigationsupporting

confidence: 78%

Spatial Navigation Impairment in Healthy Aging and Alzheimer’s Disease

Vlček¹

2011

The Clinical Spectrum of Alzheimer's Disease -the Charge Toward Comprehensive Diagnostic and Therapeutic Strategies

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“…The insula has several connections with the limbic system, most notably with the amygdala and also with the temporal lobe [42]. Connections with the temporal lobe are important with regard to memory processing functions [43,44]. Thus lesions to, or reductions in, insula volume may be associated with memory impairment.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Neurocognition and Regional Brain Volumes in Traumatized Adolescents with and without Posttraumatic Stress Disorder

Ahmed

Spottiswoode²,

Carey³

et al. 2012

Neuropsychobiology

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Objectives: Studies using convergent neurocognitive and structural imaging paradigms in adolescent posttraumatic stress disorder (PTSD) are limited; in the current study we used both voxel-based morphometry (VBM) to obtain between-group volumetric differences, and Freesurfer to examine the relationship between cognition and regional brain volumes. Methods: Participants were 21 traumatized adolescents with PTSD matched with 32 traumatized adolescents without PTSD. Magnetic resonance images were obtained on a 1.5-Tesla MAGNETOM Siemens Symphony scanner. VBM implemented on FSL was then used to compare between-group grey matter volumes, after which Freesurfer was used to obtain global volume and thickness measurements in different brain regions. Results: Significant between-group neurocognitive differences were found for tests of attention, delayed recall and visual reconstruction. On VBM, reduced grey matter was found in three regions in the PTSD group: left insula, right precuneus and right cingulate gyrus, using uncorrected values (p < 0.001), while no statistically significant between-group differences were found on the initial Freesurfer stream. Further Freesurfer analysis on Qdec revealed significant reductions in the insula for the PTSD group. In addition, volumetric changes in the corpus callosum and insula were significantly associated with deficits in logical memory and visual reproduction on Freesurfer analysis. Conclusions: Trauma exposure of itself may be sufficient to cause structural changes in adolescents regardless of PTSD development.

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“…The hypothesized deficit in recall of nonverbal compared with verbal stimuli following right amygdala damage was not supported by the results. Several studies have documented deficits in visuospatial processing and memory for complex visual scenes following right temporal lobectomy (Barr 1997;Glosser et al 1998;Pillon et al 1999). One possible mechanism that might account for the impaired verbal emotional memory in subjects with left amygdala damage, on the one hand, and yet the preserved nonverbal emotional memory in subjects with right amygdala damage, on the other hand, is the following.…”

Section: Buchanan Et Almentioning

confidence: 99%

Verbal and Nonverbal Emotional Memory Following Unilateral Amygdala Damage

Buchanan¹,

Denburg²,

Tranel³

et al. 2001

Learn. Mem.

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The amygdala is involved in the normal facilitation of memory by emotion, but the separate contributions of the left and right amygdala to memory for verbal or nonverbal emotional material have not been investigated. Fourteen patients with damage to the medial temporal lobe including the amygdala (seven left, seven right), 18 brain-damaged, and 36 normal controls were exposed to emotional and neutral pictures accompanied by verbal narratives. Memory for both narratives and pictures was assessed with a free recall test 24 h later. Subjects with left amygdala damage failed to show the normally robust enhancement of memory for verbal and nonverbal emotional stimuli. The group with right amygdala damage showed the normal pattern of facilitation of memory by emotion for both verbal and nonverbal stimuli despite an overall reduction in memory performance. Furthermore, subjects with left amygdala damage were disproportionately impaired on memory for emotional narratives as compared with memory for emotional pictures. The latter finding offers partial support for a lateralized and material-specific pattern of the amygdala's contribution to emotional memory.

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Specificity of Memory Deficits after Right or Left Temporal Lobectomy

Cited by 55 publications

References 68 publications

Spatial Navigation Impairment in Healthy Aging and Alzheimer’s Disease

Spatial Navigation Impairment in Healthy Aging and Alzheimer’s Disease

Relationship between Neurocognition and Regional Brain Volumes in Traumatized Adolescents with and without Posttraumatic Stress Disorder

Verbal and Nonverbal Emotional Memory Following Unilateral Amygdala Damage

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