Specificity of Familial Transmission of Schizophrenia Psychosis Spectrum and Affective Psychoses in the New England Family Study’s High-Risk Design

Goldstein, Jill M.; Buka, Stephen L.; Seidman, Larry J.; Tsuang, Ming T.

doi:10.1001/archgenpsychiatry.2010.38

Cited by 60 publications

(73 citation statements)

References 77 publications

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“…Inconsistent results have been reported regarding the question whether the predictive value of parental psychopathology for psychopathology in the offspring is disorder specific (Goldstein, Buka, Seidman, & Tsuang, 2010;van Meurs et al, 2009), (internalising/externalising) spectrum specific (Kessler, Davis, & Kendler, 1997) or more diffuse (Bijl, Cuijpers, & Smit, 2002;Keshavan et al, 2008). The present results suggest that general parental psychopathology is associated with a broader spectrum of mild psychotic symptomatology, as represented by the measurement of (cross sectional) experiences at age 15 16 years, capturing both potentially transitory and persistent phenomena.…”

Section: Discussioncontrasting

confidence: 41%

14:15 Persistence of the Extended Psychosis Phenotype in Young People: Link Between Vulnerability and Clinical Need

Wigman¹,

Vollebergh²,

Yung³

et al. 2012

Schizophrenia Research

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Section: Discussioncontrasting

confidence: 41%

14:15 Persistence of the Extended Psychosis Phenotype in Young People: Link Between Vulnerability and Clinical Need

Wigman¹,

Vollebergh²,

Yung³

et al. 2012

Schizophrenia Research

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“…This result would suggest a certain heritability of ''psychotic'' clinical dimension and adds a new element in the actual debate about the opportunity to consider PMD as a diagnosis per se. In support of this hypothesis a recent study found that the offspring of schizophrenic patients had a doubling risk for ''Affective Psychosis'' respect to controls (Goldstein et al, 2010). In addition a genetic study found that the allele A of the gene of dopamine bhydroxylase was associated with delusional ideation in a sample of major depressives, confirming the genetic predisposition to develop psychotic symptoms (Wood et al, 2002).…”

Section: Discussionmentioning

confidence: 89%

Psychotic versus non-psychotic major depressive disorder: A comparative naturalistic study

Buoli

Caldiroli

Altamura

2013

Asian Journal of Psychiatry

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“…We would speculate that this risk is increased as high risk individuals who later convert to psychosis have more severe neuropsychological impairment than non-converters and converters with a positive family history of psychosis have the most severe neuropsychological impairment prior to onset of psychosis . Other publications with this NEFS high-risk project have reported on rates of psychotic disorders in adulthood [Goldstein et al, 2010[Goldstein et al, , 2011. Consistent with previous high-risk samples, approximately 12% of the high-risk offspring met lifetime Family SES: socioeconomic-index, measured as a composite index of family income, education, and occupation according to the system used by the United States Bureau of the Census, ranging from 0.0 ("lowest") to 9.5 ("highest").…”

Section: Discussionmentioning

confidence: 99%

The New England family study high‐risk project: Neurological impairments among offspring of parents with schizophrenia and other psychoses

Buka

Seidman

Tsuang

et al. 2013

American J of Med Genetics Pt B

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This manuscript presents the design and initial outcomes of the New England Family Study's (NEFS) High-Risk Project, one of the few epidemiologically representative cohorts that has prospectively followed a large sample of offspring of parents with both affective and non-affective psychotic disorders from the fetal period forward. The goals of this report are: (1) to describe in some detail the design, data collection methods, and resulting sample of this project; and (2) to prospectively identify and compare rates of childhood neurological impairments among offspring of psychotic and nonpsychotic parents, with a particular emphasis on offspring risk in relation to specific classes of parental psychosis (i.e., affective vs. non-affective psychosis). The investigators identified a pool of 755 parents with potential psychotic disorders, located over 80% of these and confirmed psychotic diagnoses for 212 affected parents and 132 unaffected control parents. At birth, the 259 offspring of parents with psychosis had approximately a twofold increased risk of abnormal neurological functioning compared to offspring of families with no psychotic history. This was most pronounced among the 58 offspring of parents with schizophrenia. Similar trends were observed at ages 1 and 7 years although these did not reach statistical significance. Neither at birth nor at any of the follow-up assessments were the 157 offspring of parents with affective psychosis found to be at elevated risk of neurological impairment. Implications for future research and potential preventive interventions for at-risk individuals are discussed. INTRODUCTIONHigh-risk (HR) studies have proven invaluable over the past 50 years to advance understanding of the biological and social origins and course of schizophrenia and other psychotic disorders [Niemi et al., 2003;Cunningham Owens and Johnstone, 2006]. Alternative designs, such as cohort and conscript studies, are difficult to carry out due to the relatively low incidence of psychotic disorders in the general population, necessitating a large sample of individuals at general risk. An associated challenge is that with such large samples it is difficult and expensive to collect rich and detailed premorbid assessments prior to the onset of later psychotic disorders. In contrast, HR studies-in which a disorder or a condition is studied by selecting individuals at established elevated risk for the disorder [Cornblatt and Obuchowski, 1997]-require smaller sample sizes and allow a wider range of methods to be employed because of reduced expense in sampling. Specifically, the ability to identify individuals at a very early age (sometimes at or even before 653Neuropsychiatric Genetics birth) who are at elevated risk of developing schizophrenia later in life owing to an ill family member, usually parents or siblings, ("family HR" or "genetic HR" design) has supplemented the work from cohort studies, and has permitted focused and detailed assessments of premorbid conditions.Prior family high-risk (FHR) studies hav...

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Specificity of Familial Transmission of Schizophrenia Psychosis Spectrum and Affective Psychoses in the New England Family Study’s High-Risk Design

Cited by 60 publications

References 77 publications

14:15 Persistence of the Extended Psychosis Phenotype in Young People: Link Between Vulnerability and Clinical Need

14:15 Persistence of the Extended Psychosis Phenotype in Young People: Link Between Vulnerability and Clinical Need

Psychotic versus non-psychotic major depressive disorder: A comparative naturalistic study

The New England family study high‐risk project: Neurological impairments among offspring of parents with schizophrenia and other psychoses

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